Antimicrobial susceptibility of bacteremic isolates from cancer patients with or without neutropenia at a medical center in southern Taiwan

Chi-Chang Wuang, Chi Jung Wu, Li Rong Wang, Hsin Chun Lee, Chia-Ming Chang, Nan-Yao Lee, Tsai-Yun Chen, Wen-Chien Ko

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Few studies focus on comparison of antimicrobial susceptibility for bacteremic isolates in neutropenic and nonneutropenic cancer patients. The purpose of this study was to elucidate the antimicrobial susceptibility of bacteremic isolates from cancer patients. Methods: We collected bacterial isolates causing bloodstream infections in cancer patients at a tertiary care hospital from 2003 to 2005 and performed in vitro antimicrobial susceptibility of these pathogens by the disc diffusion method. Results: A total of 588 bacterial isolates were identified from 476 episodes of bloodstream infections in cancer patients. Major pathogens were Escherichia coli (22.4%), Klebsiella pneumoniae (17.6%), and Pseudomonas aeruginosa (14.1%) in neutropenic patients and E coli (13.3%), K pneumoniae (10.1%), and Staphylococcus aureus (9.7%) in nonneutropenic patients. Of S aureus, 55.8% were resistant to methicillin, and of coagulase-negative Staphylococcus 87.0%. Cefepime, cefpirome, piperacillin/tazobactam, meropenem, or imipenem in combination with or without an aminoglycoside, were active against more than 85% of gram-negative bacilli (GNB). Ceftazidime, piperacillin, or ciprofloxacin plus an aminoglycoside were also active against more than 85% of GNB. The susceptibility rate of GNB or gram-positive cocci to any agent was not different between the isolates from neutropenic and nonneutropenic patients, but more GNB isolates from the former were susceptible to imipenem or meropenem plus an aminoglycoside. Conclusion: GNB remained dominant among bacteremic isolates in cancer patients. Antimicrobial agents, especially aminoglycoside-containing combination regimens, as recommended by Infectious Diseases Society of Taiwan for febrile neutropenia, were active against more than 85% of GNB isolates.

Original languageEnglish
Pages (from-to)376-381
Number of pages6
JournalJournal of Microbiology, Immunology and Infection
Volume44
Issue number5
DOIs
Publication statusPublished - 2011 Oct 1

Fingerprint

Neutropenia
Taiwan
Bacillus
meropenem
Aminoglycosides
Neoplasms
cefpirome
Imipenem
Staphylococcal Pneumonia
Escherichia coli
Gram-Positive Cocci
Febrile Neutropenia
Piperacillin
Methicillin Resistance
Ceftazidime
Coagulase
Klebsiella pneumoniae
Tertiary Healthcare
Ciprofloxacin
Anti-Infective Agents

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

Cite this

@article{58b44220b9414455ae59b36de76f1a25,
title = "Antimicrobial susceptibility of bacteremic isolates from cancer patients with or without neutropenia at a medical center in southern Taiwan",
abstract = "Background: Few studies focus on comparison of antimicrobial susceptibility for bacteremic isolates in neutropenic and nonneutropenic cancer patients. The purpose of this study was to elucidate the antimicrobial susceptibility of bacteremic isolates from cancer patients. Methods: We collected bacterial isolates causing bloodstream infections in cancer patients at a tertiary care hospital from 2003 to 2005 and performed in vitro antimicrobial susceptibility of these pathogens by the disc diffusion method. Results: A total of 588 bacterial isolates were identified from 476 episodes of bloodstream infections in cancer patients. Major pathogens were Escherichia coli (22.4{\%}), Klebsiella pneumoniae (17.6{\%}), and Pseudomonas aeruginosa (14.1{\%}) in neutropenic patients and E coli (13.3{\%}), K pneumoniae (10.1{\%}), and Staphylococcus aureus (9.7{\%}) in nonneutropenic patients. Of S aureus, 55.8{\%} were resistant to methicillin, and of coagulase-negative Staphylococcus 87.0{\%}. Cefepime, cefpirome, piperacillin/tazobactam, meropenem, or imipenem in combination with or without an aminoglycoside, were active against more than 85{\%} of gram-negative bacilli (GNB). Ceftazidime, piperacillin, or ciprofloxacin plus an aminoglycoside were also active against more than 85{\%} of GNB. The susceptibility rate of GNB or gram-positive cocci to any agent was not different between the isolates from neutropenic and nonneutropenic patients, but more GNB isolates from the former were susceptible to imipenem or meropenem plus an aminoglycoside. Conclusion: GNB remained dominant among bacteremic isolates in cancer patients. Antimicrobial agents, especially aminoglycoside-containing combination regimens, as recommended by Infectious Diseases Society of Taiwan for febrile neutropenia, were active against more than 85{\%} of GNB isolates.",
author = "Chi-Chang Wuang and Wu, {Chi Jung} and Wang, {Li Rong} and Lee, {Hsin Chun} and Chia-Ming Chang and Nan-Yao Lee and Tsai-Yun Chen and Wen-Chien Ko",
year = "2011",
month = "10",
day = "1",
doi = "10.1016/j.jmii.2011.01.035",
language = "English",
volume = "44",
pages = "376--381",
journal = "Journal of Microbiology, Immunology and Infection",
issn = "1684-1182",
publisher = "Elsevier Taiwan LLC",
number = "5",

}

TY - JOUR

T1 - Antimicrobial susceptibility of bacteremic isolates from cancer patients with or without neutropenia at a medical center in southern Taiwan

AU - Wuang, Chi-Chang

AU - Wu, Chi Jung

AU - Wang, Li Rong

AU - Lee, Hsin Chun

AU - Chang, Chia-Ming

AU - Lee, Nan-Yao

AU - Chen, Tsai-Yun

AU - Ko, Wen-Chien

PY - 2011/10/1

Y1 - 2011/10/1

N2 - Background: Few studies focus on comparison of antimicrobial susceptibility for bacteremic isolates in neutropenic and nonneutropenic cancer patients. The purpose of this study was to elucidate the antimicrobial susceptibility of bacteremic isolates from cancer patients. Methods: We collected bacterial isolates causing bloodstream infections in cancer patients at a tertiary care hospital from 2003 to 2005 and performed in vitro antimicrobial susceptibility of these pathogens by the disc diffusion method. Results: A total of 588 bacterial isolates were identified from 476 episodes of bloodstream infections in cancer patients. Major pathogens were Escherichia coli (22.4%), Klebsiella pneumoniae (17.6%), and Pseudomonas aeruginosa (14.1%) in neutropenic patients and E coli (13.3%), K pneumoniae (10.1%), and Staphylococcus aureus (9.7%) in nonneutropenic patients. Of S aureus, 55.8% were resistant to methicillin, and of coagulase-negative Staphylococcus 87.0%. Cefepime, cefpirome, piperacillin/tazobactam, meropenem, or imipenem in combination with or without an aminoglycoside, were active against more than 85% of gram-negative bacilli (GNB). Ceftazidime, piperacillin, or ciprofloxacin plus an aminoglycoside were also active against more than 85% of GNB. The susceptibility rate of GNB or gram-positive cocci to any agent was not different between the isolates from neutropenic and nonneutropenic patients, but more GNB isolates from the former were susceptible to imipenem or meropenem plus an aminoglycoside. Conclusion: GNB remained dominant among bacteremic isolates in cancer patients. Antimicrobial agents, especially aminoglycoside-containing combination regimens, as recommended by Infectious Diseases Society of Taiwan for febrile neutropenia, were active against more than 85% of GNB isolates.

AB - Background: Few studies focus on comparison of antimicrobial susceptibility for bacteremic isolates in neutropenic and nonneutropenic cancer patients. The purpose of this study was to elucidate the antimicrobial susceptibility of bacteremic isolates from cancer patients. Methods: We collected bacterial isolates causing bloodstream infections in cancer patients at a tertiary care hospital from 2003 to 2005 and performed in vitro antimicrobial susceptibility of these pathogens by the disc diffusion method. Results: A total of 588 bacterial isolates were identified from 476 episodes of bloodstream infections in cancer patients. Major pathogens were Escherichia coli (22.4%), Klebsiella pneumoniae (17.6%), and Pseudomonas aeruginosa (14.1%) in neutropenic patients and E coli (13.3%), K pneumoniae (10.1%), and Staphylococcus aureus (9.7%) in nonneutropenic patients. Of S aureus, 55.8% were resistant to methicillin, and of coagulase-negative Staphylococcus 87.0%. Cefepime, cefpirome, piperacillin/tazobactam, meropenem, or imipenem in combination with or without an aminoglycoside, were active against more than 85% of gram-negative bacilli (GNB). Ceftazidime, piperacillin, or ciprofloxacin plus an aminoglycoside were also active against more than 85% of GNB. The susceptibility rate of GNB or gram-positive cocci to any agent was not different between the isolates from neutropenic and nonneutropenic patients, but more GNB isolates from the former were susceptible to imipenem or meropenem plus an aminoglycoside. Conclusion: GNB remained dominant among bacteremic isolates in cancer patients. Antimicrobial agents, especially aminoglycoside-containing combination regimens, as recommended by Infectious Diseases Society of Taiwan for febrile neutropenia, were active against more than 85% of GNB isolates.

UR - http://www.scopus.com/inward/record.url?scp=80053620310&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80053620310&partnerID=8YFLogxK

U2 - 10.1016/j.jmii.2011.01.035

DO - 10.1016/j.jmii.2011.01.035

M3 - Article

C2 - 21524977

AN - SCOPUS:80053620310

VL - 44

SP - 376

EP - 381

JO - Journal of Microbiology, Immunology and Infection

JF - Journal of Microbiology, Immunology and Infection

SN - 1684-1182

IS - 5

ER -