Two novel prenylated acetophenone dimers, acrofoliones A (1) and B (2), were isolated from Acronychia trifoliolata (Rutaceae) together with a known cytotoxic principle, acrovestone (3). The new structures were determined from NMR and MS spectroscopic analysis. Compounds 1 and 2 showed only moderate cytotoxicity against HCT-8 and KB cells with ED50 values of 4.3 and 4.8 μg/mL, respectively; however, both compounds demonstrated selectivity against MOLT-4 and RPMI-8225 leukemia cell lines.
|Number of pages||7|
|Journal||Chinese Pharmaceutical Journal|
|Publication status||Published - 2003 Aug 1|
All Science Journal Classification (ASJC) codes
- Pharmaceutical Science