Anti-inflammatory principles from Cordyceps sinensis

Mei Lin Yang; Ping Chung Kuo; Tsong Long Hwang; Tian Shung Wu

doi:10.1021/np100902f

Anti-inflammatory principles from Cordyceps sinensis

Mei Lin Yang, Ping Chung Kuo, Tsong Long Hwang, Tian Shung Wu

Research output: Contribution to journal › Article › peer-review

90 Citations (Scopus)

Abstract

In order to explore the anti-inflammatory principles of the mycelia of Cordyceps sinensis, the crude extract and partially purified fractions were examined for their inhibition of superoxide anion generation and elastase release. Further chemical investigation of the bioactive fractions has resulted in the identification of 50 compounds, including five constituents, cordysinins A-E (1-5), reported from a natural source for the first time. In addition, compounds were examined for their anti-inflammatory activity. 1-(5-Hydroxymethyl-2-furyl)-β-carboline displayed the most significant inhibition of superoxide anion generation and elastase release with IC ₅₀ values of 0.45 ± 0.15 and 1.68 ± 0.32 μM, respectively.

Original language	English
Pages (from-to)	1996-2000
Number of pages	5
Journal	Journal of Natural Products
Volume	74
Issue number	9
DOIs	https://doi.org/10.1021/np100902f
Publication status	Published - 2011 Sept 23

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np100902f

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AB - In order to explore the anti-inflammatory principles of the mycelia of Cordyceps sinensis, the crude extract and partially purified fractions were examined for their inhibition of superoxide anion generation and elastase release. Further chemical investigation of the bioactive fractions has resulted in the identification of 50 compounds, including five constituents, cordysinins A-E (1-5), reported from a natural source for the first time. In addition, compounds were examined for their anti-inflammatory activity. 1-(5-Hydroxymethyl-2-furyl)-β-carboline displayed the most significant inhibition of superoxide anion generation and elastase release with IC 50 values of 0.45 ± 0.15 and 1.68 ± 0.32 μM, respectively.

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Anti-inflammatory principles from Cordyceps sinensis

Abstract

All Science Journal Classification (ASJC) codes

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