TY - JOUR
T1 - Application of MEMS technology and engineering in medicine
T2 - A new paradigm for facial muscle reanimation
AU - Cockerham, Kimberly
AU - Aro, Seppo
AU - Liu, Wentai
AU - Pantchenko, Oxana
AU - Olmos, Andrea
AU - Oehlberg, Mark
AU - Sivaprakasam, Mohansankar
AU - Crow, Lauren
PY - 2008
Y1 - 2008
N2 - Translational research may lead to development of micro-electromechanical system-based devices to treat muscle and nerve dysfunctions whose current treatments are inadequate and, at best, palliative. This paper discusses the development of engineered microsystems as a treatment option for palsies of the seventh cranial nerve and the potential application of these devices as a platform technology for treatment of other nervous dysfunctions. The engineering techniques for electrical and chemical stimulation of denervated muscle are discussed along with current caveats from clinical and engineering standpoints. As opposed to current treatments, miniaturized implants offer the possibility of the reduced toxicity and increased specificity of direct drug delivery. As with the increased miniaturization of other technologies, engineering of these increasingly small implantable microsystems holds great promise for the future development of yet smaller, even nanoscale, implantable devices.
AB - Translational research may lead to development of micro-electromechanical system-based devices to treat muscle and nerve dysfunctions whose current treatments are inadequate and, at best, palliative. This paper discusses the development of engineered microsystems as a treatment option for palsies of the seventh cranial nerve and the potential application of these devices as a platform technology for treatment of other nervous dysfunctions. The engineering techniques for electrical and chemical stimulation of denervated muscle are discussed along with current caveats from clinical and engineering standpoints. As opposed to current treatments, miniaturized implants offer the possibility of the reduced toxicity and increased specificity of direct drug delivery. As with the increased miniaturization of other technologies, engineering of these increasingly small implantable microsystems holds great promise for the future development of yet smaller, even nanoscale, implantable devices.
UR - http://www.scopus.com/inward/record.url?scp=48649097125&partnerID=8YFLogxK
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U2 - 10.1586/17434440.5.3.371
DO - 10.1586/17434440.5.3.371
M3 - Review article
C2 - 18452387
AN - SCOPUS:48649097125
SN - 1743-4440
VL - 5
SP - 371
EP - 381
JO - Expert Review of Medical Devices
JF - Expert Review of Medical Devices
IS - 3
ER -