Applicability of staging systems for patients with hepatocellular carcinoma is dependent on treatment method - Analysis of 2010 Taiwanese patients

Chien Hung Chen, Fu Chang Hu, Guan Tarn Huang, Po Huang Lee, Yuk Ming Tsang, Ann Lii Cheng, Ding Shinn Chen, Jung Der Wang, Jin Chuan Sheu

Research output: Contribution to journalArticlepeer-review

64 Citations (Scopus)

Abstract

The aim of this study was to compare six prognostic staging systems (Okuda stage, TNM stage, CLIP score, BCLC stage, JIS score and Tokyo score) in predicting survival in patients with hepatocellular carcinoma (HCC). A total of 2010 Taiwanese HCC patients were included. Demographic, laboratory and tumour characteristics were determined at diagnosis. Predictors of survival included serum levels of albumin, total bilirubin, alkaline phosphatase, α-fetoprotein, ascites, tumour size and portal vein invasion. The Tokyo score was the most informative one for predicting the survival of HCC patients as a whole, receiving surgical resection, or receiving transarterial chemoembolisation. CLIP score was the best fit system for HCC patients receiving chemotherapy or supportive care. Each staging system showed a significant difference in predicting the probability of survival across different stages. The applicability of staging systems for patients with HCC was dependent on treatment methods.

Original languageEnglish
Pages (from-to)1630-1639
Number of pages10
JournalEuropean Journal of Cancer
Volume45
Issue number9
DOIs
Publication statusPublished - 2009 Jun 1

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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