Antimalarial primaquine for skin infiltration analgesia in rats

Ying Jen Chang, Kuo Sheng Liu, Jhi Joung Wang, Yu Wen Chen, Ching Hsia Hung

Research output: Contribution to journalArticlepeer-review


OBJECTIVES: The purpose of this study was to estimate the ability of antimalarial medications to induce local infiltration analgesia. METHODS: Using a rat model of skin infiltration anaesthesia, the effects of antimalarial medications (primaquine, chloroquine, hydroxychloroquine and amodiaquine) were compared with the application of lidocaine. KEY FINDINGS: At a dose of 3 μmol, primaquine and chloroquine displayed better potency (all P < 0.05) and greater duration (all P < 0.01) of cutaneous analgesia than lidocaine, whereas the other antimalarial medications showed a similar potency and duration of cutaneous analgesia when compared with lidocaine. When a dose of 3 μmol antimalarial medication was used, primaquine was the most potent and had the longest duration of action among four antimalarial medications. The relative potency ranking (ED50, 50% effective dose) has been found to be primaquine [2.10 (1.87 - 2.37) μmol] > lidocaine [6.27 (5.32 -7.39) μmol] (P < 0.01). Infiltration analgesia of skin with primaquine had a greater duration of action than did lidocaine on the equipotent (ED25, ED50, ED75) basis (P < 0.01). CONCLUSIONS: Primaquine and chloroquine have greater potency and longer lasting skin analgesia when compared with lidocaine, while the other antimalarials display a similar potency in comparison with lidocaine.

Original languageEnglish
Pages (from-to)206-211
Number of pages6
JournalJournal of Pharmacy and Pharmacology
Issue number2
Publication statusPublished - 2021 Mar 4

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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