TY - JOUR
T1 - Applicability of staging systems for patients with hepatocellular carcinoma is dependent on treatment method - Analysis of 2010 Taiwanese patients
AU - Chen, Chien Hung
AU - Hu, Fu Chang
AU - Huang, Guan Tarn
AU - Lee, Po Huang
AU - Tsang, Yuk Ming
AU - Cheng, Ann Lii
AU - Chen, Ding Shinn
AU - Wang, Jung Der
AU - Sheu, Jin Chuan
PY - 2009/6
Y1 - 2009/6
N2 - The aim of this study was to compare six prognostic staging systems (Okuda stage, TNM stage, CLIP score, BCLC stage, JIS score and Tokyo score) in predicting survival in patients with hepatocellular carcinoma (HCC). A total of 2010 Taiwanese HCC patients were included. Demographic, laboratory and tumour characteristics were determined at diagnosis. Predictors of survival included serum levels of albumin, total bilirubin, alkaline phosphatase, α-fetoprotein, ascites, tumour size and portal vein invasion. The Tokyo score was the most informative one for predicting the survival of HCC patients as a whole, receiving surgical resection, or receiving transarterial chemoembolisation. CLIP score was the best fit system for HCC patients receiving chemotherapy or supportive care. Each staging system showed a significant difference in predicting the probability of survival across different stages. The applicability of staging systems for patients with HCC was dependent on treatment methods.
AB - The aim of this study was to compare six prognostic staging systems (Okuda stage, TNM stage, CLIP score, BCLC stage, JIS score and Tokyo score) in predicting survival in patients with hepatocellular carcinoma (HCC). A total of 2010 Taiwanese HCC patients were included. Demographic, laboratory and tumour characteristics were determined at diagnosis. Predictors of survival included serum levels of albumin, total bilirubin, alkaline phosphatase, α-fetoprotein, ascites, tumour size and portal vein invasion. The Tokyo score was the most informative one for predicting the survival of HCC patients as a whole, receiving surgical resection, or receiving transarterial chemoembolisation. CLIP score was the best fit system for HCC patients receiving chemotherapy or supportive care. Each staging system showed a significant difference in predicting the probability of survival across different stages. The applicability of staging systems for patients with HCC was dependent on treatment methods.
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U2 - 10.1016/j.ejca.2008.12.025
DO - 10.1016/j.ejca.2008.12.025
M3 - Article
C2 - 19157858
AN - SCOPUS:67349206740
SN - 0959-8049
VL - 45
SP - 1630
EP - 1639
JO - European Journal of Cancer
JF - European Journal of Cancer
IS - 9
ER -