Antitumor agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza

Xihong Wang, Kenneth F. Bastow, Chang Ming Sun, Yun Lian Lin, Hsi Jung Yu, Ming Jaw Don, Tian Shung Wu, Seikou Nakamura, Kuo Hsiung Lee

Research output: Contribution to journalArticle

167 Citations (Scopus)

Abstract

Neo-tanshinlactone (1) was isolated and synthesized for the first time and evaluated in vitro against several human cancer cell lines. Compound 1 showed significant inhibition against two ER+ human breast cancer cell lines and was 10-fold more potent and 20-fold more selective as compared to tamoxifen citrate. Compound 1 also potently inhibited an ER-, HER-2 overexpressing breast cancer cell line. Therefore, this novel compound merits further development as an anti-breast cancer drug candidate.

Original languageEnglish
Pages (from-to)5816-5819
Number of pages4
JournalJournal of Medicinal Chemistry
Volume47
Issue number23
DOIs
Publication statusPublished - 2004 Nov 4

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Drug Discovery

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