Antitumor agents 225. Acrofoliones A and B, two novel cytotoxic acetophenone dimers, from Acronychia trifoliolata

Masayoshi Oyama, Kenneth F. Bastow, Yoko Tachibana, Yoshiaki Shirataki, Sadaki Yamaguchi, Gordon M. Cragg, Tian Shung Wu, Kuo Hsiung Lee

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Two novel prenylated acetophenone dimers, acrofoliones A (1) and B (2), were isolated from Acronychia trifoliolata (Rutaceae) together with a known cytotoxic principle, acrovestone (3). The new structures were determined from NMR and MS spectroscopic analysis. Compounds 1 and 2 showed only moderate cytotoxicity against HCT-8 and KB cells with ED50 values of 4.3 and 4.8 μg/mL, respectively; however, both compounds demonstrated selectivity against MOLT-4 and RPMI-8225 leukemia cell lines.

Original languageEnglish
Pages (from-to)239-245
Number of pages7
JournalChinese Pharmaceutical Journal
Volume55
Issue number4
Publication statusPublished - 2003 Aug 1

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'Antitumor agents 225. Acrofoliones A and B, two novel cytotoxic acetophenone dimers, from Acronychia trifoliolata'. Together they form a unique fingerprint.

Cite this