Antitumor agents, 112.1 emarginatine Β, a novel potent cytotoxic sesquiterpene pyridine alkaloid from maytenus emarginata

Yao Haur Kuo; Chung Hsiung Chen; Li Ming Yang Kuo; Ming Lu King; Tian Shung Wu; Mitsumasa Haruna; Kuo Hsiung Lee

doi:10.1021/np50068a021

Antitumor agents, 112.¹ emarginatine Β, a novel potent cytotoxic sesquiterpene pyridine alkaloid from maytenus emarginata

Yao Haur Kuo, Chung Hsiung Chen, Li Ming Yang Kuo, Ming Lu King, Tian Shung Wu, Mitsumasa Haruna, Kuo Hsiung Lee

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

A new sesquiterpene pyridine alkaloid, emarginatine Β [2] has been isolated, along with maytansine [3], from Maytenus emarginata. Emarginatine Β showed potent cytotoxicity against human KB cells (ED₅₀ = 0.4 μg/ml). Spectral correlations established its structure as a 9-benzoate and C-8 epimer of emarginatine A [1]. The conformational aspect of the latter compound was elucidated by nmr studies, including the use of 2D-nmr techniques and difference nOe methods.

Original language	English
Pages (from-to)	422-428
Number of pages	7
Journal	Journal of Natural Products
Volume	53
Issue number	2
DOIs	https://doi.org/10.1021/np50068a021
Publication status	Published - 1990

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np50068a021

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title = "Antitumor agents, 112.1 emarginatine Β, a novel potent cytotoxic sesquiterpene pyridine alkaloid from maytenus emarginata",

abstract = "A new sesquiterpene pyridine alkaloid, emarginatine Β [2] has been isolated, along with maytansine [3], from Maytenus emarginata. Emarginatine Β showed potent cytotoxicity against human KB cells (ED50 = 0.4 μg/ml). Spectral correlations established its structure as a 9-benzoate and C-8 epimer of emarginatine A [1]. The conformational aspect of the latter compound was elucidated by nmr studies, including the use of 2D-nmr techniques and difference nOe methods.",

author = "Kuo, {Yao Haur} and Chen, {Chung Hsiung} and {Yang Kuo}, {Li Ming} and King, {Ming Lu} and Wu, {Tian Shung} and Mitsumasa Haruna and Lee, {Kuo Hsiung}",

year = "1990",

doi = "10.1021/np50068a021",

language = "English",

volume = "53",

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T1 - Antitumor agents, 112.1 emarginatine Β, a novel potent cytotoxic sesquiterpene pyridine alkaloid from maytenus emarginata

AU - Kuo, Yao Haur

AU - Chen, Chung Hsiung

AU - Yang Kuo, Li Ming

AU - King, Ming Lu

AU - Wu, Tian Shung

AU - Haruna, Mitsumasa

AU - Lee, Kuo Hsiung

PY - 1990

Y1 - 1990

N2 - A new sesquiterpene pyridine alkaloid, emarginatine Β [2] has been isolated, along with maytansine [3], from Maytenus emarginata. Emarginatine Β showed potent cytotoxicity against human KB cells (ED50 = 0.4 μg/ml). Spectral correlations established its structure as a 9-benzoate and C-8 epimer of emarginatine A [1]. The conformational aspect of the latter compound was elucidated by nmr studies, including the use of 2D-nmr techniques and difference nOe methods.

AB - A new sesquiterpene pyridine alkaloid, emarginatine Β [2] has been isolated, along with maytansine [3], from Maytenus emarginata. Emarginatine Β showed potent cytotoxicity against human KB cells (ED50 = 0.4 μg/ml). Spectral correlations established its structure as a 9-benzoate and C-8 epimer of emarginatine A [1]. The conformational aspect of the latter compound was elucidated by nmr studies, including the use of 2D-nmr techniques and difference nOe methods.

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Antitumor agents, 112.¹ emarginatine Β, a novel potent cytotoxic sesquiterpene pyridine alkaloid from maytenus emarginata

Abstract

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