TY - JOUR
T1 - Anti-inflammatory, anticholinesterase and antioxidative constituents from the roots and the leaves of Salvia nipponica Miq. var. formosana
AU - Chan, Hsiu Hui
AU - Hwang, Tsong Long
AU - Su, Chung Ren
AU - Reddy, Mopur Vijaya Bhaskar
AU - Wu, Tian Shung
N1 - Funding Information:
The authors are grateful for financial support from the National Science Council of Republic of China awarded to T.-S. Wu. This study was supported in part by Taiwan Department of Health Cancer Research Center of Excellence (DOH99-TD-C-111-005).
PY - 2011/1/15
Y1 - 2011/1/15
N2 - Reactive oxygen species and granule proteases produced by neutrophils contribute to the pathogenesis of inflammatory diseases. The extracts of the roots and the leaves of Salvia nipponica var. formosana were showed potent inhibitory effects on superoxide anion production in fMLP/CB-activated human neutrophils as well as other anti-inflammatory effects, and led to the isolation of 25 compounds. Among them, compounds 8, 12, 13, 14, 15, 17 and 20 were exhibited more potent inhibitory effect on superoxide anion generation and elastase release by human neutrophils in response to fMLP/CB. Moreover, those isolated compounds also showed significant anticholinesterase and antioxidative activities. To the best of our knowledge, this is the first report of phytochemical and biological activity study on S. nipponica var. formosana. Crown
AB - Reactive oxygen species and granule proteases produced by neutrophils contribute to the pathogenesis of inflammatory diseases. The extracts of the roots and the leaves of Salvia nipponica var. formosana were showed potent inhibitory effects on superoxide anion production in fMLP/CB-activated human neutrophils as well as other anti-inflammatory effects, and led to the isolation of 25 compounds. Among them, compounds 8, 12, 13, 14, 15, 17 and 20 were exhibited more potent inhibitory effect on superoxide anion generation and elastase release by human neutrophils in response to fMLP/CB. Moreover, those isolated compounds also showed significant anticholinesterase and antioxidative activities. To the best of our knowledge, this is the first report of phytochemical and biological activity study on S. nipponica var. formosana. Crown
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U2 - 10.1016/j.phymed.2010.06.017
DO - 10.1016/j.phymed.2010.06.017
M3 - Article
C2 - 21115331
AN - SCOPUS:78651269781
SN - 0944-7113
VL - 18
SP - 148
EP - 150
JO - Phytomedicine
JF - Phytomedicine
IS - 2-3
ER -