TY - JOUR
T1 - Aquatic viruses induce host cell death pathways and its application
AU - Reshi, Latif
AU - Wu, Jen Leih
AU - Wang, Hao Ven
AU - Hong, Jiann Ruey
N1 - Funding Information:
This work was supported by grants (NSC-99-2321-B-006-010-MY3) awarded to Dr. Jainn-Ruey Hong from the National Science Council, Taiwan, Republic of China.
Publisher Copyright:
© 2015 Elsevier B.V..
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/1/4
Y1 - 2016/1/4
N2 - Virus infections of mammalian and animal cells consist of a series of events. As intracellular parasites, viruses rely on the use of host cellular machinery. Through the use of cell culture and molecular approaches over the past decade, our knowledge of the biology of aquatic viruses has grown exponentially. The increase in aquaculture operations worldwide has provided new approaches for the transmission of aquatic viruses that include RNA and DNA viruses. Therefore, the struggle between the virus and the host for control of the cell's death machinery is crucial for survival. Viruses are obligatory intracellular parasites and, as such, must modulate apoptotic pathways to control the lifespan of their host to complete their replication cycle. This paper updates the discussion on the detailed mechanisms of action that various aquatic viruses use to induce cell death pathways in the host, such as Bad-mediated, mitochondria-mediated, ROS-mediated and Fas-mediated cell death circuits. Understanding how viruses exploit the apoptotic pathways of their hosts may provide great opportunities for the development of future potential therapeutic strategies and pathogenic insights into different aquatic viral diseases.
AB - Virus infections of mammalian and animal cells consist of a series of events. As intracellular parasites, viruses rely on the use of host cellular machinery. Through the use of cell culture and molecular approaches over the past decade, our knowledge of the biology of aquatic viruses has grown exponentially. The increase in aquaculture operations worldwide has provided new approaches for the transmission of aquatic viruses that include RNA and DNA viruses. Therefore, the struggle between the virus and the host for control of the cell's death machinery is crucial for survival. Viruses are obligatory intracellular parasites and, as such, must modulate apoptotic pathways to control the lifespan of their host to complete their replication cycle. This paper updates the discussion on the detailed mechanisms of action that various aquatic viruses use to induce cell death pathways in the host, such as Bad-mediated, mitochondria-mediated, ROS-mediated and Fas-mediated cell death circuits. Understanding how viruses exploit the apoptotic pathways of their hosts may provide great opportunities for the development of future potential therapeutic strategies and pathogenic insights into different aquatic viral diseases.
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U2 - 10.1016/j.virusres.2015.10.018
DO - 10.1016/j.virusres.2015.10.018
M3 - Review article
C2 - 26494167
AN - SCOPUS:84951815415
VL - 211
SP - 133
EP - 144
JO - Virus Research
JF - Virus Research
SN - 0168-1702
ER -