Aptamer-functionalized AlGaN/GaN high-electron-mobility transistor for rapid diagnosis of fibrinogen in human plasma

Tse Yu Tai, Anirban Sinha, Indu Sarangadharan, Anil Kumar Pulikkathodi, Shin Li Wang, Shu Chu Shiesh, Gwo Bin Lee, Yu Lin Wang

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Abstract

In this research, we have developed a rapid diagnostic assay using a high-electron-mobility transistor (HEMT)-based biosensor to screen for fibrinogen in clinical plasma samples. High sensitivity over a wide detection range (0-5 g/L), good selectivity, low-cost fabrication, portability, and simplicity of use are key features of our biosensor. Early diagnosis of heart disease in low-, medium-, and high-risk patients is possible with an assay turn-around time of 5 min and a plasma sample volume of 5-10 μL. High sensitivity and low detection limits (0.5 g/L) are made possible in environments with high salt concentrations because the HEMT sensor design overcomes the charge screening effect associated with a very small Debye length. This biosensor technology demonstrates the potential for development as a point-of-care or homecare diagnostic device for quick and easy assessment of cardiovascular disease (CVD) risk.

Original languageEnglish
Pages (from-to)2321-2331
Number of pages11
JournalSensors and Materials
Volume30
Issue number10
DOIs
Publication statusPublished - 2018 Jan 1

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All Science Journal Classification (ASJC) codes

  • Instrumentation
  • Materials Science(all)

Cite this

Tai, T. Y., Sinha, A., Sarangadharan, I., Pulikkathodi, A. K., Wang, S. L., Shiesh, S. C., Lee, G. B., & Wang, Y. L. (2018). Aptamer-functionalized AlGaN/GaN high-electron-mobility transistor for rapid diagnosis of fibrinogen in human plasma. Sensors and Materials, 30(10), 2321-2331. https://doi.org/10.18494/SAM.2018.1938