Arsenic, vinyl chloride, viral hepatitis, and hepatic angiosarcoma

A hospital-based study and review of literature in Taiwan

Neng Chyan Huang, Shue Ren Wann, Hong Tai Chang, Shoa Lin Lin, Jyh Seng Wang, How-Ran Guo

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background: Hepatic angiosarcoma (HAS) is a rare type of liver cancer that is often fatal, and arsenic and vinyl chloride monomer (VCM) are two major causal agents. Whereas Taiwan is an endemic area of liver cancer, epidemiologic data on HAS are limited. We reviewed the cases observed at a teaching hospital to evaluate the roles of VCM, arsenic, and viral hepatitis in the occurrence of HAS.Methods: We reviewed the medical records of patients with pathological proof of HAS from January 2000 to August 2010 at a teaching hospital which is adjacent to the major VCM processing area in Taiwan and nearby an endemic area of arsenic exposure from drinking water. We also conducted a literature review and included all patients of HAS reported in Taiwan.Results: Six male and three female cases aged from 56 to 83 years (64.6 ± 8.2 years) were identified at the hospital. The differences in clinical features between men and women were not statistically significant. None of them had exposure to VCM or arsenic in drinking water. Two had evidence of hepatitis C infection, but none had evidence of hepatitis B infection. Five male and four female cases aged 30 to 82 years (58.6 ± 15.5 years) were identified in the literature, including two with arsenic exposure and one with chronic hepatitis B infection.Conclusions: HAS is rare in Taiwan, and we found no evidence supporting a major role of VCM, arsenic in drinking water, or viral hepatitis in its occurrence.

Original languageEnglish
Article number142
JournalBMC Gastroenterology
Volume11
DOIs
Publication statusPublished - 2011 Dec 26

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Vinyl Chloride
Hemangiosarcoma
Arsenic
Taiwan
Hepatitis
Liver
Drinking Water
Liver Neoplasms
Teaching Hospitals
Infection
Chronic Hepatitis B
Hepatitis C
Hepatitis B
Medical Records

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Huang, Neng Chyan ; Wann, Shue Ren ; Chang, Hong Tai ; Lin, Shoa Lin ; Wang, Jyh Seng ; Guo, How-Ran. / Arsenic, vinyl chloride, viral hepatitis, and hepatic angiosarcoma : A hospital-based study and review of literature in Taiwan. In: BMC Gastroenterology. 2011 ; Vol. 11.
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abstract = "Background: Hepatic angiosarcoma (HAS) is a rare type of liver cancer that is often fatal, and arsenic and vinyl chloride monomer (VCM) are two major causal agents. Whereas Taiwan is an endemic area of liver cancer, epidemiologic data on HAS are limited. We reviewed the cases observed at a teaching hospital to evaluate the roles of VCM, arsenic, and viral hepatitis in the occurrence of HAS.Methods: We reviewed the medical records of patients with pathological proof of HAS from January 2000 to August 2010 at a teaching hospital which is adjacent to the major VCM processing area in Taiwan and nearby an endemic area of arsenic exposure from drinking water. We also conducted a literature review and included all patients of HAS reported in Taiwan.Results: Six male and three female cases aged from 56 to 83 years (64.6 ± 8.2 years) were identified at the hospital. The differences in clinical features between men and women were not statistically significant. None of them had exposure to VCM or arsenic in drinking water. Two had evidence of hepatitis C infection, but none had evidence of hepatitis B infection. Five male and four female cases aged 30 to 82 years (58.6 ± 15.5 years) were identified in the literature, including two with arsenic exposure and one with chronic hepatitis B infection.Conclusions: HAS is rare in Taiwan, and we found no evidence supporting a major role of VCM, arsenic in drinking water, or viral hepatitis in its occurrence.",
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Arsenic, vinyl chloride, viral hepatitis, and hepatic angiosarcoma : A hospital-based study and review of literature in Taiwan. / Huang, Neng Chyan; Wann, Shue Ren; Chang, Hong Tai; Lin, Shoa Lin; Wang, Jyh Seng; Guo, How-Ran.

In: BMC Gastroenterology, Vol. 11, 142, 26.12.2011.

Research output: Contribution to journalArticle

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AB - Background: Hepatic angiosarcoma (HAS) is a rare type of liver cancer that is often fatal, and arsenic and vinyl chloride monomer (VCM) are two major causal agents. Whereas Taiwan is an endemic area of liver cancer, epidemiologic data on HAS are limited. We reviewed the cases observed at a teaching hospital to evaluate the roles of VCM, arsenic, and viral hepatitis in the occurrence of HAS.Methods: We reviewed the medical records of patients with pathological proof of HAS from January 2000 to August 2010 at a teaching hospital which is adjacent to the major VCM processing area in Taiwan and nearby an endemic area of arsenic exposure from drinking water. We also conducted a literature review and included all patients of HAS reported in Taiwan.Results: Six male and three female cases aged from 56 to 83 years (64.6 ± 8.2 years) were identified at the hospital. The differences in clinical features between men and women were not statistically significant. None of them had exposure to VCM or arsenic in drinking water. Two had evidence of hepatitis C infection, but none had evidence of hepatitis B infection. Five male and four female cases aged 30 to 82 years (58.6 ± 15.5 years) were identified in the literature, including two with arsenic exposure and one with chronic hepatitis B infection.Conclusions: HAS is rare in Taiwan, and we found no evidence supporting a major role of VCM, arsenic in drinking water, or viral hepatitis in its occurrence.

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