Anti-inflammatory and neuroprotective constituents from the peels of citrus grandis

Ping Chung Kuo, Yu Ren Liao, Hsin Yi Hung, Chia Wei Chuang, Tsong Long Hwang, Shiow Chyn Huang, Young Ji Shiao, Daih Huang Kuo, Tian Shung Wu

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A series of chromatographic separations performed on the ethanol extracts of the peels of Citrus grandis has led to the characterization of forty compounds, including seventeen coumarins, eight flavonoids, two triterpenoids, four benzenoids, two steroids, one lignan, one amide, and five other compounds, respectively. The chemical structures of the purified constituents were identified on the basis of spectroscopic elucidation, including 1D- and 2D-NMR, UV, IR, and mass spectrometric analysis. Most of the isolated compounds were examined for their inhibition of superoxide anion generation and elastase release by human neutrophils. Among the isolates, isomeranzin (3), 17,18-dihydroxybergamottin (12), epoxybergamottin (13), rhoifolin (19), vitexicarpin (22) and 4-hydroxybenzaldehyde (29) displayed the most significant inhibition of superoxide anion generation and elastase release with IC50 values ranged from 0.54 to 7.57 µM, and 0.43 to 4.33 µM, respectively. In addition, 7-hydroxy-8-(2-hydroxy-3-methylbut-3-enyl)coumarin (8) and 17,18-dihydroxybergamottin (12) also exhibited the protection of neurons against Aβ-mediated neurotoxicity at 50 µM.

Original languageEnglish
Article number967
JournalMolecules
Volume22
Issue number6
DOIs
Publication statusPublished - 2017 Jun

Fingerprint

Citrus
inorganic peroxides
Pancreatic Elastase
Superoxides
Anti-Inflammatory Agents
neutrophils
anions
Coumarins
Lignans
steroids
neurons
Flavonoids
Amides
amides
Inhibitory Concentration 50
Neurons
Neutrophils
ethyl alcohol
Ethanol
Steroids

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Kuo, Ping Chung ; Liao, Yu Ren ; Hung, Hsin Yi ; Chuang, Chia Wei ; Hwang, Tsong Long ; Huang, Shiow Chyn ; Shiao, Young Ji ; Kuo, Daih Huang ; Wu, Tian Shung. / Anti-inflammatory and neuroprotective constituents from the peels of citrus grandis. In: Molecules. 2017 ; Vol. 22, No. 6.
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Kuo, PC, Liao, YR, Hung, HY, Chuang, CW, Hwang, TL, Huang, SC, Shiao, YJ, Kuo, DH & Wu, TS 2017, 'Anti-inflammatory and neuroprotective constituents from the peels of citrus grandis', Molecules, vol. 22, no. 6, 967. https://doi.org/10.3390/molecules22060967

Anti-inflammatory and neuroprotective constituents from the peels of citrus grandis. / Kuo, Ping Chung; Liao, Yu Ren; Hung, Hsin Yi; Chuang, Chia Wei; Hwang, Tsong Long; Huang, Shiow Chyn; Shiao, Young Ji; Kuo, Daih Huang; Wu, Tian Shung.

In: Molecules, Vol. 22, No. 6, 967, 06.2017.

Research output: Contribution to journalArticle

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