Antihaemostatic and antithrombotic effect of some antiplatelet agents isolated from Chinese herbs

CHE‐MING ‐M TENG, FENG‐NIEN ‐N KO, JIH‐PYANG ‐P WANG, CHUN‐NAN ‐N LIN, Tian-Shung Wu, CHIEN‐CHIH ‐C CHEN, TUR‐FU ‐F HUANG

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Abstract

Abstract— Five antiplatelet agents have been isolated from Chinese herbs. Apigenin and magnolol are inhibitors of thromboxane synthesis, while osthole, protopine and norathyriol are inhibitors of phosphoinositide breakdown. Thirty min after intraperitoneal (i.p.) administration of these drugs, tail bleeding time of mice was prolonged markedly in a dose‐dependent manner by norathyriol, protopine, osthole and magnolol, but not by apigenin. However, the antiplatelet agents (up to 200 mg kg−1, i.p.) could not prevent acute thromboembolic death in mice. In endotoxin‐induced experimental disseminated intravascular coagulation in rats, norathyriol (50–100 mg kg−1, i.p.) prevented the decrease in platelet counts and fibrinogen, and the prolongation of plasma prothrombin time. Norathyriol (100 mg kg−1, i.p.) also suppressed ex‐vivo platelet aggregation induced by collagen and ADP in rat plasma. 1991 Royal Pharmaceutical Society of Great Britain

Original languageEnglish
Pages (from-to)667-669
Number of pages3
JournalJournal of Pharmacy and Pharmacology
Volume43
Issue number9
DOIs
Publication statusPublished - 1991 Jan 1

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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