Apolipoprotein E polymorphism in various dementias in Taiwan Chinese population

H. M. Huang, Yu-Min Kuo, H. C. Ou, C. C. Lin, L. J. Chuo

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

To verify the association between APOE4 frequency and various dementias in Taiwan Chinese individuals, APOE genotypes were determined in patients with dementia of Alzheimer's type (AD), vascular dementia (VD), dementias due to other general medical conditions (OD), and dementia of Alzheimer's type with cerebral vascular disease (mixed type dementia; MD). Only AD patients exhibited higher APOE4 frequency (OR = 2.95, p = 0.001) than controls after Bonferroni correction to control the overall type I error rate for the multiple testing. No such difference was observed among VD, OD, MD and control groups. The lack of association between VD and APOE4 allele frequency suggests that APOE4 allele does not associate with cerebrovascular pathology related dementia in Taiwan Chinese.

Original languageEnglish
Pages (from-to)1415-1421
Number of pages7
JournalJournal of Neural Transmission
Volume109
Issue number11
DOIs
Publication statusPublished - 2002 Nov 1

Fingerprint

Apolipoproteins E
Taiwan
Vascular Dementia
Dementia
Population
Alzheimer Disease
Vascular Diseases
Gene Frequency
Alleles
Genotype
Pathology
Control Groups

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Huang, H. M. ; Kuo, Yu-Min ; Ou, H. C. ; Lin, C. C. ; Chuo, L. J. / Apolipoprotein E polymorphism in various dementias in Taiwan Chinese population. In: Journal of Neural Transmission. 2002 ; Vol. 109, No. 11. pp. 1415-1421.
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Apolipoprotein E polymorphism in various dementias in Taiwan Chinese population. / Huang, H. M.; Kuo, Yu-Min; Ou, H. C.; Lin, C. C.; Chuo, L. J.

In: Journal of Neural Transmission, Vol. 109, No. 11, 01.11.2002, p. 1415-1421.

Research output: Contribution to journalArticle

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