Appearance of intratypic recombination of enterovirus 71 in Taiwan from 2002 to 2005

Shih Chen Huang; Yun Wei Hsu; Hsuan Chen Wang; Sheng Wen Huang; David Kiang; Huey Pin Tsai; Shih Ming Wang; Ching Chuan Liu; Kui Hsiang Lin; Ih Jen Su; Jen Ren Wang

doi:10.1016/j.virusres.2007.10.002

Appearance of intratypic recombination of enterovirus 71 in Taiwan from 2002 to 2005

Shih Chen Huang, Yun Wei Hsu, Hsuan Chen Wang, Sheng Wen Huang, David Kiang, Huey Pin Tsai, Shih Ming Wang, Ching Chuan Liu, Kui Hsiang Lin, Ih Jen Su, Jen Ren Wang

Research output: Contribution to journal › Article › peer-review

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Abstract

Genetic recombination is a well-known phenomenon for enteroviruses. In this study, we determined the phylogenetic relationships of five distinct regions of the EV71 genome for 73 EV71 isolates from 1986 and from 1998 to 2005 in Taiwan. Phylogenetic analyses showed that the 5′-UTR, VP4-VP2, VP1, and 3D regions of EV71 isolated in 2004 and 2005 were grouped into genotype C. However, the 2B region of these isolates differed in that it grouped with genotype B, indicating recombination within EV71 had occurred. This intratypic recombination was first seen in 2002 and became predominant in 2004 and 2005. The simplot and bootscan analyses identified two recombination points located at the 3′-termini of the 2A and 3C regions. This intratypic recombination was identified among naturally circulating EV71 isolates in Taiwan, therefore, it suggests that nonstructural genes may recombine to produce new EV71 variants.

Original language	English
Pages (from-to)	250-259
Number of pages	10
Journal	Virus Research
Volume	131
Issue number	2
DOIs	https://doi.org/10.1016/j.virusres.2007.10.002
Publication status	Published - 2008 Feb

All Science Journal Classification (ASJC) codes

Virology
Infectious Diseases
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.virusres.2007.10.002

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title = "Appearance of intratypic recombination of enterovirus 71 in Taiwan from 2002 to 2005",

abstract = "Genetic recombination is a well-known phenomenon for enteroviruses. In this study, we determined the phylogenetic relationships of five distinct regions of the EV71 genome for 73 EV71 isolates from 1986 and from 1998 to 2005 in Taiwan. Phylogenetic analyses showed that the 5′-UTR, VP4-VP2, VP1, and 3D regions of EV71 isolated in 2004 and 2005 were grouped into genotype C. However, the 2B region of these isolates differed in that it grouped with genotype B, indicating recombination within EV71 had occurred. This intratypic recombination was first seen in 2002 and became predominant in 2004 and 2005. The simplot and bootscan analyses identified two recombination points located at the 3′-termini of the 2A and 3C regions. This intratypic recombination was identified among naturally circulating EV71 isolates in Taiwan, therefore, it suggests that nonstructural genes may recombine to produce new EV71 variants.",

author = "Huang, {Shih Chen} and Hsu, {Yun Wei} and Wang, {Hsuan Chen} and Huang, {Sheng Wen} and David Kiang and Tsai, {Huey Pin} and Wang, {Shih Ming} and Liu, {Ching Chuan} and Lin, {Kui Hsiang} and Su, {Ih Jen} and Wang, {Jen Ren}",

note = "Funding Information: The authors wish to thank the members of Virology Laboratory at National Cheng Kung University Hospital for isolation of EV71 for this study. This study was supported by National Health Research Institutes grants; National Science Council grant NSC 95-3112-B-006; and by Department of Health, Taiwan Centers for Disease Control grant CDC94-RM-012.",

year = "2008",

month = feb,

doi = "10.1016/j.virusres.2007.10.002",

language = "English",

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AU - Huang, Shih Chen

AU - Hsu, Yun Wei

AU - Wang, Hsuan Chen

AU - Huang, Sheng Wen

AU - Kiang, David

AU - Tsai, Huey Pin

AU - Wang, Shih Ming

AU - Liu, Ching Chuan

AU - Lin, Kui Hsiang

AU - Su, Ih Jen

AU - Wang, Jen Ren

N1 - Funding Information: The authors wish to thank the members of Virology Laboratory at National Cheng Kung University Hospital for isolation of EV71 for this study. This study was supported by National Health Research Institutes grants; National Science Council grant NSC 95-3112-B-006; and by Department of Health, Taiwan Centers for Disease Control grant CDC94-RM-012.

PY - 2008/2

Y1 - 2008/2

N2 - Genetic recombination is a well-known phenomenon for enteroviruses. In this study, we determined the phylogenetic relationships of five distinct regions of the EV71 genome for 73 EV71 isolates from 1986 and from 1998 to 2005 in Taiwan. Phylogenetic analyses showed that the 5′-UTR, VP4-VP2, VP1, and 3D regions of EV71 isolated in 2004 and 2005 were grouped into genotype C. However, the 2B region of these isolates differed in that it grouped with genotype B, indicating recombination within EV71 had occurred. This intratypic recombination was first seen in 2002 and became predominant in 2004 and 2005. The simplot and bootscan analyses identified two recombination points located at the 3′-termini of the 2A and 3C regions. This intratypic recombination was identified among naturally circulating EV71 isolates in Taiwan, therefore, it suggests that nonstructural genes may recombine to produce new EV71 variants.

AB - Genetic recombination is a well-known phenomenon for enteroviruses. In this study, we determined the phylogenetic relationships of five distinct regions of the EV71 genome for 73 EV71 isolates from 1986 and from 1998 to 2005 in Taiwan. Phylogenetic analyses showed that the 5′-UTR, VP4-VP2, VP1, and 3D regions of EV71 isolated in 2004 and 2005 were grouped into genotype C. However, the 2B region of these isolates differed in that it grouped with genotype B, indicating recombination within EV71 had occurred. This intratypic recombination was first seen in 2002 and became predominant in 2004 and 2005. The simplot and bootscan analyses identified two recombination points located at the 3′-termini of the 2A and 3C regions. This intratypic recombination was identified among naturally circulating EV71 isolates in Taiwan, therefore, it suggests that nonstructural genes may recombine to produce new EV71 variants.

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Appearance of intratypic recombination of enterovirus 71 in Taiwan from 2002 to 2005

Abstract

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