TY - JOUR
T1 - Anti-inflammatory activities of furanoditerpenoids and other constituents from Fibraurea tinctoria
AU - Su, Chung Ren
AU - Chen, Yuh Fung
AU - Liou, Meei Jen
AU - Tsai, Huei Yann
AU - Chang, Wen Shin
AU - Wu, Tian Shung
N1 - Funding Information:
The authors are grateful for financial support from the National Science Council, Taiwan, Republic of China (NSC 95-2113-M-006-003) awarded to T.S. Wu.
PY - 2008/11/1
Y1 - 2008/11/1
N2 - Five new furanoditerpenoids, epi-8-hydroxycolumbin (1), fibaruretin B (2), C (3), E (5), and F (6), were isolated from the stems of Fibraurea tinctoria, as well as fibaruretin D (4) from the natural source for the first time, and 39 known compounds. The structures (1-6) were elucidated on the basis of spectroscopic analysis. All the isolated furanoditerpenoids (1-16) were examined for their in vitro activity and some were in vivo anti-inflammatory activity. Compounds 8 and 9 showed significant anti-inflammatory action administered at a dose of 100 mg/kg of reducing carrageenan mice paw edema, whereas compound 7, 9, 10, 14, and 16 were more potent to inhibit NO production. The inhibitory effects of these compounds are dose-dependent (1-4 μg/ml).
AB - Five new furanoditerpenoids, epi-8-hydroxycolumbin (1), fibaruretin B (2), C (3), E (5), and F (6), were isolated from the stems of Fibraurea tinctoria, as well as fibaruretin D (4) from the natural source for the first time, and 39 known compounds. The structures (1-6) were elucidated on the basis of spectroscopic analysis. All the isolated furanoditerpenoids (1-16) were examined for their in vitro activity and some were in vivo anti-inflammatory activity. Compounds 8 and 9 showed significant anti-inflammatory action administered at a dose of 100 mg/kg of reducing carrageenan mice paw edema, whereas compound 7, 9, 10, 14, and 16 were more potent to inhibit NO production. The inhibitory effects of these compounds are dose-dependent (1-4 μg/ml).
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U2 - 10.1016/j.bmc.2008.09.023
DO - 10.1016/j.bmc.2008.09.023
M3 - Article
C2 - 18829331
AN - SCOPUS:53749089235
VL - 16
SP - 9603
EP - 9609
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
SN - 0968-0896
IS - 21
ER -