TY - JOUR
T1 - Antiplatelet aggregation principles from Glycosmis citrifolia
AU - Leu, Yann Lii
AU - Chan, Yu Yi
AU - Wu, Tian Shung
AU - Teng, Che Ming
AU - Chen, Kuo Tung
PY - 1998/1/1
Y1 - 1998/1/1
N2 - Twelve acridone alkaloids, citracridone-I (1), atalaphyllidine (2), noracronycine (3), des-N-methyl-noracronycine (4), 5-hydroxynor-acronycine (5), des-N-methylacronycine (6), N-methyl severifoline (7), 5-hydroxy-N- methyl severifoline (8), glycocitrine-II (9), 3-O-methyl-glycocitrine-II (10), glycocitrine-I (11) and pyranofoline (12); one 2-quinolone alkaloid, 4,8-dimethoxy-1-methyl-3(3-methylbut-2-enyl)2-quinolone (13) were isolated and characterized from the stem and root barks of Glycosmis citrifolia. Their structures were determined by spectral analyses. On bioactive evaluation, compounds 1 and 2 almost completely inhibited platelet aggregation induced by arachidonic acid (100 μM), collagen (10 μg/mL) and PAF (2 ng/mL). Compounds 2, 4 and 13 also showed an inhibitory effect on AA and collagen-induced rabbit platelet aggregation. In the structure and activity relationship of acridone alkaloids, the acridone nucleus bearing a pyranyl moiety is a most important factor for the antiplatelet aggregation activity.
AB - Twelve acridone alkaloids, citracridone-I (1), atalaphyllidine (2), noracronycine (3), des-N-methyl-noracronycine (4), 5-hydroxynor-acronycine (5), des-N-methylacronycine (6), N-methyl severifoline (7), 5-hydroxy-N- methyl severifoline (8), glycocitrine-II (9), 3-O-methyl-glycocitrine-II (10), glycocitrine-I (11) and pyranofoline (12); one 2-quinolone alkaloid, 4,8-dimethoxy-1-methyl-3(3-methylbut-2-enyl)2-quinolone (13) were isolated and characterized from the stem and root barks of Glycosmis citrifolia. Their structures were determined by spectral analyses. On bioactive evaluation, compounds 1 and 2 almost completely inhibited platelet aggregation induced by arachidonic acid (100 μM), collagen (10 μg/mL) and PAF (2 ng/mL). Compounds 2, 4 and 13 also showed an inhibitory effect on AA and collagen-induced rabbit platelet aggregation. In the structure and activity relationship of acridone alkaloids, the acridone nucleus bearing a pyranyl moiety is a most important factor for the antiplatelet aggregation activity.
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U2 - 10.1002/(SICI)1099-1573(1998)12:1+<S77::AID-PTR256>3.0.CO;2-J
DO - 10.1002/(SICI)1099-1573(1998)12:1+<S77::AID-PTR256>3.0.CO;2-J
M3 - Article
AN - SCOPUS:0031708129
SN - 0951-418X
VL - 12
SP - S77-S79
JO - Phytotherapy Research
JF - Phytotherapy Research
IS - SUPPL. 1
ER -