Antitumor agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza

Xihong Wang; Kenneth F. Bastow; Chang Ming Sun; Yun Lian Lin; Hsi Jung Yu; Ming Jaw Don; Tian Shung Wu; Seikou Nakamura; Kuo Hsiung Lee

doi:10.1021/jm040112r

Antitumor agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza

Xihong Wang
, Kenneth F. Bastow
, Chang Ming Sun
, Yun Lian Lin
, Hsi Jung Yu
, Ming Jaw Don
, Tian Shung Wu
, Seikou Nakamura
, Kuo Hsiung Lee

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

217 Citations (Scopus)

Abstract

Neo-tanshinlactone (1) was isolated and synthesized for the first time and evaluated in vitro against several human cancer cell lines. Compound 1 showed significant inhibition against two ER+ human breast cancer cell lines and was 10-fold more potent and 20-fold more selective as compared to tamoxifen citrate. Compound 1 also potently inhibited an ER-, HER-2 overexpressing breast cancer cell line. Therefore, this novel compound merits further development as an anti-breast cancer drug candidate.

Original language	English
Pages (from-to)	5816-5819
Number of pages	4
Journal	Journal of Medicinal Chemistry
Volume	47
Issue number	23
DOIs	https://doi.org/10.1021/jm040112r
Publication status	Published - 2004 Nov 4

All Science Journal Classification (ASJC) codes

Molecular Medicine
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/jm040112r

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title = "Antitumor agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza",

abstract = "Neo-tanshinlactone (1) was isolated and synthesized for the first time and evaluated in vitro against several human cancer cell lines. Compound 1 showed significant inhibition against two ER+ human breast cancer cell lines and was 10-fold more potent and 20-fold more selective as compared to tamoxifen citrate. Compound 1 also potently inhibited an ER-, HER-2 overexpressing breast cancer cell line. Therefore, this novel compound merits further development as an anti-breast cancer drug candidate.",

author = "Xihong Wang and Bastow, \{Kenneth F.\} and Sun, \{Chang Ming\} and Lin, \{Yun Lian\} and Yu, \{Hsi Jung\} and Don, \{Ming Jaw\} and Wu, \{Tian Shung\} and Seikou Nakamura and Lee, \{Kuo Hsiung\}",

year = "2004",

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doi = "10.1021/jm040112r",

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AU - Wang, Xihong

AU - Bastow, Kenneth F.

AU - Sun, Chang Ming

AU - Lin, Yun Lian

AU - Yu, Hsi Jung

AU - Don, Ming Jaw

AU - Wu, Tian Shung

AU - Nakamura, Seikou

AU - Lee, Kuo Hsiung

PY - 2004/11/4

Y1 - 2004/11/4

N2 - Neo-tanshinlactone (1) was isolated and synthesized for the first time and evaluated in vitro against several human cancer cell lines. Compound 1 showed significant inhibition against two ER+ human breast cancer cell lines and was 10-fold more potent and 20-fold more selective as compared to tamoxifen citrate. Compound 1 also potently inhibited an ER-, HER-2 overexpressing breast cancer cell line. Therefore, this novel compound merits further development as an anti-breast cancer drug candidate.

AB - Neo-tanshinlactone (1) was isolated and synthesized for the first time and evaluated in vitro against several human cancer cell lines. Compound 1 showed significant inhibition against two ER+ human breast cancer cell lines and was 10-fold more potent and 20-fold more selective as compared to tamoxifen citrate. Compound 1 also potently inhibited an ER-, HER-2 overexpressing breast cancer cell line. Therefore, this novel compound merits further development as an anti-breast cancer drug candidate.

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IS - 23

ER -

Antitumor agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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