Anti-inflammatory Flavan-3-ol-dihydroretrochalcones from Daemonorops draco

Ping-Chung Kuo, Hsin-Yi Hung, Tsong Long Hwang, Wen Ke Du, Hsiang Chih Ku, E-Jian Lee, Shih-Huang Tai, Fu An Chen, Tian-Shung Wu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Four A-type flavan-3-ol-dihydroretrochalcone dimers, dragonins A-D (1-4), were characterized from the traditional Chinese medicine Sanguis Draconis. The structures of 1-4 were elucidated by spectroscopic and spectrometric analyses. Compounds 1 and 2 exhibited significant inhibition of fMLP/CB-induced superoxide anion and elastase. The signaling pathways accounting for the inhibitory effects of compound 2 were also elucidated. These purified A-type flavan-3-ol-dihydroretrochalcones are new potential leads for the development of anti-inflammatory drugs.

Original languageEnglish
Pages (from-to)783-789
Number of pages7
JournalJournal of Natural Products
Volume80
Issue number4
DOIs
Publication statusPublished - 2017 Apr 28

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Anti-Inflammatory Agents
Pancreatic Elastase
Chinese Traditional Medicine
Superoxides
Dimers
Medicine
Pharmaceutical Preparations
flavan-3-ol

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Kuo, Ping-Chung ; Hung, Hsin-Yi ; Hwang, Tsong Long ; Du, Wen Ke ; Ku, Hsiang Chih ; Lee, E-Jian ; Tai, Shih-Huang ; Chen, Fu An ; Wu, Tian-Shung. / Anti-inflammatory Flavan-3-ol-dihydroretrochalcones from Daemonorops draco. In: Journal of Natural Products. 2017 ; Vol. 80, No. 4. pp. 783-789.
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Anti-inflammatory Flavan-3-ol-dihydroretrochalcones from Daemonorops draco. / Kuo, Ping-Chung; Hung, Hsin-Yi; Hwang, Tsong Long; Du, Wen Ke; Ku, Hsiang Chih; Lee, E-Jian; Tai, Shih-Huang; Chen, Fu An; Wu, Tian-Shung.

In: Journal of Natural Products, Vol. 80, No. 4, 28.04.2017, p. 783-789.

Research output: Contribution to journalArticle

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AU - Du, Wen Ke

AU - Ku, Hsiang Chih

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