TY - JOUR
T1 - Association between auditory P300, psychopathology, and memory function in drug-naïve schizophrenia
AU - Chang, Wei Hung
AU - Chen, Kao Chin
AU - Yang, Yen Kuang
AU - Chen, Po See
AU - Lu, Ru Band
AU - Yeh, Tzung Lieh
AU - Wang, Carol Sheei Meei
AU - Lee, I. Hui
N1 - Funding Information:
The authors thank Ms. Tsai Hua Chang and Mr. Chien Ting Lin for administrative support. This work was supported by grants from the National Science Council of Taiwan ( NSC 93-2314-B-006-107 , NSC 95-2314-B-006-052 , and NSC 99-2314-B-006-019-MY3 ) and Atomic Energy Council of Taiwan ( NSC 91-NU-7-006-002 ). The institutions funding this study had no further role in the study design, the collection, analysis and interpretation of data, the writing of this paper, or the decision to submit for publication.
PY - 2014/3
Y1 - 2014/3
N2 - The aim of this study was to explore memory deficits and psychopathology and their relationships with P300 in drug-naïve patients with schizophrenia. The Positive and Negative Syndrome Scale (PANSS) and the Wechsler Memory Scale - Revised were administered. Auditory event-related potentials elicited by an oddball paradigm were obtained. After controlling for age, sex, the results showed a statistically significant negative correlation between the total PANSS score and P300 amplitude at the parietal position (r = -0.66, p < 0.05). Moreover, visual memory was significantly positively correlated with P300 amplitude at the parietal position (r = 0.67, p < 0.05). After controlling for the duration of illness, the above correlations remained statistically significant. The correlation between P300 and the severity of psychopathology was reconfirmed in drug-naïve patients with schizophrenia. A possible contribution of memory decompensation in P300 among drug-naïve patients with schizophrenia may be considered, and the compensatory or Default Model Network might be a possible explanation of this association.
AB - The aim of this study was to explore memory deficits and psychopathology and their relationships with P300 in drug-naïve patients with schizophrenia. The Positive and Negative Syndrome Scale (PANSS) and the Wechsler Memory Scale - Revised were administered. Auditory event-related potentials elicited by an oddball paradigm were obtained. After controlling for age, sex, the results showed a statistically significant negative correlation between the total PANSS score and P300 amplitude at the parietal position (r = -0.66, p < 0.05). Moreover, visual memory was significantly positively correlated with P300 amplitude at the parietal position (r = 0.67, p < 0.05). After controlling for the duration of illness, the above correlations remained statistically significant. The correlation between P300 and the severity of psychopathology was reconfirmed in drug-naïve patients with schizophrenia. A possible contribution of memory decompensation in P300 among drug-naïve patients with schizophrenia may be considered, and the compensatory or Default Model Network might be a possible explanation of this association.
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U2 - 10.1016/j.kjms.2013.10.003
DO - 10.1016/j.kjms.2013.10.003
M3 - Article
C2 - 24581213
AN - SCOPUS:84896734759
VL - 30
SP - 133
EP - 138
JO - Kaohsiung Journal of Medical Sciences
JF - Kaohsiung Journal of Medical Sciences
SN - 1607-551X
IS - 3
ER -