Abstract
Nine neolignan derivatives (1-9) were characterized from the roots of Magnolia officinalis, and their structures were elucidated based on spectroscopic and physicochemical analyses. Among them, houpulins E (1) and M (9) possess novel homo- and trinor-neolignan skeletons. In addition, 15 known compounds (10-24) were identified by comparison of their spectroscopic and physical data with those reported in the literature. Some of the purified constituents were examined for anti-inflammatory activity and, among the tested compounds, houpulins G (3), I (5), J (6), and 2,2'-dihydroxy-3-methoxy-5,5'-di-(2-propenylbiphenyl) (19) significantly inhibited superoxide anion generation and elastase release with IC50 values ranging from 3.54 to 5.48 μM and 2.16 to 3.39 μM, respectively. Therefore, these neolignan derivatives have tremendous potential to be explored as anti-inflammatory agents.
| Original language | English |
|---|---|
| Pages (from-to) | 1439-1445 |
| Number of pages | 7 |
| Journal | Bioorganic and Medicinal Chemistry |
| Volume | 24 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2016 Apr 1 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry
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Anti-inflammatory neolignans from the roots of Magnolia officinalis. / Shih, Hung Cheng; Kuo, Ping Chung; Wu, Shwu Jen; Hwang, Tsong Long; Hung, Hsin Yi; Shen, De Yang; Shieh, Po Chuen; Liao, Yu Ren; Lee, E. Jian; Gu, Qiong; Lee, Kuo Hsiung; Wu, Tian Shung.
In: Bioorganic and Medicinal Chemistry, Vol. 24, No. 7, 01.04.2016, p. 1439-1445.Research output: Contribution to journal › Article
TY - JOUR
T1 - Anti-inflammatory neolignans from the roots of Magnolia officinalis
AU - Shih, Hung Cheng
AU - Kuo, Ping Chung
AU - Wu, Shwu Jen
AU - Hwang, Tsong Long
AU - Hung, Hsin Yi
AU - Shen, De Yang
AU - Shieh, Po Chuen
AU - Liao, Yu Ren
AU - Lee, E. Jian
AU - Gu, Qiong
AU - Lee, Kuo Hsiung
AU - Wu, Tian Shung
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Nine neolignan derivatives (1-9) were characterized from the roots of Magnolia officinalis, and their structures were elucidated based on spectroscopic and physicochemical analyses. Among them, houpulins E (1) and M (9) possess novel homo- and trinor-neolignan skeletons. In addition, 15 known compounds (10-24) were identified by comparison of their spectroscopic and physical data with those reported in the literature. Some of the purified constituents were examined for anti-inflammatory activity and, among the tested compounds, houpulins G (3), I (5), J (6), and 2,2'-dihydroxy-3-methoxy-5,5'-di-(2-propenylbiphenyl) (19) significantly inhibited superoxide anion generation and elastase release with IC50 values ranging from 3.54 to 5.48 μM and 2.16 to 3.39 μM, respectively. Therefore, these neolignan derivatives have tremendous potential to be explored as anti-inflammatory agents.
AB - Nine neolignan derivatives (1-9) were characterized from the roots of Magnolia officinalis, and their structures were elucidated based on spectroscopic and physicochemical analyses. Among them, houpulins E (1) and M (9) possess novel homo- and trinor-neolignan skeletons. In addition, 15 known compounds (10-24) were identified by comparison of their spectroscopic and physical data with those reported in the literature. Some of the purified constituents were examined for anti-inflammatory activity and, among the tested compounds, houpulins G (3), I (5), J (6), and 2,2'-dihydroxy-3-methoxy-5,5'-di-(2-propenylbiphenyl) (19) significantly inhibited superoxide anion generation and elastase release with IC50 values ranging from 3.54 to 5.48 μM and 2.16 to 3.39 μM, respectively. Therefore, these neolignan derivatives have tremendous potential to be explored as anti-inflammatory agents.
UR - http://www.scopus.com/inward/record.url?scp=84960303383&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84960303383&partnerID=8YFLogxK
U2 - 10.1016/j.bmc.2016.01.049
DO - 10.1016/j.bmc.2016.01.049
M3 - Article
C2 - 26928286
AN - SCOPUS:84960303383
VL - 24
SP - 1439
EP - 1445
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
SN - 0968-0896
IS - 7
ER -