Apoptotic and nonapoptotic activities of pterostilbene against cancer

Rong Jane Chen, Hsiao Che Kuo, Li Hsin Cheng, Yu Hsuan Lee, Wen Tsan Chang, Bour Jr Wang, Ying Jan Wang, Hung Chi Cheng

Research output: Contribution to journalReview articlepeer-review

47 Citations (Scopus)


Cancer is a major cause of death. The outcomes of current therapeutic strategies against cancer often ironically lead to even increased mortality due to the subsequent drug resistance and to metastatic recurrence. Alternative medicines are thus urgently needed. Cumulative evidence has pointed out that pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene, PS) has excellent pharmacological benefits for the prevention and treatment for various types of cancer in their different stages of progression by evoking apoptotic or nonapoptotic anti-cancer activities. In this review article, we first update current knowledge regarding tumor progression toward accomplishment of metastasis. Subsequently, we review current literature regarding the anti-cancer activities of PS. Finally, we provide future perspectives to clinically utilize PS as novel cancer therapeutic remedies. We, therefore, conclude and propose that PS is one ideal alternative medicine to be administered in the diet as a nutritional supplement.

Original languageEnglish
Article number287
JournalInternational journal of molecular sciences
Issue number1
Publication statusPublished - 2018 Jan 18

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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