Apoptotic-related gene expression in oxaliplatin-treated CCM-1 colorectal adenocarcinoma and MALT-nt-1 mucosa-associated lymphoid tissue lymphoma cell lines

Guan Cheng Huang; Hsiao-Sheng Liu

doi:10.1016/j.gmbhs.2012.04.009

Apoptotic-related gene expression in oxaliplatin-treated CCM-1 colorectal adenocarcinoma and MALT-nt-1 mucosa-associated lymphoid tissue lymphoma cell lines

Guan Cheng Huang, Hsiao-Sheng Liu

Department of Microbiology and Immunology

Research output: Contribution to journal › Article

Abstract

The purpose of this study was to assess the apoptotic -related gene expression of single-agent oxaliplatin in vitro. Growth inhibition studies were performed using the human cerebral cavernous malformation-1 colorectal adenocarcinoma cell line and mucosa-associated lymphoid tissue-nt-1 lymphoma cell line. At 50% inhibitory concentrations, oxaliplatin displayed suppressive effects toward Bcl-2 and the surviving expression in human cancer cell lines, whereas the expression of Fas/FasL was completely abolished in peripheral blood cells. Our data showed that oxaliplatin exerts potent antiapoptotic effects in human normal peripheral blood mononuclear cells at the suprapharmacologic concentration, warranting further investigations in the role of autoimmune adverse events while being used in numerous cycles for the treatment of malignancies.

Original language	English
Pages (from-to)	41-42
Number of pages	2
Journal	Genomic Medicine, Biomarkers, and Health Sciences
Volume	4
Issue number	1-2
DOIs	https://doi.org/10.1016/j.gmbhs.2012.04.009
Publication status	Published - 2012 Mar 1

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)
Biomedical Engineering
Medicine(all)
Drug Discovery

Access to Document

10.1016/j.gmbhs.2012.04.009

Fingerprint Dive into the research topics of 'Apoptotic-related gene expression in oxaliplatin-treated CCM-1 colorectal adenocarcinoma and MALT-nt-1 mucosa-associated lymphoid tissue lymphoma cell lines'. Together they form a unique fingerprint.

Cite this

Huang, G. C., & Liu, H-S. (2012). Apoptotic-related gene expression in oxaliplatin-treated CCM-1 colorectal adenocarcinoma and MALT-nt-1 mucosa-associated lymphoid tissue lymphoma cell lines. Genomic Medicine, Biomarkers, and Health Sciences, 4(1-2), 41-42. https://doi.org/10.1016/j.gmbhs.2012.04.009

@article{52054f11c6ea44e6afa1955f0a588816,

title = "Apoptotic-related gene expression in oxaliplatin-treated CCM-1 colorectal adenocarcinoma and MALT-nt-1 mucosa-associated lymphoid tissue lymphoma cell lines",

abstract = "The purpose of this study was to assess the apoptotic -related gene expression of single-agent oxaliplatin in vitro. Growth inhibition studies were performed using the human cerebral cavernous malformation-1 colorectal adenocarcinoma cell line and mucosa-associated lymphoid tissue-nt-1 lymphoma cell line. At 50% inhibitory concentrations, oxaliplatin displayed suppressive effects toward Bcl-2 and the surviving expression in human cancer cell lines, whereas the expression of Fas/FasL was completely abolished in peripheral blood cells. Our data showed that oxaliplatin exerts potent antiapoptotic effects in human normal peripheral blood mononuclear cells at the suprapharmacologic concentration, warranting further investigations in the role of autoimmune adverse events while being used in numerous cycles for the treatment of malignancies.",

author = "Huang, {Guan Cheng} and Hsiao-Sheng Liu",

year = "2012",

month = mar,

day = "1",

doi = "10.1016/j.gmbhs.2012.04.009",

language = "English",

volume = "4",

pages = "41--42",

journal = "Genomic Medicine, Biomarkers, and Health Sciences",

issn = "2211-4254",

publisher = "Elsevier Taiwan LLC",

number = "1-2",

}

TY - JOUR

T1 - Apoptotic-related gene expression in oxaliplatin-treated CCM-1 colorectal adenocarcinoma and MALT-nt-1 mucosa-associated lymphoid tissue lymphoma cell lines

AU - Huang, Guan Cheng

AU - Liu, Hsiao-Sheng

PY - 2012/3/1

Y1 - 2012/3/1

N2 - The purpose of this study was to assess the apoptotic -related gene expression of single-agent oxaliplatin in vitro. Growth inhibition studies were performed using the human cerebral cavernous malformation-1 colorectal adenocarcinoma cell line and mucosa-associated lymphoid tissue-nt-1 lymphoma cell line. At 50% inhibitory concentrations, oxaliplatin displayed suppressive effects toward Bcl-2 and the surviving expression in human cancer cell lines, whereas the expression of Fas/FasL was completely abolished in peripheral blood cells. Our data showed that oxaliplatin exerts potent antiapoptotic effects in human normal peripheral blood mononuclear cells at the suprapharmacologic concentration, warranting further investigations in the role of autoimmune adverse events while being used in numerous cycles for the treatment of malignancies.

AB - The purpose of this study was to assess the apoptotic -related gene expression of single-agent oxaliplatin in vitro. Growth inhibition studies were performed using the human cerebral cavernous malformation-1 colorectal adenocarcinoma cell line and mucosa-associated lymphoid tissue-nt-1 lymphoma cell line. At 50% inhibitory concentrations, oxaliplatin displayed suppressive effects toward Bcl-2 and the surviving expression in human cancer cell lines, whereas the expression of Fas/FasL was completely abolished in peripheral blood cells. Our data showed that oxaliplatin exerts potent antiapoptotic effects in human normal peripheral blood mononuclear cells at the suprapharmacologic concentration, warranting further investigations in the role of autoimmune adverse events while being used in numerous cycles for the treatment of malignancies.

UR - http://www.scopus.com/inward/record.url?scp=84861576909&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861576909&partnerID=8YFLogxK

U2 - 10.1016/j.gmbhs.2012.04.009

DO - 10.1016/j.gmbhs.2012.04.009

M3 - Article

AN - SCOPUS:84861576909

VL - 4

SP - 41

EP - 42

JO - Genomic Medicine, Biomarkers, and Health Sciences

JF - Genomic Medicine, Biomarkers, and Health Sciences

SN - 2211-4254

IS - 1-2

ER -