Antiallergic potential on RBL-2H3 cells of some phenolic constituents of Zingiber officinale (ginger)

Bing Hung Chen; Pei Yu Wu; Kuan Ming Chen; Tzu Fun Fu; Hui Min Wang; Chung Yi Chen

doi:10.1021/np800555y

Antiallergic potential on RBL-2H3 cells of some phenolic constituents of Zingiber officinale (ginger)

Bing Hung Chen, Pei Yu Wu, Kuan Ming Chen, Tzu Fun Fu, Hui Min Wang, Chung Yi Chen

Department of Medical Laboratory Science and Biotechnology

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

In the present study on five pure phenolic compounds (1-5) isolated from the rhizomes of Zingiber officinale (ginger) and investigated for their antiallergic potency, rat basophilic leukemia (RBL-2H3) cells were incubated with these compounds and the release of β-hexosaminidase was measured kinetically. The data obtained suggest that ginger rhizomes harbor potent compounds capable of inhibiting allergic reactions and may be useful for the treatment and prevention of allergic diseases.

Original language	English
Pages (from-to)	950-953
Number of pages	4
Journal	Journal of Natural Products
Volume	72
Issue number	5
DOIs	https://doi.org/10.1021/np800555y
Publication status	Published - 2009 May 22

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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abstract = "In the present study on five pure phenolic compounds (1-5) isolated from the rhizomes of Zingiber officinale (ginger) and investigated for their antiallergic potency, rat basophilic leukemia (RBL-2H3) cells were incubated with these compounds and the release of β-hexosaminidase was measured kinetically. The data obtained suggest that ginger rhizomes harbor potent compounds capable of inhibiting allergic reactions and may be useful for the treatment and prevention of allergic diseases.",

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AU - Chen, Bing Hung

AU - Wu, Pei Yu

AU - Chen, Kuan Ming

AU - Fu, Tzu Fun

AU - Wang, Hui Min

AU - Chen, Chung Yi

PY - 2009/5/22

Y1 - 2009/5/22

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AB - In the present study on five pure phenolic compounds (1-5) isolated from the rhizomes of Zingiber officinale (ginger) and investigated for their antiallergic potency, rat basophilic leukemia (RBL-2H3) cells were incubated with these compounds and the release of β-hexosaminidase was measured kinetically. The data obtained suggest that ginger rhizomes harbor potent compounds capable of inhibiting allergic reactions and may be useful for the treatment and prevention of allergic diseases.

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