Argon-plasma-treated chitosan: Surface characterization and initial attachment of osteoblasts

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Abstract

Chitosan is a biocompatible, biodegradable and non-toxic material. It is also an advanced material used for wound dressings, drug and gene delivery, and tissue engineering. In this study, we treated chitosan film with argon plasma and characterized both its physical and chemical properties. We found that argon plasma increased nano-scale roughness and introduced a carbonyl group to the chitosan surface. Meanwhile, the contact angles also decreased as the duration of the plasma treatment on chitosan was prolonged, indicating that the increased roughness and carbonyl group promote the hydrophilicity of the chitosan film surface. Moreover, the number of osteoblasts adhering to chitosan films increased and their morphology became flatter with longer plasma treatments. In conclusion, this study first demonstrates that plasma treatment on chitosan exerting surface-property change is capable of triggering the initial attachment of osteoblasts to chitosan surfaces.

Original languageEnglish
Pages (from-to)563-579
Number of pages17
JournalJournal of Biomaterials Science, Polymer Edition
Volume21
Issue number5
DOIs
Publication statusPublished - 2010 Mar 1

Fingerprint

Argon
Osteoblasts
Chitosan
Plasmas
Surface roughness
Surface Properties
Hydrophilicity
Tissue Engineering
Bandages
Hydrophobic and Hydrophilic Interactions
Tissue engineering
Chemical properties
Contact angle
Surface properties
Physical properties
Genes
Wounds and Injuries
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

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abstract = "Chitosan is a biocompatible, biodegradable and non-toxic material. It is also an advanced material used for wound dressings, drug and gene delivery, and tissue engineering. In this study, we treated chitosan film with argon plasma and characterized both its physical and chemical properties. We found that argon plasma increased nano-scale roughness and introduced a carbonyl group to the chitosan surface. Meanwhile, the contact angles also decreased as the duration of the plasma treatment on chitosan was prolonged, indicating that the increased roughness and carbonyl group promote the hydrophilicity of the chitosan film surface. Moreover, the number of osteoblasts adhering to chitosan films increased and their morphology became flatter with longer plasma treatments. In conclusion, this study first demonstrates that plasma treatment on chitosan exerting surface-property change is capable of triggering the initial attachment of osteoblasts to chitosan surfaces.",
author = "Wu, {Yu Chun} and Lee, {Tzer Min} and Lin, {Jui Che} and Shaw, {Shyh Yu} and Yang, {Chyun Yu}",
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T2 - Surface characterization and initial attachment of osteoblasts

AU - Wu, Yu Chun

AU - Lee, Tzer Min

AU - Lin, Jui Che

AU - Shaw, Shyh Yu

AU - Yang, Chyun Yu

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AB - Chitosan is a biocompatible, biodegradable and non-toxic material. It is also an advanced material used for wound dressings, drug and gene delivery, and tissue engineering. In this study, we treated chitosan film with argon plasma and characterized both its physical and chemical properties. We found that argon plasma increased nano-scale roughness and introduced a carbonyl group to the chitosan surface. Meanwhile, the contact angles also decreased as the duration of the plasma treatment on chitosan was prolonged, indicating that the increased roughness and carbonyl group promote the hydrophilicity of the chitosan film surface. Moreover, the number of osteoblasts adhering to chitosan films increased and their morphology became flatter with longer plasma treatments. In conclusion, this study first demonstrates that plasma treatment on chitosan exerting surface-property change is capable of triggering the initial attachment of osteoblasts to chitosan surfaces.

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