Anti-inflammatory diterpenoids from croton tonkinensis

Ping Chung Kuo; Mei Lin Yang; Tsong Long Hwang; Yuan Yu Lai; Yue Chiun Li; Tran Dinh Thang; Tian Shung Wu

doi:10.1021/np300699f

Anti-inflammatory diterpenoids from croton tonkinensis

Ping Chung Kuo, Mei Lin Yang, Tsong Long Hwang, Yuan Yu Lai, Yue Chiun Li, Tran Dinh Thang, Tian Shung Wu

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Phytochemical investigation of the methanolic extract of Croton tonkinensis afforded two known kauranes (1, 2), eight new ent-kauranes (3-10), and 16 known ent-kauranetype diterpenoids (12-27). In addition, 30 known compounds were identified by comparison of their physical and spectroscopic data with reported data. Among the isolated compounds, ent-18-acetoxykaur-16-en-15-one (20) displayed the most significant inhibition of superoxide anion generation and elastase release.

Original language	English
Pages (from-to)	230-236
Number of pages	7
Journal	Journal of Natural Products
Volume	76
Issue number	2
DOIs	https://doi.org/10.1021/np300699f
Publication status	Published - 2013 Feb 22

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "Anti-inflammatory diterpenoids from croton tonkinensis",

abstract = "Phytochemical investigation of the methanolic extract of Croton tonkinensis afforded two known kauranes (1, 2), eight new ent-kauranes (3-10), and 16 known ent-kauranetype diterpenoids (12-27). In addition, 30 known compounds were identified by comparison of their physical and spectroscopic data with reported data. Among the isolated compounds, ent-18-acetoxykaur-16-en-15-one (20) displayed the most significant inhibition of superoxide anion generation and elastase release.",

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T1 - Anti-inflammatory diterpenoids from croton tonkinensis

AU - Kuo, Ping Chung

AU - Yang, Mei Lin

AU - Hwang, Tsong Long

AU - Lai, Yuan Yu

AU - Li, Yue Chiun

AU - Thang, Tran Dinh

AU - Wu, Tian Shung

PY - 2013/2/22

Y1 - 2013/2/22

N2 - Phytochemical investigation of the methanolic extract of Croton tonkinensis afforded two known kauranes (1, 2), eight new ent-kauranes (3-10), and 16 known ent-kauranetype diterpenoids (12-27). In addition, 30 known compounds were identified by comparison of their physical and spectroscopic data with reported data. Among the isolated compounds, ent-18-acetoxykaur-16-en-15-one (20) displayed the most significant inhibition of superoxide anion generation and elastase release.

AB - Phytochemical investigation of the methanolic extract of Croton tonkinensis afforded two known kauranes (1, 2), eight new ent-kauranes (3-10), and 16 known ent-kauranetype diterpenoids (12-27). In addition, 30 known compounds were identified by comparison of their physical and spectroscopic data with reported data. Among the isolated compounds, ent-18-acetoxykaur-16-en-15-one (20) displayed the most significant inhibition of superoxide anion generation and elastase release.

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