Antidepressant principles of the roots of polygala tenuifolia

Mo Chi Cheng, Chia Ying Li, Han Chieh Ko, Feng Nien Ko, Yun Lian Lin, Tian Shung Wu

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Abstract

[125I]RTI-55-membrane binding assay-guided fractionation and separation of a water-soluble extract of the roots of Polygala tenuifolia gave five new oligosaccharide derivatives, polygalatenosides A-E (1-5). The structures of these new oligosaccharides were established on the basis of spectroscopic evidence. Polygalatenosides A and B (1 and 2) showed significant inhibitory activity, with IC50 values of 30.0 and 6.04 μM, respectively, in this membrane binding assay and acted as norepinephrine reuptake inhibitors through blocking norepinephrine transport.

Original languageEnglish
Pages (from-to)1305-1309
Number of pages5
JournalJournal of Natural Products
Volume69
Issue number9
DOIs
Publication statusPublished - 2006 Sep 1

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All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Cheng, M. C., Li, C. Y., Ko, H. C., Ko, F. N., Lin, Y. L., & Wu, T. S. (2006). Antidepressant principles of the roots of polygala tenuifolia. Journal of Natural Products, 69(9), 1305-1309. https://doi.org/10.1021/np060207r