Antiinflammatory triterpenoids from the fruiting bodies of Fomitopsis pinicola

Ping Chung Kuo, Shih-Huang Tai, Ching Che Hung, Tsong Long Hwang, Liang Mou Kuo, Sio-Hong Lam, Kun Ching Cheng, Daih Huang Kuo, Hsin Yi Hung, Tian Shung Wu

Research output: Contribution to journalArticlepeer-review

Abstract

Twelve undescribed lanostane-type triterpenes, and twenty-two known triterpenes were isolated and identified from a medicinal bracket fungus Fomitopsis pinicola (Sw.) P. Karst. The structures of these compounds were determined by spectroscopic and spectrometric analyses. The antiinflammatory potential of thirty-two triterpene compounds was evaluated using neutrophils as an assay model, and pinicolasin J was the most potent inhibitor of superoxide anion generation and elastase release, with IC50 values of 1.81 ± 0.44 and 2.50 ± 0.64 μM, respectively. This study provides scientific insight into the nutritional supplement value and medicinal development of Fomitopsis pinicola.

Original languageEnglish
Article number104562
JournalBioorganic Chemistry
DOIs
Publication statusAccepted/In press - 2020

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Antiinflammatory triterpenoids from the fruiting bodies of Fomitopsis pinicola'. Together they form a unique fingerprint.

Cite this