Anti-inflammatory Flavan-3-ol-dihydroretrochalcones from Daemonorops draco

Ping Chung Kuo, Hsin Yi Hung, Tsong Long Hwang, Wen Ke Du, Hsiang Chih Ku, E. Jian Lee, Shih Huang Tai, Fu An Chen, Tian Shung Wu

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Four A-type flavan-3-ol-dihydroretrochalcone dimers, dragonins A-D (1-4), were characterized from the traditional Chinese medicine Sanguis Draconis. The structures of 1-4 were elucidated by spectroscopic and spectrometric analyses. Compounds 1 and 2 exhibited significant inhibition of fMLP/CB-induced superoxide anion and elastase. The signaling pathways accounting for the inhibitory effects of compound 2 were also elucidated. These purified A-type flavan-3-ol-dihydroretrochalcones are new potential leads for the development of anti-inflammatory drugs.

Original languageEnglish
Pages (from-to)783-789
Number of pages7
JournalJournal of Natural Products
Volume80
Issue number4
DOIs
Publication statusPublished - 2017 Apr 28

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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