Application of nonionic surfactants combining hydrophobic and hydrophilic cholelitholytic solvents on dissolution of gallstones

Mei Yeut Lim, Tse Chuan Chou, Xi Zhang Lin, Chiung Yu Chen, Tzong Rong Ling, Shu Chu Shiesh

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Application of nonionic surfactants in chemolitholysis was developed to combine two immiscible cholelitholytic solvents, MTBE and EDTA, into a homogeneous solution to increase the efficiency of gallstone dissolution. Eight kinds of Sinopol were employed to investigate and prepare the homogeneous solution, which included MTBE, EDTA (2wt.%) aqueous solution and the Sinopol, thereby, an in vitro study of chemolitholysis was carried out. Three kinds of gallstones were characterized by FTIR and SEM. The dissolution percentage of three kinds of gallstones in the homogeneous (Sinopol mixed) solution was evaluated and a comparison of the average dissolution percentage between these Sinopol mixed solutions and traditional cholelitholytic solvents was made. The composition of gallstones was classified into oil-soluble and water-soluble groups. Furthermore, the hydrophobic and hydrophilic properties of solvents corresponding to oil-soluble and water-soluble gallstone components were analysed and discussed with a phase diagram. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)265-274
Number of pages10
JournalColloids and Surfaces B: Biointerfaces
Issue number4
Publication statusPublished - 2000 Apr 15


All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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