Association between auditory P300, psychopathology, and memory function in drug-naïve schizophrenia

Wei Hung Chang, Kao Chin Chen, Yen Kuang Yang, Po See Chen, Ru Band Lu, Tzung Lieh Yeh, Carol Sheei Meei Wang, I. Hui Lee

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The aim of this study was to explore memory deficits and psychopathology and their relationships with P300 in drug-naïve patients with schizophrenia. The Positive and Negative Syndrome Scale (PANSS) and the Wechsler Memory Scale - Revised were administered. Auditory event-related potentials elicited by an oddball paradigm were obtained. After controlling for age, sex, the results showed a statistically significant negative correlation between the total PANSS score and P300 amplitude at the parietal position (r = -0.66, p < 0.05). Moreover, visual memory was significantly positively correlated with P300 amplitude at the parietal position (r = 0.67, p < 0.05). After controlling for the duration of illness, the above correlations remained statistically significant. The correlation between P300 and the severity of psychopathology was reconfirmed in drug-naïve patients with schizophrenia. A possible contribution of memory decompensation in P300 among drug-naïve patients with schizophrenia may be considered, and the compensatory or Default Model Network might be a possible explanation of this association.

Original languageEnglish
Pages (from-to)133-138
Number of pages6
JournalKaohsiung Journal of Medical Sciences
Volume30
Issue number3
DOIs
Publication statusPublished - 2014 Mar 1

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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