Anti-inflammatory principles from Lindera aggregata

Ping Chung Kuo, Yi Hung Wu, Hsin Yi Hung, Sio Hong Lam, Guo Hao Ma, Liang Mou Kuo, Tsong Long Hwang, Daih Huang Kuo, Tian Shung Wu

Research output: Contribution to journalArticle

Abstract

Four new sesquiterpenes (1–4), one new alkaloid (5), and one new benzenoid glycoside (6) were characterized from Lindera aggregata, and their structures were elucidated according to their spectrometric analytical data. Among these isolates, 3 and 4 were constructed as possessing unprecedented carbon skeletons from the natural source. Some of these purified constituents were examined for their anti-inflammatory bioactivity. Among the tested compounds, linderaggredin C (3), (+)-N-methyllaurotetanine, and (+)-isoboldine displayed the significant inhibition of superoxide anion generation in human neutrophils with IC50 values of 7.45 ± 0.74, 8.36 ± 0.11, and 5.81 ± 0.59 μM, respectively.

Original languageEnglish
Article number127224
JournalBioorganic and Medicinal Chemistry Letters
Volume30
Issue number13
DOIs
Publication statusPublished - 2020 Jul 1

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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