Application of gold nanoparticles for enhanced photo-thermal therapy of urothelial carcinoma

Y. J. Wu, Chih-Hung Chen, H. S.W. Chang, W. C. Chen, Jia-Jin Chen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

The aim of this study is to utilize photothermal therapy (PTT) to treat urothelial cancer using the unique optical properties- surface plasmon resonance of gold nanoparticles (GNPs). The GNPs were conjugated with anti-EGFR and anti- MUC7 antibody for tumor targeting. The conjugated GNPs were exposed under a green light laser (532nm) to produce the enough thermal energy and to kill the transitional cell carcinomas (TCC). Our results show that the cancer cells (MBT2, T24, 9202, 8301) were damaged at relatively lower energy (10 W/cm 2, 1.6 Hz with 300 ms) compared with the group without added GNPs. The damage was directly related to the applied laser energy and irradiation time. The therapeutic effects of superficial disease in situ by intravesical GNP agents instillation will be further performed in animal study of C3H mice. It is expected that the mini-invasive technology of PPT with GNPs not only reduces the high recurrence of TCC but also avoids the side effects from traditional chemotherapy.

Original languageEnglish
Title of host publication5th Kuala Lumpur International Conference on Biomedical Engineering 2011, BIOMED 2011
Pages380-383
Number of pages4
DOIs
Publication statusPublished - 2011 Jul 11
Event5th Kuala Lumpur International Conference on Biomedical Engineering, BIOMED 2011, Held in Conjunction with the 8th Asian Pacific Conference on Medical and Biological Engineering, APCMBE 2011 - Kuala Lumpur, Malaysia
Duration: 2011 Jun 202011 Jun 23

Publication series

NameIFMBE Proceedings
Volume35 IFMBE
ISSN (Print)1680-0737

Other

Other5th Kuala Lumpur International Conference on Biomedical Engineering, BIOMED 2011, Held in Conjunction with the 8th Asian Pacific Conference on Medical and Biological Engineering, APCMBE 2011
CountryMalaysia
CityKuala Lumpur
Period11-06-2011-06-23

Fingerprint

Gold
Nanoparticles
Cells
Neoplasm Antibodies
Methyl Green
Chemotherapy
Lasers
Surface plasmon resonance
Thermal energy
Antibodies
Hot Temperature
Tumors
Animals
Optical properties
Irradiation

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomedical Engineering

Cite this

Wu, Y. J., Chen, C-H., Chang, H. S. W., Chen, W. C., & Chen, J-J. (2011). Application of gold nanoparticles for enhanced photo-thermal therapy of urothelial carcinoma. In 5th Kuala Lumpur International Conference on Biomedical Engineering 2011, BIOMED 2011 (pp. 380-383). (IFMBE Proceedings; Vol. 35 IFMBE). https://doi.org/10.1007/978-3-642-21729-6_98
Wu, Y. J. ; Chen, Chih-Hung ; Chang, H. S.W. ; Chen, W. C. ; Chen, Jia-Jin. / Application of gold nanoparticles for enhanced photo-thermal therapy of urothelial carcinoma. 5th Kuala Lumpur International Conference on Biomedical Engineering 2011, BIOMED 2011. 2011. pp. 380-383 (IFMBE Proceedings).
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abstract = "The aim of this study is to utilize photothermal therapy (PTT) to treat urothelial cancer using the unique optical properties- surface plasmon resonance of gold nanoparticles (GNPs). The GNPs were conjugated with anti-EGFR and anti- MUC7 antibody for tumor targeting. The conjugated GNPs were exposed under a green light laser (532nm) to produce the enough thermal energy and to kill the transitional cell carcinomas (TCC). Our results show that the cancer cells (MBT2, T24, 9202, 8301) were damaged at relatively lower energy (10 W/cm 2, 1.6 Hz with 300 ms) compared with the group without added GNPs. The damage was directly related to the applied laser energy and irradiation time. The therapeutic effects of superficial disease in situ by intravesical GNP agents instillation will be further performed in animal study of C3H mice. It is expected that the mini-invasive technology of PPT with GNPs not only reduces the high recurrence of TCC but also avoids the side effects from traditional chemotherapy.",
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Wu, YJ, Chen, C-H, Chang, HSW, Chen, WC & Chen, J-J 2011, Application of gold nanoparticles for enhanced photo-thermal therapy of urothelial carcinoma. in 5th Kuala Lumpur International Conference on Biomedical Engineering 2011, BIOMED 2011. IFMBE Proceedings, vol. 35 IFMBE, pp. 380-383, 5th Kuala Lumpur International Conference on Biomedical Engineering, BIOMED 2011, Held in Conjunction with the 8th Asian Pacific Conference on Medical and Biological Engineering, APCMBE 2011, Kuala Lumpur, Malaysia, 11-06-20. https://doi.org/10.1007/978-3-642-21729-6_98

Application of gold nanoparticles for enhanced photo-thermal therapy of urothelial carcinoma. / Wu, Y. J.; Chen, Chih-Hung; Chang, H. S.W.; Chen, W. C.; Chen, Jia-Jin.

5th Kuala Lumpur International Conference on Biomedical Engineering 2011, BIOMED 2011. 2011. p. 380-383 (IFMBE Proceedings; Vol. 35 IFMBE).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AB - The aim of this study is to utilize photothermal therapy (PTT) to treat urothelial cancer using the unique optical properties- surface plasmon resonance of gold nanoparticles (GNPs). The GNPs were conjugated with anti-EGFR and anti- MUC7 antibody for tumor targeting. The conjugated GNPs were exposed under a green light laser (532nm) to produce the enough thermal energy and to kill the transitional cell carcinomas (TCC). Our results show that the cancer cells (MBT2, T24, 9202, 8301) were damaged at relatively lower energy (10 W/cm 2, 1.6 Hz with 300 ms) compared with the group without added GNPs. The damage was directly related to the applied laser energy and irradiation time. The therapeutic effects of superficial disease in situ by intravesical GNP agents instillation will be further performed in animal study of C3H mice. It is expected that the mini-invasive technology of PPT with GNPs not only reduces the high recurrence of TCC but also avoids the side effects from traditional chemotherapy.

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Wu YJ, Chen C-H, Chang HSW, Chen WC, Chen J-J. Application of gold nanoparticles for enhanced photo-thermal therapy of urothelial carcinoma. In 5th Kuala Lumpur International Conference on Biomedical Engineering 2011, BIOMED 2011. 2011. p. 380-383. (IFMBE Proceedings). https://doi.org/10.1007/978-3-642-21729-6_98