TY - JOUR
T1 - Argon-plasma-treated chitosan
T2 - Surface characterization and initial attachment of osteoblasts
AU - Wu, Yu Chun
AU - Lee, Tzer Min
AU - Lin, Jui Che
AU - Shaw, Shyh Yu
AU - Yang, Chyun Yu
N1 - Funding Information:
This work was supported in part by grant NSC 96-2314-B-006-035 from the National Science Council, Taiwan. We thank Mr. Bill Franky for his help with the preparation of this manuscript and Mr. Ming Che Hsieh for performing atom force microscopy. We also would like to thank the Instrument Center at National Chung Cheng University for assistance with XPS spectra.
PY - 2010/3/1
Y1 - 2010/3/1
N2 - Chitosan is a biocompatible, biodegradable and non-toxic material. It is also an advanced material used for wound dressings, drug and gene delivery, and tissue engineering. In this study, we treated chitosan film with argon plasma and characterized both its physical and chemical properties. We found that argon plasma increased nano-scale roughness and introduced a carbonyl group to the chitosan surface. Meanwhile, the contact angles also decreased as the duration of the plasma treatment on chitosan was prolonged, indicating that the increased roughness and carbonyl group promote the hydrophilicity of the chitosan film surface. Moreover, the number of osteoblasts adhering to chitosan films increased and their morphology became flatter with longer plasma treatments. In conclusion, this study first demonstrates that plasma treatment on chitosan exerting surface-property change is capable of triggering the initial attachment of osteoblasts to chitosan surfaces.
AB - Chitosan is a biocompatible, biodegradable and non-toxic material. It is also an advanced material used for wound dressings, drug and gene delivery, and tissue engineering. In this study, we treated chitosan film with argon plasma and characterized both its physical and chemical properties. We found that argon plasma increased nano-scale roughness and introduced a carbonyl group to the chitosan surface. Meanwhile, the contact angles also decreased as the duration of the plasma treatment on chitosan was prolonged, indicating that the increased roughness and carbonyl group promote the hydrophilicity of the chitosan film surface. Moreover, the number of osteoblasts adhering to chitosan films increased and their morphology became flatter with longer plasma treatments. In conclusion, this study first demonstrates that plasma treatment on chitosan exerting surface-property change is capable of triggering the initial attachment of osteoblasts to chitosan surfaces.
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U2 - 10.1163/156856209X430227
DO - 10.1163/156856209X430227
M3 - Article
C2 - 20338092
AN - SCOPUS:77950252108
SN - 0920-5063
VL - 21
SP - 563
EP - 579
JO - Journal of Biomaterials Science, Polymer Edition
JF - Journal of Biomaterials Science, Polymer Edition
IS - 5
ER -