Application of genetic risk score for in-stent restenosis of second- and third-generation drug-eluting stents in geriatric patients

Yu Ling Hsu, Mu Shiang Huang, Hsien Yuan Chang, Cheng Han Lee, Dao Peng Chen, Yi Heng Li, Ting Hsin Chao, Yen Wen Liu, Ping Yen Liu

Research output: Contribution to journalArticlepeer-review


Background: The second-and third-generation drug-eluting stents (DESs) in-stent restenosis (ISR) genetic risk score (GRS) model has been previously validated. However, the model has not been validated in geriatric patients. Therefore, we conducted this study to test the feasibility of the DES-ISR GRS model in geriatric patients with coronary artery disease (CAD) in Taiwan. Methods: We conducted a retrospective, single-center cohort study and included geriatric patients (age ≥ 65 years) with CAD and second-or third-generation DES(s) deployment. Patients undergoing maintenance dialysis were excluded. ISR was defined as ≥ 50% luminal narrowing on the follow-up coronary arteriography. The DES-ISR GRS model included five selected exonic single-nucleotide polymorphisms (SNPs): CAMLG, GALNT2, C11orf84, THOC5, and SAMD11. The GRS was defined as the sum of the five selected SNPs for the risk allele. Results: We enrolled 298 geriatric patients from January 2010 and December 2019 in this study. After propensity score matching, there were 192 geriatric patients with CAD in the final analysis, of which 32 patients had ISR. Patients were divided into two groups based on their GRS values: low (0–2) and high (≥ 3) GRS. A high GRS was significantly associated with DES-ISR in geriatric patients. Conclusion: Those geriatric patients with a high GRS had significantly higher second-or third-generation DES ISR rates. The five SNP-derived DES-ISR GRS model could provide genetic information for interventional cardiologists to treat geriatric patients with CAD. Trial registration: The primary study protocol was registered with with registration number: NCT03877614; on March 15, 2019. ( ).

Original languageEnglish
Article number443
JournalBMC geriatrics
Issue number1
Publication statusPublished - 2023 Dec

All Science Journal Classification (ASJC) codes

  • Geriatrics and Gerontology


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