Anti-inflammatory activities of furanoditerpenoids and other constituents from Fibraurea tinctoria

Chung Ren Su, Yuh Fung Chen, Meei Jen Liou, Huei Yann Tsai, Wen Shin Chang, Tian Shung Wu

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Five new furanoditerpenoids, epi-8-hydroxycolumbin (1), fibaruretin B (2), C (3), E (5), and F (6), were isolated from the stems of Fibraurea tinctoria, as well as fibaruretin D (4) from the natural source for the first time, and 39 known compounds. The structures (1-6) were elucidated on the basis of spectroscopic analysis. All the isolated furanoditerpenoids (1-16) were examined for their in vitro activity and some were in vivo anti-inflammatory activity. Compounds 8 and 9 showed significant anti-inflammatory action administered at a dose of 100 mg/kg of reducing carrageenan mice paw edema, whereas compound 7, 9, 10, 14, and 16 were more potent to inhibit NO production. The inhibitory effects of these compounds are dose-dependent (1-4 μg/ml).

Original languageEnglish
Pages (from-to)9603-9609
Number of pages7
JournalBioorganic and Medicinal Chemistry
Volume16
Issue number21
DOIs
Publication statusPublished - 2008 Nov 1

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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