Anti-inflammatory activities of furanoditerpenoids and other constituents from Fibraurea tinctoria

Chung Ren Su; Yuh Fung Chen; Meei Jen Liou; Huei Yann Tsai; Wen Shin Chang; Tian Shung Wu

doi:10.1016/j.bmc.2008.09.023

Anti-inflammatory activities of furanoditerpenoids and other constituents from Fibraurea tinctoria

Chung Ren Su, Yuh Fung Chen, Meei Jen Liou, Huei Yann Tsai, Wen Shin Chang, Tian Shung Wu

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Five new furanoditerpenoids, epi-8-hydroxycolumbin (1), fibaruretin B (2), C (3), E (5), and F (6), were isolated from the stems of Fibraurea tinctoria, as well as fibaruretin D (4) from the natural source for the first time, and 39 known compounds. The structures (1-6) were elucidated on the basis of spectroscopic analysis. All the isolated furanoditerpenoids (1-16) were examined for their in vitro activity and some were in vivo anti-inflammatory activity. Compounds 8 and 9 showed significant anti-inflammatory action administered at a dose of 100 mg/kg of reducing carrageenan mice paw edema, whereas compound 7, 9, 10, 14, and 16 were more potent to inhibit NO production. The inhibitory effects of these compounds are dose-dependent (1-4 μg/ml).

Original language	English
Pages (from-to)	9603-9609
Number of pages	7
Journal	Bioorganic and Medicinal Chemistry
Volume	16
Issue number	21
DOIs	https://doi.org/10.1016/j.bmc.2008.09.023
Publication status	Published - 2008 Nov 1

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/j.bmc.2008.09.023

Fingerprint Dive into the research topics of 'Anti-inflammatory activities of furanoditerpenoids and other constituents from Fibraurea tinctoria'. Together they form a unique fingerprint.

Cite this

@article{13ba76183c204f8d8701d8cdfa5bb73d,

title = "Anti-inflammatory activities of furanoditerpenoids and other constituents from Fibraurea tinctoria",

abstract = "Five new furanoditerpenoids, epi-8-hydroxycolumbin (1), fibaruretin B (2), C (3), E (5), and F (6), were isolated from the stems of Fibraurea tinctoria, as well as fibaruretin D (4) from the natural source for the first time, and 39 known compounds. The structures (1-6) were elucidated on the basis of spectroscopic analysis. All the isolated furanoditerpenoids (1-16) were examined for their in vitro activity and some were in vivo anti-inflammatory activity. Compounds 8 and 9 showed significant anti-inflammatory action administered at a dose of 100 mg/kg of reducing carrageenan mice paw edema, whereas compound 7, 9, 10, 14, and 16 were more potent to inhibit NO production. The inhibitory effects of these compounds are dose-dependent (1-4 μg/ml).",

author = "Su, {Chung Ren} and Chen, {Yuh Fung} and Liou, {Meei Jen} and Tsai, {Huei Yann} and Chang, {Wen Shin} and Wu, {Tian Shung}",

year = "2008",

month = nov,

day = "1",

doi = "10.1016/j.bmc.2008.09.023",

language = "English",

volume = "16",

pages = "9603--9609",

journal = "Bioorganic and Medicinal Chemistry",

issn = "0968-0896",

publisher = "Elsevier Limited",

number = "21",

}

TY - JOUR

T1 - Anti-inflammatory activities of furanoditerpenoids and other constituents from Fibraurea tinctoria

AU - Su, Chung Ren

AU - Chen, Yuh Fung

AU - Liou, Meei Jen

AU - Tsai, Huei Yann

AU - Chang, Wen Shin

AU - Wu, Tian Shung

PY - 2008/11/1

Y1 - 2008/11/1

N2 - Five new furanoditerpenoids, epi-8-hydroxycolumbin (1), fibaruretin B (2), C (3), E (5), and F (6), were isolated from the stems of Fibraurea tinctoria, as well as fibaruretin D (4) from the natural source for the first time, and 39 known compounds. The structures (1-6) were elucidated on the basis of spectroscopic analysis. All the isolated furanoditerpenoids (1-16) were examined for their in vitro activity and some were in vivo anti-inflammatory activity. Compounds 8 and 9 showed significant anti-inflammatory action administered at a dose of 100 mg/kg of reducing carrageenan mice paw edema, whereas compound 7, 9, 10, 14, and 16 were more potent to inhibit NO production. The inhibitory effects of these compounds are dose-dependent (1-4 μg/ml).

AB - Five new furanoditerpenoids, epi-8-hydroxycolumbin (1), fibaruretin B (2), C (3), E (5), and F (6), were isolated from the stems of Fibraurea tinctoria, as well as fibaruretin D (4) from the natural source for the first time, and 39 known compounds. The structures (1-6) were elucidated on the basis of spectroscopic analysis. All the isolated furanoditerpenoids (1-16) were examined for their in vitro activity and some were in vivo anti-inflammatory activity. Compounds 8 and 9 showed significant anti-inflammatory action administered at a dose of 100 mg/kg of reducing carrageenan mice paw edema, whereas compound 7, 9, 10, 14, and 16 were more potent to inhibit NO production. The inhibitory effects of these compounds are dose-dependent (1-4 μg/ml).

UR - http://www.scopus.com/inward/record.url?scp=53749089235&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=53749089235&partnerID=8YFLogxK

U2 - 10.1016/j.bmc.2008.09.023

DO - 10.1016/j.bmc.2008.09.023

M3 - Article

C2 - 18829331

AN - SCOPUS:53749089235

VL - 16

SP - 9603

EP - 9609

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

SN - 0968-0896

IS - 21

ER -