Application of implantable wireless biomicrosystem for monitoring electrode-nerve impedance of animal after sciatic nerve injury

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

In neural prosthetic applications, it is imperative to monitor the impedance of implantable cuff electrode for the effective sensing and stimulating schemes. With the development of an implantable biomicrosystem, this study was conducted to monitor the time-course changes of electrode-nerve impedance as well as to elicit constant stimulation current for aiding nerve repair in an experimental sciatic nerve injury animal model. For continuous in vivo impedance monitoring, a transcutaneous magnetic coupling technique was adopted for transmitting power and command into the internal module and sending outwards the impedance measurement. The two-terminal and four-terminal methods were adopted for measuring the electrode-tissue interfacing impedance and tissue impedance. To avoid high sampling rate required, a gain-phase detector was utilized for direct output of the magnitude and phase shift of the impedance measurement. Validation tests of impedance measurement and microstimulation function were first performed in an in-vitro impedance model. The differences of measured impedance were less than 10 % in comparison with those measured by precision LCR meter. A self-sizing spiral cuff electrode was fabricated and wrapped around the injured sciatic nerve of New Zealand rabbit for monitoring the changes of electrode-nerve impedance when the animal was awake but partly constrained in a restrainer. In addition, commands for varied level of constant current can be delivered via the magnetic coupling in an attempt to assist the nerve repair.

Original languageEnglish
Title of host publication2008 IEEE International Symposium on Circuits and Systems, ISCAS 2008
Pages1112-1115
Number of pages4
DOIs
Publication statusPublished - 2008
Event2008 IEEE International Symposium on Circuits and Systems, ISCAS 2008 - Seattle, WA, United States
Duration: 2008 May 182008 May 21

Other

Other2008 IEEE International Symposium on Circuits and Systems, ISCAS 2008
CountryUnited States
CitySeattle, WA
Period08-05-1808-05-21

Fingerprint

Animals
Electrodes
Monitoring
Magnetic couplings
Repair
Tissue
Prosthetics
Phase shift
Sampling
Detectors

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Electrical and Electronic Engineering

Cite this

@inproceedings{eb177653624d48008b2902fbbb2a71bb,
title = "Application of implantable wireless biomicrosystem for monitoring electrode-nerve impedance of animal after sciatic nerve injury",
abstract = "In neural prosthetic applications, it is imperative to monitor the impedance of implantable cuff electrode for the effective sensing and stimulating schemes. With the development of an implantable biomicrosystem, this study was conducted to monitor the time-course changes of electrode-nerve impedance as well as to elicit constant stimulation current for aiding nerve repair in an experimental sciatic nerve injury animal model. For continuous in vivo impedance monitoring, a transcutaneous magnetic coupling technique was adopted for transmitting power and command into the internal module and sending outwards the impedance measurement. The two-terminal and four-terminal methods were adopted for measuring the electrode-tissue interfacing impedance and tissue impedance. To avoid high sampling rate required, a gain-phase detector was utilized for direct output of the magnitude and phase shift of the impedance measurement. Validation tests of impedance measurement and microstimulation function were first performed in an in-vitro impedance model. The differences of measured impedance were less than 10 {\%} in comparison with those measured by precision LCR meter. A self-sizing spiral cuff electrode was fabricated and wrapped around the injured sciatic nerve of New Zealand rabbit for monitoring the changes of electrode-nerve impedance when the animal was awake but partly constrained in a restrainer. In addition, commands for varied level of constant current can be delivered via the magnetic coupling in an attempt to assist the nerve repair.",
author = "Li, {Yu Ting} and Jia-Jin Chen and Chou-Ching Lin",
year = "2008",
doi = "10.1109/ISCAS.2008.4541617",
language = "English",
isbn = "9781424416844",
pages = "1112--1115",
booktitle = "2008 IEEE International Symposium on Circuits and Systems, ISCAS 2008",

}

Li, YT, Chen, J-J & Lin, C-C 2008, Application of implantable wireless biomicrosystem for monitoring electrode-nerve impedance of animal after sciatic nerve injury. in 2008 IEEE International Symposium on Circuits and Systems, ISCAS 2008., 4541617, pp. 1112-1115, 2008 IEEE International Symposium on Circuits and Systems, ISCAS 2008, Seattle, WA, United States, 08-05-18. https://doi.org/10.1109/ISCAS.2008.4541617

Application of implantable wireless biomicrosystem for monitoring electrode-nerve impedance of animal after sciatic nerve injury. / Li, Yu Ting; Chen, Jia-Jin; Lin, Chou-Ching.

2008 IEEE International Symposium on Circuits and Systems, ISCAS 2008. 2008. p. 1112-1115 4541617.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

TY - GEN

T1 - Application of implantable wireless biomicrosystem for monitoring electrode-nerve impedance of animal after sciatic nerve injury

AU - Li, Yu Ting

AU - Chen, Jia-Jin

AU - Lin, Chou-Ching

PY - 2008

Y1 - 2008

N2 - In neural prosthetic applications, it is imperative to monitor the impedance of implantable cuff electrode for the effective sensing and stimulating schemes. With the development of an implantable biomicrosystem, this study was conducted to monitor the time-course changes of electrode-nerve impedance as well as to elicit constant stimulation current for aiding nerve repair in an experimental sciatic nerve injury animal model. For continuous in vivo impedance monitoring, a transcutaneous magnetic coupling technique was adopted for transmitting power and command into the internal module and sending outwards the impedance measurement. The two-terminal and four-terminal methods were adopted for measuring the electrode-tissue interfacing impedance and tissue impedance. To avoid high sampling rate required, a gain-phase detector was utilized for direct output of the magnitude and phase shift of the impedance measurement. Validation tests of impedance measurement and microstimulation function were first performed in an in-vitro impedance model. The differences of measured impedance were less than 10 % in comparison with those measured by precision LCR meter. A self-sizing spiral cuff electrode was fabricated and wrapped around the injured sciatic nerve of New Zealand rabbit for monitoring the changes of electrode-nerve impedance when the animal was awake but partly constrained in a restrainer. In addition, commands for varied level of constant current can be delivered via the magnetic coupling in an attempt to assist the nerve repair.

AB - In neural prosthetic applications, it is imperative to monitor the impedance of implantable cuff electrode for the effective sensing and stimulating schemes. With the development of an implantable biomicrosystem, this study was conducted to monitor the time-course changes of electrode-nerve impedance as well as to elicit constant stimulation current for aiding nerve repair in an experimental sciatic nerve injury animal model. For continuous in vivo impedance monitoring, a transcutaneous magnetic coupling technique was adopted for transmitting power and command into the internal module and sending outwards the impedance measurement. The two-terminal and four-terminal methods were adopted for measuring the electrode-tissue interfacing impedance and tissue impedance. To avoid high sampling rate required, a gain-phase detector was utilized for direct output of the magnitude and phase shift of the impedance measurement. Validation tests of impedance measurement and microstimulation function were first performed in an in-vitro impedance model. The differences of measured impedance were less than 10 % in comparison with those measured by precision LCR meter. A self-sizing spiral cuff electrode was fabricated and wrapped around the injured sciatic nerve of New Zealand rabbit for monitoring the changes of electrode-nerve impedance when the animal was awake but partly constrained in a restrainer. In addition, commands for varied level of constant current can be delivered via the magnetic coupling in an attempt to assist the nerve repair.

UR - http://www.scopus.com/inward/record.url?scp=51749110452&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=51749110452&partnerID=8YFLogxK

U2 - 10.1109/ISCAS.2008.4541617

DO - 10.1109/ISCAS.2008.4541617

M3 - Conference contribution

SN - 9781424416844

SP - 1112

EP - 1115

BT - 2008 IEEE International Symposium on Circuits and Systems, ISCAS 2008

ER -