Assessment of optical properties in cerebral ischemic rats by using near infrared spectroscopy

Wan Chen Shao, Chun Wei Wu, Chun Man Yuan, Jia Jin Jason Chen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Ischemic stroke is a high prevailing disease and costly in industrialized countries. A valid animal model is essential to develop an extensive research. Among various models, we choose middle cerebral artery occlusion (MCAO) model as it is one of the common used ischemic stroke animal models. The purpose of our study is to investigate the optical properties of ischemic stroke by near infrared spectroscopy (NIRS) with the wavelength in 830 and 690 nm. The optical properties include the absorption coefficient, reduced scattering coefficient and hemodynamic responses. It shows that the correlation between the reduced scattering coefficient and the brain infarction volume from histochemical stain is high in 830 nm, and moderate in 690 nm. Besides, there is significant difference in reduced scattering coefficient between infarction region at cortex and subcortex and that at subcortex only or sham group. These results show that NIRS can be an effective tool to evaluate ischemic stroke.

Original languageEnglish
Title of host publicationIECBES 2014, Conference Proceedings - 2014 IEEE Conference on Biomedical Engineering and Sciences
Subtitle of host publication"Miri, Where Engineering in Medicine and Biology and Humanity Meet"
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages807-810
Number of pages4
ISBN (Electronic)9781479940844
DOIs
Publication statusPublished - 2014
Event3rd IEEE Conference on Biomedical Engineering and Sciences, IECBES 2014 - Kuala Lumpur, Malaysia
Duration: 2014 Dec 82014 Dec 10

Publication series

NameIECBES 2014, Conference Proceedings - 2014 IEEE Conference on Biomedical Engineering and Sciences: "Miri, Where Engineering in Medicine and Biology and Humanity Meet"

Other

Other3rd IEEE Conference on Biomedical Engineering and Sciences, IECBES 2014
CountryMalaysia
CityKuala Lumpur
Period14-12-0814-12-10

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

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