Anticholinergic properties of brompheniramine, chlorpheniramine, and atropine in human nasal mucosa in vitro

Sheen Yie Fang, Howard M. Druce, James N. Baraniuk

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Brompheniramine and chlorpheniramine have anticholinergic activities, but the relative potency of these effects has not been well defined. The anticholinergic properties of brompheniramine, chlorpheniramine, and atropine were assessed in an in vitro model of human nasal mucosal glandular secretion. Methacholine was used as a cholinergic agonist to stimulate glandular secretion of 7F10-mucin. These drugs (0.01-1000 μM) or vehicle (saline) were added to explant cultures with and without 100 μM methacholine. 7F10-mucin concentrations were measured in culture supernatants after 2-hour incubations. The effective dose reducing methacholine-induced secretion (ED50) was determined. ED50 was 0.25 μM for atropine, 4.10 μM for brompheniramine, and 4.63 μM for chlorpheniramine. None of the anticholinergic drugs changed spontaneous glandular exocytosis. Brompheniramine and chlorpheniramine are equipotent anticholinergic agents in human nasal mucosa in vitro. Atropine was 16 to 19 times more potent.

Original languageEnglish
Pages (from-to)131-133
Number of pages3
JournalAmerican Journal of Rhinology
Volume12
Issue number2
DOIs
Publication statusPublished - 1998 Jan 1

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

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