Antimicrobial resistance of bacterial isolates from respiratory care wards in Taiwan: a horizontal surveillance study

Lu Cheng Kuo, Chong Jen Yu, Ming Long Kuo, Wei Nan Chen, Chee Kong Chang, Hen I. Lin, Chih Chiang Chen, Min Chi Lu, Ching Hsiung Lin, Wu Feng Hsieh, Liang Wu Chen, Yih Chou, Ming Shian Huang, Cheng Hsiung Lee, Shen Chun Chen, Sun Lung Thai, Po Chung Chen, Ching Hsiung Chen, Chung Chia Tseng, Yao Shen ChenTzuen Ren Hsiue, Po Ren Hsueh

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

A horizontal surveillance study was conducted to identify common bacteria and mycobacteria from 611 respiratory aspirates and 165 urinary samples from 611 patients hospitalised at 17 respiratory care wards (RCWs) in Taiwan. Some major resistance phenotypes, including meticillin-resistant Staphylococcus aureus (MRSA), extended-spectrum β-lactamase (ESBL)-producing Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis, and multidrug-resistant Pseudomonas aeruginosa (MDR-PA) and Acinetobacter baumannii (MDR-AB), were identified. Pulsotypes of ESBL-producing P. mirabilis isolates were determined by pulsed-field gel electrophoresis. The prevalences of MRSA, ESBL-producing E. coli (K. pneumoniae and P. mirabilis), carbapenem-resistant (resistant to imipenem and meropenem) P. aeruginosa, MDR-PA, carbapenem-resistant A. baumannii and MDR-AB were, respectively, 86.7%, 20.0% (50.7% and 24.1%), 18.4%, 1.2%, 32.1% and 8.9% for respiratory aspirates and 100%, 25.4% (27.3% and 25.0%), 48.3%, 10.3%, 50.0% and 21.4% for catheterised urinary samples. Among the 44 respiratory isolates of P. mirabilis with an ESBL phenotype, 22 different pulsotypes (>80% identity) were identified. Among 103 isolates of mycobacteria, 90 (87.4%) belonged to rapidly growing mycobacteria and 4 (4%) were Mycobacterium tuberculosis. Among the 404 patients with available clinical information, true infections were found in 28.0%, the most prevalent of which were urinary tract infection (20.5%) and ventilator-associated pneumonia (10.9%). High prevalences of various multidrug-resistant bacteria among the respiratory and urinary tracts of patients present a clinical difficulty in choosing empirical antibiotic treatment in RCWs.

Original languageEnglish
Pages (from-to)420-426
Number of pages7
JournalInternational journal of antimicrobial agents
Volume31
Issue number5
DOIs
Publication statusPublished - 2008 May

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

Fingerprint

Dive into the research topics of 'Antimicrobial resistance of bacterial isolates from respiratory care wards in Taiwan: a horizontal surveillance study'. Together they form a unique fingerprint.

Cite this