Antiinflammatory triterpenoids from the fruiting bodies of Fomitopsis pinicola

Ping Chung Kuo, Shih Huang Tai, Ching Che Hung, Tsong Long Hwang, Liang Mou Kuo, Sio Hong Lam, Kun Ching Cheng, Daih Huang Kuo, Hsin Yi Hung, Tian Shung Wu

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Twelve undescribed lanostane-type triterpenes, and twenty-two known triterpenes were isolated and identified from a medicinal bracket fungus Fomitopsis pinicola (Sw.) P. Karst. The structures of these compounds were determined by spectroscopic and spectrometric analyses. The antiinflammatory potential of thirty-two triterpene compounds was evaluated using neutrophils as an assay model, and pinicolasin J was the most potent inhibitor of superoxide anion generation and elastase release, with IC50 values of 1.81 ± 0.44 and 2.50 ± 0.64 μM, respectively. This study provides scientific insight into the nutritional supplement value and medicinal development of Fomitopsis pinicola.

Original languageEnglish
Article number104562
JournalBioorganic Chemistry
Volume108
DOIs
Publication statusPublished - 2021 Mar

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Drug Discovery
  • Organic Chemistry

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