Anti-inflammatory, anticholinesterase and antioxidative constituents from the roots and the leaves of Salvia nipponica Miq. var. formosana

Hsiu Hui Chan, Tsong Long Hwang, Chung Ren Su, Mopur Vijaya Bhaskar Reddy, Tian Shung Wu

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Reactive oxygen species and granule proteases produced by neutrophils contribute to the pathogenesis of inflammatory diseases. The extracts of the roots and the leaves of Salvia nipponica var. formosana were showed potent inhibitory effects on superoxide anion production in fMLP/CB-activated human neutrophils as well as other anti-inflammatory effects, and led to the isolation of 25 compounds. Among them, compounds 8, 12, 13, 14, 15, 17 and 20 were exhibited more potent inhibitory effect on superoxide anion generation and elastase release by human neutrophils in response to fMLP/CB. Moreover, those isolated compounds also showed significant anticholinesterase and antioxidative activities. To the best of our knowledge, this is the first report of phytochemical and biological activity study on S. nipponica var. formosana. Crown

Original languageEnglish
Pages (from-to)148-150
Number of pages3
JournalPhytomedicine
Volume18
Issue number2-3
DOIs
Publication statusPublished - 2011 Jan 15

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

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