Anti-inflammatory principles from Lindera aggregata

Ping Chung Kuo; Yi Hung Wu; Hsin Yi Hung; Sio Hong Lam; Guo Hao Ma; Liang Mou Kuo; Tsong Long Hwang; Daih Huang Kuo; Tian Shung Wu

doi:10.1016/j.bmcl.2020.127224

Anti-inflammatory principles from Lindera aggregata

Ping Chung Kuo, Yi Hung Wu, Hsin Yi Hung, Sio Hong Lam, Guo Hao Ma, Liang Mou Kuo, Tsong Long Hwang, Daih Huang Kuo, Tian Shung Wu

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11 Citations (Scopus)

Abstract

Four new sesquiterpenes (1–4), one new alkaloid (5), and one new benzenoid glycoside (6) were characterized from Lindera aggregata, and their structures were elucidated according to their spectrometric analytical data. Among these isolates, 3 and 4 were constructed as possessing unprecedented carbon skeletons from the natural source. Some of these purified constituents were examined for their anti-inflammatory bioactivity. Among the tested compounds, linderaggredin C (3), (+)-N-methyllaurotetanine, and (+)-isoboldine displayed the significant inhibition of superoxide anion generation in human neutrophils with IC₅₀ values of 7.45 ± 0.74, 8.36 ± 0.11, and 5.81 ± 0.59 μM, respectively.

Original language	English
Article number	127224
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	30
Issue number	13
DOIs	https://doi.org/10.1016/j.bmcl.2020.127224
Publication status	Published - 2020 Jul 1

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2020.127224

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title = "Anti-inflammatory principles from Lindera aggregata",

abstract = "Four new sesquiterpenes (1–4), one new alkaloid (5), and one new benzenoid glycoside (6) were characterized from Lindera aggregata, and their structures were elucidated according to their spectrometric analytical data. Among these isolates, 3 and 4 were constructed as possessing unprecedented carbon skeletons from the natural source. Some of these purified constituents were examined for their anti-inflammatory bioactivity. Among the tested compounds, linderaggredin C (3), (+)-N-methyllaurotetanine, and (+)-isoboldine displayed the significant inhibition of superoxide anion generation in human neutrophils with IC50 values of 7.45 ± 0.74, 8.36 ± 0.11, and 5.81 ± 0.59 μM, respectively.",

author = "Kuo, {Ping Chung} and Wu, {Yi Hung} and Hung, {Hsin Yi} and Lam, {Sio Hong} and Ma, {Guo Hao} and Kuo, {Liang Mou} and Hwang, {Tsong Long} and Kuo, {Daih Huang} and Wu, {Tian Shung}",

note = "Funding Information: This work was supported by grants from the Ministry of Science and Technology (MOST), Taiwan, awarded to P.-C.K. and T.-S.W. Funding Information: This work was supported by grants from the Ministry of Science and Technology (MOST), Taiwan, awarded to P.-C.K. and T.-S.W. Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2020",

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doi = "10.1016/j.bmcl.2020.127224",

language = "English",

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AU - Kuo, Ping Chung

AU - Wu, Yi Hung

AU - Hung, Hsin Yi

AU - Lam, Sio Hong

AU - Ma, Guo Hao

AU - Kuo, Liang Mou

AU - Hwang, Tsong Long

AU - Kuo, Daih Huang

AU - Wu, Tian Shung

N1 - Funding Information: This work was supported by grants from the Ministry of Science and Technology (MOST), Taiwan, awarded to P.-C.K. and T.-S.W. Funding Information: This work was supported by grants from the Ministry of Science and Technology (MOST), Taiwan, awarded to P.-C.K. and T.-S.W. Publisher Copyright: © 2020 Elsevier Ltd

PY - 2020/7/1

Y1 - 2020/7/1

N2 - Four new sesquiterpenes (1–4), one new alkaloid (5), and one new benzenoid glycoside (6) were characterized from Lindera aggregata, and their structures were elucidated according to their spectrometric analytical data. Among these isolates, 3 and 4 were constructed as possessing unprecedented carbon skeletons from the natural source. Some of these purified constituents were examined for their anti-inflammatory bioactivity. Among the tested compounds, linderaggredin C (3), (+)-N-methyllaurotetanine, and (+)-isoboldine displayed the significant inhibition of superoxide anion generation in human neutrophils with IC50 values of 7.45 ± 0.74, 8.36 ± 0.11, and 5.81 ± 0.59 μM, respectively.

AB - Four new sesquiterpenes (1–4), one new alkaloid (5), and one new benzenoid glycoside (6) were characterized from Lindera aggregata, and their structures were elucidated according to their spectrometric analytical data. Among these isolates, 3 and 4 were constructed as possessing unprecedented carbon skeletons from the natural source. Some of these purified constituents were examined for their anti-inflammatory bioactivity. Among the tested compounds, linderaggredin C (3), (+)-N-methyllaurotetanine, and (+)-isoboldine displayed the significant inhibition of superoxide anion generation in human neutrophils with IC50 values of 7.45 ± 0.74, 8.36 ± 0.11, and 5.81 ± 0.59 μM, respectively.

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Anti-inflammatory principles from Lindera aggregata

Abstract

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