Anti-inflammatory Flavan-3-ol-dihydroretrochalcones from Daemonorops draco

Ping Chung Kuo; Hsin Yi Hung; Tsong Long Hwang; Wen Ke Du; Hsiang Chih Ku; E. Jian Lee; Shih Huang Tai; Fu An Chen; Tian Shung Wu

doi:10.1021/acs.jnatprod.7b00039

Anti-inflammatory Flavan-3-ol-dihydroretrochalcones from Daemonorops draco

Ping Chung Kuo, Hsin Yi Hung, Tsong Long Hwang, Wen Ke Du, Hsiang Chih Ku, E. Jian Lee, Shih Huang Tai, Fu An Chen, Tian Shung Wu

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Four A-type flavan-3-ol-dihydroretrochalcone dimers, dragonins A-D (1-4), were characterized from the traditional Chinese medicine Sanguis Draconis. The structures of 1-4 were elucidated by spectroscopic and spectrometric analyses. Compounds 1 and 2 exhibited significant inhibition of fMLP/CB-induced superoxide anion and elastase. The signaling pathways accounting for the inhibitory effects of compound 2 were also elucidated. These purified A-type flavan-3-ol-dihydroretrochalcones are new potential leads for the development of anti-inflammatory drugs.

Original language	English
Pages (from-to)	783-789
Number of pages	7
Journal	Journal of Natural Products
Volume	80
Issue number	4
DOIs	https://doi.org/10.1021/acs.jnatprod.7b00039
Publication status	Published - 2017 Apr 28

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/acs.jnatprod.7b00039

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title = "Anti-inflammatory Flavan-3-ol-dihydroretrochalcones from Daemonorops draco",

abstract = "Four A-type flavan-3-ol-dihydroretrochalcone dimers, dragonins A-D (1-4), were characterized from the traditional Chinese medicine Sanguis Draconis. The structures of 1-4 were elucidated by spectroscopic and spectrometric analyses. Compounds 1 and 2 exhibited significant inhibition of fMLP/CB-induced superoxide anion and elastase. The signaling pathways accounting for the inhibitory effects of compound 2 were also elucidated. These purified A-type flavan-3-ol-dihydroretrochalcones are new potential leads for the development of anti-inflammatory drugs.",

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doi = "10.1021/acs.jnatprod.7b00039",

language = "English",

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T1 - Anti-inflammatory Flavan-3-ol-dihydroretrochalcones from Daemonorops draco

AU - Kuo, Ping Chung

AU - Hung, Hsin Yi

AU - Hwang, Tsong Long

AU - Du, Wen Ke

AU - Ku, Hsiang Chih

AU - Lee, E. Jian

AU - Tai, Shih Huang

AU - Chen, Fu An

AU - Wu, Tian Shung

PY - 2017/4/28

Y1 - 2017/4/28

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AB - Four A-type flavan-3-ol-dihydroretrochalcone dimers, dragonins A-D (1-4), were characterized from the traditional Chinese medicine Sanguis Draconis. The structures of 1-4 were elucidated by spectroscopic and spectrometric analyses. Compounds 1 and 2 exhibited significant inhibition of fMLP/CB-induced superoxide anion and elastase. The signaling pathways accounting for the inhibitory effects of compound 2 were also elucidated. These purified A-type flavan-3-ol-dihydroretrochalcones are new potential leads for the development of anti-inflammatory drugs.

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Anti-inflammatory Flavan-3-ol-dihydroretrochalcones from Daemonorops draco

Abstract

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