Abstract
The purpose of this study was to assess the apoptotic -related gene expression of single-agent oxaliplatin in vitro. Growth inhibition studies were performed using the human cerebral cavernous malformation-1 colorectal adenocarcinoma cell line and mucosa-associated lymphoid tissue-nt-1 lymphoma cell line. At 50% inhibitory concentrations, oxaliplatin displayed suppressive effects toward Bcl-2 and the surviving expression in human cancer cell lines, whereas the expression of Fas/FasL was completely abolished in peripheral blood cells. Our data showed that oxaliplatin exerts potent antiapoptotic effects in human normal peripheral blood mononuclear cells at the suprapharmacologic concentration, warranting further investigations in the role of autoimmune adverse events while being used in numerous cycles for the treatment of malignancies.
| Original language | English |
|---|---|
| Pages (from-to) | 41-42 |
| Number of pages | 2 |
| Journal | Genomic Medicine, Biomarkers, and Health Sciences |
| Volume | 4 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 2012 Mar 1 |
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All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- Biomedical Engineering
- Medicine(all)
- Drug Discovery
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Apoptotic-related gene expression in oxaliplatin-treated CCM-1 colorectal adenocarcinoma and MALT-nt-1 mucosa-associated lymphoid tissue lymphoma cell lines. / Huang, Guan Cheng; Liu, Hsiao-Sheng.
In: Genomic Medicine, Biomarkers, and Health Sciences, Vol. 4, No. 1-2, 01.03.2012, p. 41-42.Research output: Contribution to journal › Article
TY - JOUR
T1 - Apoptotic-related gene expression in oxaliplatin-treated CCM-1 colorectal adenocarcinoma and MALT-nt-1 mucosa-associated lymphoid tissue lymphoma cell lines
AU - Huang, Guan Cheng
AU - Liu, Hsiao-Sheng
PY - 2012/3/1
Y1 - 2012/3/1
N2 - The purpose of this study was to assess the apoptotic -related gene expression of single-agent oxaliplatin in vitro. Growth inhibition studies were performed using the human cerebral cavernous malformation-1 colorectal adenocarcinoma cell line and mucosa-associated lymphoid tissue-nt-1 lymphoma cell line. At 50% inhibitory concentrations, oxaliplatin displayed suppressive effects toward Bcl-2 and the surviving expression in human cancer cell lines, whereas the expression of Fas/FasL was completely abolished in peripheral blood cells. Our data showed that oxaliplatin exerts potent antiapoptotic effects in human normal peripheral blood mononuclear cells at the suprapharmacologic concentration, warranting further investigations in the role of autoimmune adverse events while being used in numerous cycles for the treatment of malignancies.
AB - The purpose of this study was to assess the apoptotic -related gene expression of single-agent oxaliplatin in vitro. Growth inhibition studies were performed using the human cerebral cavernous malformation-1 colorectal adenocarcinoma cell line and mucosa-associated lymphoid tissue-nt-1 lymphoma cell line. At 50% inhibitory concentrations, oxaliplatin displayed suppressive effects toward Bcl-2 and the surviving expression in human cancer cell lines, whereas the expression of Fas/FasL was completely abolished in peripheral blood cells. Our data showed that oxaliplatin exerts potent antiapoptotic effects in human normal peripheral blood mononuclear cells at the suprapharmacologic concentration, warranting further investigations in the role of autoimmune adverse events while being used in numerous cycles for the treatment of malignancies.
UR - http://www.scopus.com/inward/record.url?scp=84861576909&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84861576909&partnerID=8YFLogxK
U2 - 10.1016/j.gmbhs.2012.04.009
DO - 10.1016/j.gmbhs.2012.04.009
M3 - Article
AN - SCOPUS:84861576909
VL - 4
SP - 41
EP - 42
JO - Genomic Medicine, Biomarkers, and Health Sciences
JF - Genomic Medicine, Biomarkers, and Health Sciences
SN - 2211-4254
IS - 1-2
ER -