Apoptotic and nonapoptotic activities of pterostilbene against cancer

Rong-Jane Chen, Hsiao Che Kuo, Li Hsin Cheng, Yu-Hsuan Lee, Wen-Tsan Chang, Bour Jr Wang, Ying-Jan Wang, Hung-Chi Cheng

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Cancer is a major cause of death. The outcomes of current therapeutic strategies against cancer often ironically lead to even increased mortality due to the subsequent drug resistance and to metastatic recurrence. Alternative medicines are thus urgently needed. Cumulative evidence has pointed out that pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene, PS) has excellent pharmacological benefits for the prevention and treatment for various types of cancer in their different stages of progression by evoking apoptotic or nonapoptotic anti-cancer activities. In this review article, we first update current knowledge regarding tumor progression toward accomplishment of metastasis. Subsequently, we review current literature regarding the anti-cancer activities of PS. Finally, we provide future perspectives to clinically utilize PS as novel cancer therapeutic remedies. We, therefore, conclude and propose that PS is one ideal alternative medicine to be administered in the diet as a nutritional supplement.

Original languageEnglish
Article number287
JournalInternational journal of molecular sciences
Volume19
Issue number1
DOIs
Publication statusPublished - 2018 Jan 18

Fingerprint

Medicine
cancer
Nutrition
Tumors
Neoplasms
medicine
progressions
Complementary Therapies
Pharmaceutical Preparations
diets
mortality
supplements
metastasis
death
pterostilbene
Drug Resistance
drugs
tumors
Cause of Death
Therapeutics

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

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title = "Apoptotic and nonapoptotic activities of pterostilbene against cancer",
abstract = "Cancer is a major cause of death. The outcomes of current therapeutic strategies against cancer often ironically lead to even increased mortality due to the subsequent drug resistance and to metastatic recurrence. Alternative medicines are thus urgently needed. Cumulative evidence has pointed out that pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene, PS) has excellent pharmacological benefits for the prevention and treatment for various types of cancer in their different stages of progression by evoking apoptotic or nonapoptotic anti-cancer activities. In this review article, we first update current knowledge regarding tumor progression toward accomplishment of metastasis. Subsequently, we review current literature regarding the anti-cancer activities of PS. Finally, we provide future perspectives to clinically utilize PS as novel cancer therapeutic remedies. We, therefore, conclude and propose that PS is one ideal alternative medicine to be administered in the diet as a nutritional supplement.",
author = "Rong-Jane Chen and Kuo, {Hsiao Che} and Cheng, {Li Hsin} and Yu-Hsuan Lee and Wen-Tsan Chang and Wang, {Bour Jr} and Ying-Jan Wang and Hung-Chi Cheng",
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Apoptotic and nonapoptotic activities of pterostilbene against cancer. / Chen, Rong-Jane; Kuo, Hsiao Che; Cheng, Li Hsin; Lee, Yu-Hsuan; Chang, Wen-Tsan; Wang, Bour Jr; Wang, Ying-Jan; Cheng, Hung-Chi.

In: International journal of molecular sciences, Vol. 19, No. 1, 287, 18.01.2018.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Apoptotic and nonapoptotic activities of pterostilbene against cancer

AU - Chen, Rong-Jane

AU - Kuo, Hsiao Che

AU - Cheng, Li Hsin

AU - Lee, Yu-Hsuan

AU - Chang, Wen-Tsan

AU - Wang, Bour Jr

AU - Wang, Ying-Jan

AU - Cheng, Hung-Chi

PY - 2018/1/18

Y1 - 2018/1/18

N2 - Cancer is a major cause of death. The outcomes of current therapeutic strategies against cancer often ironically lead to even increased mortality due to the subsequent drug resistance and to metastatic recurrence. Alternative medicines are thus urgently needed. Cumulative evidence has pointed out that pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene, PS) has excellent pharmacological benefits for the prevention and treatment for various types of cancer in their different stages of progression by evoking apoptotic or nonapoptotic anti-cancer activities. In this review article, we first update current knowledge regarding tumor progression toward accomplishment of metastasis. Subsequently, we review current literature regarding the anti-cancer activities of PS. Finally, we provide future perspectives to clinically utilize PS as novel cancer therapeutic remedies. We, therefore, conclude and propose that PS is one ideal alternative medicine to be administered in the diet as a nutritional supplement.

AB - Cancer is a major cause of death. The outcomes of current therapeutic strategies against cancer often ironically lead to even increased mortality due to the subsequent drug resistance and to metastatic recurrence. Alternative medicines are thus urgently needed. Cumulative evidence has pointed out that pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene, PS) has excellent pharmacological benefits for the prevention and treatment for various types of cancer in their different stages of progression by evoking apoptotic or nonapoptotic anti-cancer activities. In this review article, we first update current knowledge regarding tumor progression toward accomplishment of metastasis. Subsequently, we review current literature regarding the anti-cancer activities of PS. Finally, we provide future perspectives to clinically utilize PS as novel cancer therapeutic remedies. We, therefore, conclude and propose that PS is one ideal alternative medicine to be administered in the diet as a nutritional supplement.

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