Abstract
A variety of functionalities were introduced at 2-aroylquinoline's C5 position, which is considered equivalent to C-3′ of the B-ring of CA4, via Suzuki arylation, Sonogashira ethynylation, and Rosenmund-von Braun cyanation. These substitutions are rarely utilized in the modification of 3′-OH of CA4. The resulting products 6 and 7 having cyano and ethynyl groups exhibited comparable antiproliferative and tubulin inhibitory activities to colchicine.
Original language | English |
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Pages (from-to) | 9593-9600 |
Number of pages | 8 |
Journal | Organic and Biomolecular Chemistry |
Volume | 10 |
Issue number | 48 |
DOIs | |
Publication status | Published - 2012 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry