Assessment of ischemic stroke rat using near infrared spectroscopy

F. M. Yang, C. W. Wu, C. Y. Lu, Jia-Jin Chen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Although varied approaches have been developed for quantifying the severity of cerebral dysfunction under ischemic stroke, the neurological scoring and behavior assessment cannot provide noninvasively time-course assessment. The aims of this study are to design non-invasive electrophysiological and optical method to assess the brain recovery of ischemic stroke. The recording system for somatosensory evoked potentials (SSEPs) using surface electrode and neurovascular response using near infrared spectroscopy (NIRS) was developed. A cranial probe was designed to arrange sensing electrodes and optical fibers for concurrent electrical and optical signal acquisition. The pin electrodes consist of spring electrode probe which can provide the well-contact between brain skull and electrode. The Continuous-Wave (CW) NIRS was employed to monitor in-vivo hemodynamic response using avalanche photodiodes (APD). Our results of SSEPs show decayed P1-N1 amplitude and frequency shifted in time frquency analysis after cerebral ischemia. In the future study, our NIRS system will be expanded to employ three wavelengths, which allows the assessment of cytochrome C oxidase. The integration of neurovascular assessment and low level laser therapy (LLLT) system should provide useful tool for time-course monitoring of various novel treatments to the animal of ischemic stroke.

Original languageEnglish
Title of host publication5th Kuala Lumpur International Conference on Biomedical Engineering 2011, BIOMED 2011
Pages600-603
Number of pages4
DOIs
Publication statusPublished - 2011 Jul 11
Event5th Kuala Lumpur International Conference on Biomedical Engineering, BIOMED 2011, Held in Conjunction with the 8th Asian Pacific Conference on Medical and Biological Engineering, APCMBE 2011 - Kuala Lumpur, Malaysia
Duration: 2011 Jun 202011 Jun 23

Publication series

NameIFMBE Proceedings
Volume35 IFMBE
ISSN (Print)1680-0737

Other

Other5th Kuala Lumpur International Conference on Biomedical Engineering, BIOMED 2011, Held in Conjunction with the 8th Asian Pacific Conference on Medical and Biological Engineering, APCMBE 2011
CountryMalaysia
CityKuala Lumpur
Period11-06-2011-06-23

Fingerprint

Near infrared spectroscopy
Rats
Electrodes
Bioelectric potentials
Brain
Avalanche photodiodes
Hemodynamics
Cytochromes
Optical fibers
Oxidoreductases
Animals
Proteins
Recovery
Wavelength
Lasers
Monitoring

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomedical Engineering

Cite this

Yang, F. M., Wu, C. W., Lu, C. Y., & Chen, J-J. (2011). Assessment of ischemic stroke rat using near infrared spectroscopy. In 5th Kuala Lumpur International Conference on Biomedical Engineering 2011, BIOMED 2011 (pp. 600-603). (IFMBE Proceedings; Vol. 35 IFMBE). https://doi.org/10.1007/978-3-642-21729-6_149
Yang, F. M. ; Wu, C. W. ; Lu, C. Y. ; Chen, Jia-Jin. / Assessment of ischemic stroke rat using near infrared spectroscopy. 5th Kuala Lumpur International Conference on Biomedical Engineering 2011, BIOMED 2011. 2011. pp. 600-603 (IFMBE Proceedings).
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Yang, FM, Wu, CW, Lu, CY & Chen, J-J 2011, Assessment of ischemic stroke rat using near infrared spectroscopy. in 5th Kuala Lumpur International Conference on Biomedical Engineering 2011, BIOMED 2011. IFMBE Proceedings, vol. 35 IFMBE, pp. 600-603, 5th Kuala Lumpur International Conference on Biomedical Engineering, BIOMED 2011, Held in Conjunction with the 8th Asian Pacific Conference on Medical and Biological Engineering, APCMBE 2011, Kuala Lumpur, Malaysia, 11-06-20. https://doi.org/10.1007/978-3-642-21729-6_149

Assessment of ischemic stroke rat using near infrared spectroscopy. / Yang, F. M.; Wu, C. W.; Lu, C. Y.; Chen, Jia-Jin.

5th Kuala Lumpur International Conference on Biomedical Engineering 2011, BIOMED 2011. 2011. p. 600-603 (IFMBE Proceedings; Vol. 35 IFMBE).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Yang FM, Wu CW, Lu CY, Chen J-J. Assessment of ischemic stroke rat using near infrared spectroscopy. In 5th Kuala Lumpur International Conference on Biomedical Engineering 2011, BIOMED 2011. 2011. p. 600-603. (IFMBE Proceedings). https://doi.org/10.1007/978-3-642-21729-6_149