Anti-inflammatory principles from Cordyceps sinensis

Mei Lin Yang, Ping Chung Kuo, Tsong Long Hwang, Tian-Shung Wu

Research output: Contribution to journalArticlepeer-review

62 Citations (Scopus)

Abstract

In order to explore the anti-inflammatory principles of the mycelia of Cordyceps sinensis, the crude extract and partially purified fractions were examined for their inhibition of superoxide anion generation and elastase release. Further chemical investigation of the bioactive fractions has resulted in the identification of 50 compounds, including five constituents, cordysinins A-E (1-5), reported from a natural source for the first time. In addition, compounds were examined for their anti-inflammatory activity. 1-(5-Hydroxymethyl-2-furyl)-β-carboline displayed the most significant inhibition of superoxide anion generation and elastase release with IC 50 values of 0.45 ± 0.15 and 1.68 ± 0.32 μM, respectively.

Original languageEnglish
Pages (from-to)1996-2000
Number of pages5
JournalJournal of Natural Products
Volume74
Issue number9
DOIs
Publication statusPublished - 2011 Sep 23

All Science Journal Classification (ASJC) codes

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

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