Antiplatelet principles from the root of Petasites formosanus

Tian Shung Wu; Mang San Kao; Pei Lin Wu; Fu Wen Lin; Li Shian Shi; Che Ming Teng

doi:10.1016/S0031-9422(99)00333-7

Antiplatelet principles from the root of Petasites formosanus

Tian Shung Wu, Mang San Kao, Pei Lin Wu, Fu Wen Lin, Li Shian Shi, Che Ming Teng

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Three bakkenolide-type compounds, bakkenolides-G, -H and deisobutyryl bakkenolide-H were isolated from the roots of Petasites formosanus. The structures were characterized by spectral methods. Bakkenolide-G and -H showed inhibitory activity against platelet activation factor (PAF), whereas deisobutyryl bakkenolide-H and ferulic acid showed inhibitory activity against arachidonic acid (AA) and collagen (Col)-induced aggregation of washed rabbit platelets.

Original language	English
Pages (from-to)	901-905
Number of pages	5
Journal	Phytochemistry
Volume	52
Issue number	5
DOIs	https://doi.org/10.1016/S0031-9422(99)00333-7
Publication status	Published - 1999 Nov

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Plant Science
Horticulture

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10.1016/S0031-9422(99)00333-7

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title = "Antiplatelet principles from the root of Petasites formosanus",

abstract = "Three bakkenolide-type compounds, bakkenolides-G, -H and deisobutyryl bakkenolide-H were isolated from the roots of Petasites formosanus. The structures were characterized by spectral methods. Bakkenolide-G and -H showed inhibitory activity against platelet activation factor (PAF), whereas deisobutyryl bakkenolide-H and ferulic acid showed inhibitory activity against arachidonic acid (AA) and collagen (Col)-induced aggregation of washed rabbit platelets.",

author = "Wu, {Tian Shung} and Kao, {Mang San} and Wu, {Pei Lin} and Lin, {Fu Wen} and Shi, {Li Shian} and Teng, {Che Ming}",

note = "Funding Information: We thank the National Science Council, ROC (NSC 85-2331-B-006-098-M25) for support of this research. Copyright: Copyright 2004 Elsevier Science B.V., Amsterdam. All rights reserved.",

year = "1999",

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doi = "10.1016/S0031-9422(99)00333-7",

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T1 - Antiplatelet principles from the root of Petasites formosanus

AU - Wu, Tian Shung

AU - Kao, Mang San

AU - Wu, Pei Lin

AU - Lin, Fu Wen

AU - Shi, Li Shian

AU - Teng, Che Ming

N1 - Funding Information: We thank the National Science Council, ROC (NSC 85-2331-B-006-098-M25) for support of this research. Copyright: Copyright 2004 Elsevier Science B.V., Amsterdam. All rights reserved.

PY - 1999/11

Y1 - 1999/11

N2 - Three bakkenolide-type compounds, bakkenolides-G, -H and deisobutyryl bakkenolide-H were isolated from the roots of Petasites formosanus. The structures were characterized by spectral methods. Bakkenolide-G and -H showed inhibitory activity against platelet activation factor (PAF), whereas deisobutyryl bakkenolide-H and ferulic acid showed inhibitory activity against arachidonic acid (AA) and collagen (Col)-induced aggregation of washed rabbit platelets.

AB - Three bakkenolide-type compounds, bakkenolides-G, -H and deisobutyryl bakkenolide-H were isolated from the roots of Petasites formosanus. The structures were characterized by spectral methods. Bakkenolide-G and -H showed inhibitory activity against platelet activation factor (PAF), whereas deisobutyryl bakkenolide-H and ferulic acid showed inhibitory activity against arachidonic acid (AA) and collagen (Col)-induced aggregation of washed rabbit platelets.

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JO - Phytochemistry

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Antiplatelet principles from the root of Petasites formosanus

Abstract

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