TY - JOUR
T1 - Application of nonionic surfactants combining hydrophobic and hydrophilic cholelitholytic solvents on dissolution of gallstones
AU - Lim, Mei Yeut
AU - Chou, Tse Chuan
AU - Lin, Xi Zhang
AU - Chen, Chiung Yu
AU - Ling, Tzong Rong
AU - Shiesh, Shu Chu
N1 - Funding Information:
The authors would like to thank Miss Huai-Jane Tsao for her assistance in this study. This study was supported by grants NCS 87-2815-C-006-075-B from the National Science Council.
Copyright:
Copyright 2004 Elsevier Science B.V., Amsterdam. All rights reserved.
PY - 2000/4/15
Y1 - 2000/4/15
N2 - Application of nonionic surfactants in chemolitholysis was developed to combine two immiscible cholelitholytic solvents, MTBE and EDTA, into a homogeneous solution to increase the efficiency of gallstone dissolution. Eight kinds of Sinopol were employed to investigate and prepare the homogeneous solution, which included MTBE, EDTA (2wt.%) aqueous solution and the Sinopol, thereby, an in vitro study of chemolitholysis was carried out. Three kinds of gallstones were characterized by FTIR and SEM. The dissolution percentage of three kinds of gallstones in the homogeneous (Sinopol mixed) solution was evaluated and a comparison of the average dissolution percentage between these Sinopol mixed solutions and traditional cholelitholytic solvents was made. The composition of gallstones was classified into oil-soluble and water-soluble groups. Furthermore, the hydrophobic and hydrophilic properties of solvents corresponding to oil-soluble and water-soluble gallstone components were analysed and discussed with a phase diagram. Copyright (C) 2000 Elsevier Science B.V.
AB - Application of nonionic surfactants in chemolitholysis was developed to combine two immiscible cholelitholytic solvents, MTBE and EDTA, into a homogeneous solution to increase the efficiency of gallstone dissolution. Eight kinds of Sinopol were employed to investigate and prepare the homogeneous solution, which included MTBE, EDTA (2wt.%) aqueous solution and the Sinopol, thereby, an in vitro study of chemolitholysis was carried out. Three kinds of gallstones were characterized by FTIR and SEM. The dissolution percentage of three kinds of gallstones in the homogeneous (Sinopol mixed) solution was evaluated and a comparison of the average dissolution percentage between these Sinopol mixed solutions and traditional cholelitholytic solvents was made. The composition of gallstones was classified into oil-soluble and water-soluble groups. Furthermore, the hydrophobic and hydrophilic properties of solvents corresponding to oil-soluble and water-soluble gallstone components were analysed and discussed with a phase diagram. Copyright (C) 2000 Elsevier Science B.V.
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U2 - 10.1016/S0927-7765(99)00116-2
DO - 10.1016/S0927-7765(99)00116-2
M3 - Article
AN - SCOPUS:0033966318
SN - 0927-7765
VL - 17
SP - 265
EP - 274
JO - Colloids and Surfaces B: Biointerfaces
JF - Colloids and Surfaces B: Biointerfaces
IS - 4
ER -