TY - JOUR
T1 - Application of Ultrasound to Enhancing Stem Cells Associated Therapies
AU - Phan, Thi Nhan
AU - Fan, Ching Hsiang
AU - Yeh, Chih Kuang
N1 - Funding Information:
This work was supported by the National Science and Technology Council, Taiwan under Grant No. MOST 110–2221-E-007–019-MY3, 111–2221-E-007–019-MY3, 111–2321-B-002–014 and 111–2636-E-006–025.
Funding Information:
The authors gratefully acknowledge the support of the National Science and Technology Council , Taiwan under Grant No. MOST 110-2221-E-007-019-MY3, 111-2221-E-007-019-MY3, 111-2321-B-002-014 and 111-2636-E-006-025.
Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2023/8
Y1 - 2023/8
N2 - Pluripotent stem cell therapy exhibits self-renewal capacity and multi-directional differentiation potential and is considered an important regenerative approach for the treatment of several diseases. However, insufficient cell transplantation efficiency, uncontrollable differentiation, low cell viability, and difficult tracing limit its clinical applications and treatment outcome. Ultrasound (US) has mechanical, cavitation, and thermal effects that can produce different biological effects on organs, tissues, and cells. US can be combined with different US-responsive particles for enhanced physical-chemical stimulation and drug delivery. In the meantime, US also can provide a noninvasive and harmless imaging modality for deep tissue in vivo. An in-depth evaluation of the role and mechanism of action of US in stem cell therapy would enhance understanding of US and encourage research in this field. In this article, we comprehensively review progress in the application of US alone and combined with US-responsive particles for the promotion of proliferation, differentiation, migration, and in vivo detection of stem cells and the potential clinical applications. Graphical Abstract: [Figure not available: see fulltext.].
AB - Pluripotent stem cell therapy exhibits self-renewal capacity and multi-directional differentiation potential and is considered an important regenerative approach for the treatment of several diseases. However, insufficient cell transplantation efficiency, uncontrollable differentiation, low cell viability, and difficult tracing limit its clinical applications and treatment outcome. Ultrasound (US) has mechanical, cavitation, and thermal effects that can produce different biological effects on organs, tissues, and cells. US can be combined with different US-responsive particles for enhanced physical-chemical stimulation and drug delivery. In the meantime, US also can provide a noninvasive and harmless imaging modality for deep tissue in vivo. An in-depth evaluation of the role and mechanism of action of US in stem cell therapy would enhance understanding of US and encourage research in this field. In this article, we comprehensively review progress in the application of US alone and combined with US-responsive particles for the promotion of proliferation, differentiation, migration, and in vivo detection of stem cells and the potential clinical applications. Graphical Abstract: [Figure not available: see fulltext.].
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U2 - 10.1007/s12015-023-10546-w
DO - 10.1007/s12015-023-10546-w
M3 - Review article
C2 - 37119453
AN - SCOPUS:85153927949
SN - 2629-3269
VL - 19
SP - 1709
EP - 1725
JO - Stem Cell Reviews and Reports
JF - Stem Cell Reviews and Reports
IS - 6
ER -
