Antitumor agents, 112.1 emarginatine Β, a novel potent cytotoxic sesquiterpene pyridine alkaloid from maytenus emarginata

Yao Haur Kuo, Chung Hsiung Chen, Li Ming Yang Kuo, Ming Lu King, Tian Shung Wu, Mitsumasa Haruna, Kuo Hsiung Lee

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41 Citations (Scopus)

Abstract

A new sesquiterpene pyridine alkaloid, emarginatine Β [2] has been isolated, along with maytansine [3], from Maytenus emarginata. Emarginatine Β showed potent cytotoxicity against human KB cells (ED50 = 0.4 μg/ml). Spectral correlations established its structure as a 9-benzoate and C-8 epimer of emarginatine A [1]. The conformational aspect of the latter compound was elucidated by nmr studies, including the use of 2D-nmr techniques and difference nOe methods.

Original languageEnglish
Pages (from-to)422-428
Number of pages7
JournalJournal of Natural Products
Volume53
Issue number2
DOIs
Publication statusPublished - 1990

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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