Antimalarial primaquine for spinal sensory and motor blockade in rats

An Kuo Chou, Chong Chi Chiu, Jhi Joung Wang, Yu Wen Chen, Ching Hsia Hung

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Objectives The purpose of the experiment was to estimate whether intrathecal antimalarial drugs could provoke spinal block, and their comparison with lidocaine. Methods Rats were intrathecally administrated with antimalarial agents (primaquine, chloroquine, hydroxychloroquine and amodiaquine) and lidocaine, and neurobehavioural examinations (nociception, proprioception and motor function) were assessed; n = 8 per group. One-way and two-way analysis of variance were designed to analyse data. Key findings At a concentration of 20 mM, primaquine (0.46 mg/rat) exhibited the longest duration and the most potent effect of nociceptive, proprioceptive and motor blockade (P < 0.01) among five drugs, whereas the other antimalarial drugs displayed a lesser or similar potency of spinal blockade compared with lidocaine (0.29 mg/rat). In dose-dependent studies, primaquine was more potent (P < 0.01) than lidocaine for spinal block. At ED25, ED50 and ED75 equipotent doses, primaquine produced a greater duration of spinal motor, proprioceptive and nociceptive blockade when compared with lidocaine (P < 0.01). Conclusions Primaquine, chloroquine, hydroxychloroquine and amodiaquine produced spinal blockade. Primaquine was more potent and displayed a prolonged life of local anaesthetic effect compared with lidocaine, whereas the other antimalarial drugs displayed a lesser or similar potency compared with lidocaine.

Original languageEnglish
Pages (from-to)1513-1519
Number of pages7
JournalJournal of Pharmacy and Pharmacology
Volume73
Issue number11
DOIs
Publication statusPublished - 2021 Nov 1

All Science Journal Classification (ASJC) codes

  • General Medicine

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