Antidepressant principles of the roots of polygala tenuifolia

Mo Chi Cheng; Chia Ying Li; Han Chieh Ko; Feng Nien Ko; Yun Lian Lin; Tian Shung Wu

doi:10.1021/np060207r

Antidepressant principles of the roots of polygala tenuifolia

Mo Chi Cheng, Chia Ying Li, Han Chieh Ko, Feng Nien Ko, Yun Lian Lin, Tian Shung Wu

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

[¹²⁵I]RTI-55-membrane binding assay-guided fractionation and separation of a water-soluble extract of the roots of Polygala tenuifolia gave five new oligosaccharide derivatives, polygalatenosides A-E (1-5). The structures of these new oligosaccharides were established on the basis of spectroscopic evidence. Polygalatenosides A and B (1 and 2) showed significant inhibitory activity, with IC₅₀ values of 30.0 and 6.04 μM, respectively, in this membrane binding assay and acted as norepinephrine reuptake inhibitors through blocking norepinephrine transport.

Original language	English
Pages (from-to)	1305-1309
Number of pages	5
Journal	Journal of Natural Products
Volume	69
Issue number	9
DOIs	https://doi.org/10.1021/np060207r
Publication status	Published - 2006 Sep 1

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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abstract = "[125I]RTI-55-membrane binding assay-guided fractionation and separation of a water-soluble extract of the roots of Polygala tenuifolia gave five new oligosaccharide derivatives, polygalatenosides A-E (1-5). The structures of these new oligosaccharides were established on the basis of spectroscopic evidence. Polygalatenosides A and B (1 and 2) showed significant inhibitory activity, with IC50 values of 30.0 and 6.04 μM, respectively, in this membrane binding assay and acted as norepinephrine reuptake inhibitors through blocking norepinephrine transport.",

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AU - Cheng, Mo Chi

AU - Li, Chia Ying

AU - Ko, Han Chieh

AU - Ko, Feng Nien

AU - Lin, Yun Lian

AU - Wu, Tian Shung

PY - 2006/9/1

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AB - [125I]RTI-55-membrane binding assay-guided fractionation and separation of a water-soluble extract of the roots of Polygala tenuifolia gave five new oligosaccharide derivatives, polygalatenosides A-E (1-5). The structures of these new oligosaccharides were established on the basis of spectroscopic evidence. Polygalatenosides A and B (1 and 2) showed significant inhibitory activity, with IC50 values of 30.0 and 6.04 μM, respectively, in this membrane binding assay and acted as norepinephrine reuptake inhibitors through blocking norepinephrine transport.

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Antidepressant principles of the roots of polygala tenuifolia

Abstract

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