Antiinflammatory triterpenoids from the fruiting bodies of Fomitopsis pinicola

Ping Chung Kuo; Shih Huang Tai; Ching Che Hung; Tsong Long Hwang; Liang Mou Kuo; Sio Hong Lam; Kun Ching Cheng; Daih Huang Kuo; Hsin Yi Hung; Tian Shung Wu

doi:10.1016/j.bioorg.2020.104562

Antiinflammatory triterpenoids from the fruiting bodies of Fomitopsis pinicola

Ping Chung Kuo, Shih Huang Tai, Ching Che Hung, Tsong Long Hwang, Liang Mou Kuo, Sio Hong Lam, Kun Ching Cheng, Daih Huang Kuo, Hsin Yi Hung, Tian Shung Wu

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Twelve undescribed lanostane-type triterpenes, and twenty-two known triterpenes were isolated and identified from a medicinal bracket fungus Fomitopsis pinicola (Sw.) P. Karst. The structures of these compounds were determined by spectroscopic and spectrometric analyses. The antiinflammatory potential of thirty-two triterpene compounds was evaluated using neutrophils as an assay model, and pinicolasin J was the most potent inhibitor of superoxide anion generation and elastase release, with IC₅₀ values of 1.81 ± 0.44 and 2.50 ± 0.64 μM, respectively. This study provides scientific insight into the nutritional supplement value and medicinal development of Fomitopsis pinicola.

Original language	English
Article number	104562
Journal	Bioorganic Chemistry
Volume	108
DOIs	https://doi.org/10.1016/j.bioorg.2020.104562
Publication status	Published - 2021 Mar

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Drug Discovery
Organic Chemistry

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10.1016/j.bioorg.2020.104562

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title = "Antiinflammatory triterpenoids from the fruiting bodies of Fomitopsis pinicola",

abstract = "Twelve undescribed lanostane-type triterpenes, and twenty-two known triterpenes were isolated and identified from a medicinal bracket fungus Fomitopsis pinicola (Sw.) P. Karst. The structures of these compounds were determined by spectroscopic and spectrometric analyses. The antiinflammatory potential of thirty-two triterpene compounds was evaluated using neutrophils as an assay model, and pinicolasin J was the most potent inhibitor of superoxide anion generation and elastase release, with IC50 values of 1.81 ± 0.44 and 2.50 ± 0.64 μM, respectively. This study provides scientific insight into the nutritional supplement value and medicinal development of Fomitopsis pinicola.",

author = "Kuo, {Ping Chung} and Tai, {Shih Huang} and Hung, {Ching Che} and Hwang, {Tsong Long} and Kuo, {Liang Mou} and Lam, {Sio Hong} and Cheng, {Kun Ching} and Kuo, {Daih Huang} and Hung, {Hsin Yi} and Wu, {Tian Shung}",

note = "Funding Information: This study was sponsored by the Ministry of Science and Technology, Taiwan. Authors are thankful to Chang Gung Memorial Hospital (CMRPD1B0281~3, CMRPF1D0442~3, CMRPF 1F0011~3, CMRPF1F0061~3 and BMRP450 granted to T.-L.H.) for the partial financial support of the present study. Thanks Dr. He-Ping Chen at School of Pharmaceutical Sciences, South-Central University for Nationalities for correcting some mistakes. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2021",

month = mar,

doi = "10.1016/j.bioorg.2020.104562",

language = "English",

volume = "108",

journal = "Bioorganic Chemistry",

issn = "0045-2068",

publisher = "Academic Press Inc.",

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AU - Kuo, Ping Chung

AU - Tai, Shih Huang

AU - Hung, Ching Che

AU - Hwang, Tsong Long

AU - Kuo, Liang Mou

AU - Lam, Sio Hong

AU - Cheng, Kun Ching

AU - Kuo, Daih Huang

AU - Hung, Hsin Yi

AU - Wu, Tian Shung

N1 - Funding Information: This study was sponsored by the Ministry of Science and Technology, Taiwan. Authors are thankful to Chang Gung Memorial Hospital (CMRPD1B0281~3, CMRPF1D0442~3, CMRPF 1F0011~3, CMRPF1F0061~3 and BMRP450 granted to T.-L.H.) for the partial financial support of the present study. Thanks Dr. He-Ping Chen at School of Pharmaceutical Sciences, South-Central University for Nationalities for correcting some mistakes. Publisher Copyright: © 2020 Elsevier Inc.

PY - 2021/3

Y1 - 2021/3

N2 - Twelve undescribed lanostane-type triterpenes, and twenty-two known triterpenes were isolated and identified from a medicinal bracket fungus Fomitopsis pinicola (Sw.) P. Karst. The structures of these compounds were determined by spectroscopic and spectrometric analyses. The antiinflammatory potential of thirty-two triterpene compounds was evaluated using neutrophils as an assay model, and pinicolasin J was the most potent inhibitor of superoxide anion generation and elastase release, with IC50 values of 1.81 ± 0.44 and 2.50 ± 0.64 μM, respectively. This study provides scientific insight into the nutritional supplement value and medicinal development of Fomitopsis pinicola.

AB - Twelve undescribed lanostane-type triterpenes, and twenty-two known triterpenes were isolated and identified from a medicinal bracket fungus Fomitopsis pinicola (Sw.) P. Karst. The structures of these compounds were determined by spectroscopic and spectrometric analyses. The antiinflammatory potential of thirty-two triterpene compounds was evaluated using neutrophils as an assay model, and pinicolasin J was the most potent inhibitor of superoxide anion generation and elastase release, with IC50 values of 1.81 ± 0.44 and 2.50 ± 0.64 μM, respectively. This study provides scientific insight into the nutritional supplement value and medicinal development of Fomitopsis pinicola.

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VL - 108

JO - Bioorganic Chemistry

JF - Bioorganic Chemistry

M1 - 104562

ER -

Antiinflammatory triterpenoids from the fruiting bodies of Fomitopsis pinicola

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