TY - JOUR
T1 - Aptamer-functionalized AlGaN/GaN high-electron-mobility transistor for rapid diagnosis of fibrinogen in human plasma
AU - Tai, Tse Yu
AU - Sinha, Anirban
AU - Sarangadharan, Indu
AU - Pulikkathodi, Anil Kumar
AU - Wang, Shin Li
AU - Shiesh, Shu Chu
AU - Lee, Gwo Bin
AU - Wang, Yu Lin
N1 - Funding Information:
This work was supported by the Ministry of Science & Technology (MOST 106-2221-E-007-002-) and National Tsing Hua University in cooperation with Mackay Memorial Hospital in Hsinchu (106J00X9JA). We also express our thanks to the Center for Nanotechnology, Materials Science, and Microsystems (CNMM) at National Tsing Hua University, and to Epi Star Corporation for their continued support.
Publisher Copyright:
© 2018 MYU K.K.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2018
Y1 - 2018
N2 - In this research, we have developed a rapid diagnostic assay using a high-electron-mobility transistor (HEMT)-based biosensor to screen for fibrinogen in clinical plasma samples. High sensitivity over a wide detection range (0-5 g/L), good selectivity, low-cost fabrication, portability, and simplicity of use are key features of our biosensor. Early diagnosis of heart disease in low-, medium-, and high-risk patients is possible with an assay turn-around time of 5 min and a plasma sample volume of 5-10 μL. High sensitivity and low detection limits (0.5 g/L) are made possible in environments with high salt concentrations because the HEMT sensor design overcomes the charge screening effect associated with a very small Debye length. This biosensor technology demonstrates the potential for development as a point-of-care or homecare diagnostic device for quick and easy assessment of cardiovascular disease (CVD) risk.
AB - In this research, we have developed a rapid diagnostic assay using a high-electron-mobility transistor (HEMT)-based biosensor to screen for fibrinogen in clinical plasma samples. High sensitivity over a wide detection range (0-5 g/L), good selectivity, low-cost fabrication, portability, and simplicity of use are key features of our biosensor. Early diagnosis of heart disease in low-, medium-, and high-risk patients is possible with an assay turn-around time of 5 min and a plasma sample volume of 5-10 μL. High sensitivity and low detection limits (0.5 g/L) are made possible in environments with high salt concentrations because the HEMT sensor design overcomes the charge screening effect associated with a very small Debye length. This biosensor technology demonstrates the potential for development as a point-of-care or homecare diagnostic device for quick and easy assessment of cardiovascular disease (CVD) risk.
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U2 - 10.18494/SAM.2018.1938
DO - 10.18494/SAM.2018.1938
M3 - Article
AN - SCOPUS:85055646360
SN - 0914-4935
VL - 30
SP - 2321
EP - 2331
JO - Sensors and Materials
JF - Sensors and Materials
IS - 10
ER -
