Association between blood dioxin level and chronic kidney disease in an endemic area of exposure

Chien Yuan Huang, Cheng Long Wu, Jin-Shang Wu, Jung Wei Chang, Ya Yun Cheng, Yau-Chang Kuo, Yi-Ching Yang, Ching-Chang Lee, How-Ran Guo

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Dioxin is an industrial pollutant related to various diseases, but epidemiological data on its effects on the kidney are limited. Therefore, we conducted a study to evaluate the association between dioxin exposure and chronic kidney disease (CKD) and identify the related factors. Methods: We conducted a community-based cross-sectional study and recruited participants from an area where the residents were exposed to dioxin released from a factory. We defined a "high dioxin level" as polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) ≥ 20 pg WHO98-TEQDF/g lipid in the serum and defined CKD as having an estimated glomerular filtration rate (e-GFR) ≤ 60 mL/min/1.73m2 or a diagnosis of CKD by a physician. The renal function was assessed between 2005 and 2010, and we excluded those who had had kidney diseases before the study started. Comparisons between patients of CKD and those who did not have CKD were made to identify the risk factors for CKD. Results: Of the 2898 participants, 1427 had high dioxin levels, and 156 had CKD. In the univariate analyses, CKD was associated with high dioxin levels, age, gender, metabolic syndrome, diabetes mellitus, hypertension, and high insulin and uric acid levels. After adjusting for other factors, we found high dioxin levels (adjusted odds ratio [AOR] = 1.76, 95% confidence interval [CI]: 1.04-2.99), female gender (AOR = 1.74, 95%CI: 1.20-2.53), hypertension (AOR = 1.68, 95%CI: 1.17-2.42), high insulin levels (AOR = 2.14, 95% CI: 1.26-3.61), high uric acid levels (AOR = 4.25, 95% CI: 2.92-6.20), and older age (AOR = 4.66, 95% CI: 1.87-11.62 for 40-64 year and AOR = 26.66, 95% CI: 10.51-67.62 for age ≥ 65 year) were independent predictors of CKD. Conclusion: A high dioxin level was associated with an increased prevalence of CKD. Therefore, the kidney function of populations with exposure to dioxin should be monitored.

Original languageEnglish
Article numbere0150248
JournalPloS one
Volume11
Issue number3
DOIs
Publication statusPublished - 2016 Mar 1

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Dioxins
dioxins
kidney diseases
Chronic Renal Insufficiency
Blood
odds ratio
blood
confidence interval
Odds Ratio
Confidence Intervals
Uric Acid
Kidney
renal function
uric acid
hypertension
insulin
Insulin
Hypertension
dibenzofuran
polychlorinated dibenzodioxins

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

@article{606ddf121e574466be917e42bd9c9c45,
title = "Association between blood dioxin level and chronic kidney disease in an endemic area of exposure",
abstract = "Background: Dioxin is an industrial pollutant related to various diseases, but epidemiological data on its effects on the kidney are limited. Therefore, we conducted a study to evaluate the association between dioxin exposure and chronic kidney disease (CKD) and identify the related factors. Methods: We conducted a community-based cross-sectional study and recruited participants from an area where the residents were exposed to dioxin released from a factory. We defined a {"}high dioxin level{"} as polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) ≥ 20 pg WHO98-TEQDF/g lipid in the serum and defined CKD as having an estimated glomerular filtration rate (e-GFR) ≤ 60 mL/min/1.73m2 or a diagnosis of CKD by a physician. The renal function was assessed between 2005 and 2010, and we excluded those who had had kidney diseases before the study started. Comparisons between patients of CKD and those who did not have CKD were made to identify the risk factors for CKD. Results: Of the 2898 participants, 1427 had high dioxin levels, and 156 had CKD. In the univariate analyses, CKD was associated with high dioxin levels, age, gender, metabolic syndrome, diabetes mellitus, hypertension, and high insulin and uric acid levels. After adjusting for other factors, we found high dioxin levels (adjusted odds ratio [AOR] = 1.76, 95{\%} confidence interval [CI]: 1.04-2.99), female gender (AOR = 1.74, 95{\%}CI: 1.20-2.53), hypertension (AOR = 1.68, 95{\%}CI: 1.17-2.42), high insulin levels (AOR = 2.14, 95{\%} CI: 1.26-3.61), high uric acid levels (AOR = 4.25, 95{\%} CI: 2.92-6.20), and older age (AOR = 4.66, 95{\%} CI: 1.87-11.62 for 40-64 year and AOR = 26.66, 95{\%} CI: 10.51-67.62 for age ≥ 65 year) were independent predictors of CKD. Conclusion: A high dioxin level was associated with an increased prevalence of CKD. Therefore, the kidney function of populations with exposure to dioxin should be monitored.",
author = "Huang, {Chien Yuan} and Wu, {Cheng Long} and Jin-Shang Wu and Chang, {Jung Wei} and Cheng, {Ya Yun} and Yau-Chang Kuo and Yi-Ching Yang and Ching-Chang Lee and How-Ran Guo",
year = "2016",
month = "3",
day = "1",
doi = "10.1371/journal.pone.0150248",
language = "English",
volume = "11",
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Association between blood dioxin level and chronic kidney disease in an endemic area of exposure. / Huang, Chien Yuan; Wu, Cheng Long; Wu, Jin-Shang; Chang, Jung Wei; Cheng, Ya Yun; Kuo, Yau-Chang; Yang, Yi-Ching; Lee, Ching-Chang; Guo, How-Ran.

In: PloS one, Vol. 11, No. 3, e0150248, 01.03.2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association between blood dioxin level and chronic kidney disease in an endemic area of exposure

AU - Huang, Chien Yuan

AU - Wu, Cheng Long

AU - Wu, Jin-Shang

AU - Chang, Jung Wei

AU - Cheng, Ya Yun

AU - Kuo, Yau-Chang

AU - Yang, Yi-Ching

AU - Lee, Ching-Chang

AU - Guo, How-Ran

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Background: Dioxin is an industrial pollutant related to various diseases, but epidemiological data on its effects on the kidney are limited. Therefore, we conducted a study to evaluate the association between dioxin exposure and chronic kidney disease (CKD) and identify the related factors. Methods: We conducted a community-based cross-sectional study and recruited participants from an area where the residents were exposed to dioxin released from a factory. We defined a "high dioxin level" as polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) ≥ 20 pg WHO98-TEQDF/g lipid in the serum and defined CKD as having an estimated glomerular filtration rate (e-GFR) ≤ 60 mL/min/1.73m2 or a diagnosis of CKD by a physician. The renal function was assessed between 2005 and 2010, and we excluded those who had had kidney diseases before the study started. Comparisons between patients of CKD and those who did not have CKD were made to identify the risk factors for CKD. Results: Of the 2898 participants, 1427 had high dioxin levels, and 156 had CKD. In the univariate analyses, CKD was associated with high dioxin levels, age, gender, metabolic syndrome, diabetes mellitus, hypertension, and high insulin and uric acid levels. After adjusting for other factors, we found high dioxin levels (adjusted odds ratio [AOR] = 1.76, 95% confidence interval [CI]: 1.04-2.99), female gender (AOR = 1.74, 95%CI: 1.20-2.53), hypertension (AOR = 1.68, 95%CI: 1.17-2.42), high insulin levels (AOR = 2.14, 95% CI: 1.26-3.61), high uric acid levels (AOR = 4.25, 95% CI: 2.92-6.20), and older age (AOR = 4.66, 95% CI: 1.87-11.62 for 40-64 year and AOR = 26.66, 95% CI: 10.51-67.62 for age ≥ 65 year) were independent predictors of CKD. Conclusion: A high dioxin level was associated with an increased prevalence of CKD. Therefore, the kidney function of populations with exposure to dioxin should be monitored.

AB - Background: Dioxin is an industrial pollutant related to various diseases, but epidemiological data on its effects on the kidney are limited. Therefore, we conducted a study to evaluate the association between dioxin exposure and chronic kidney disease (CKD) and identify the related factors. Methods: We conducted a community-based cross-sectional study and recruited participants from an area where the residents were exposed to dioxin released from a factory. We defined a "high dioxin level" as polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) ≥ 20 pg WHO98-TEQDF/g lipid in the serum and defined CKD as having an estimated glomerular filtration rate (e-GFR) ≤ 60 mL/min/1.73m2 or a diagnosis of CKD by a physician. The renal function was assessed between 2005 and 2010, and we excluded those who had had kidney diseases before the study started. Comparisons between patients of CKD and those who did not have CKD were made to identify the risk factors for CKD. Results: Of the 2898 participants, 1427 had high dioxin levels, and 156 had CKD. In the univariate analyses, CKD was associated with high dioxin levels, age, gender, metabolic syndrome, diabetes mellitus, hypertension, and high insulin and uric acid levels. After adjusting for other factors, we found high dioxin levels (adjusted odds ratio [AOR] = 1.76, 95% confidence interval [CI]: 1.04-2.99), female gender (AOR = 1.74, 95%CI: 1.20-2.53), hypertension (AOR = 1.68, 95%CI: 1.17-2.42), high insulin levels (AOR = 2.14, 95% CI: 1.26-3.61), high uric acid levels (AOR = 4.25, 95% CI: 2.92-6.20), and older age (AOR = 4.66, 95% CI: 1.87-11.62 for 40-64 year and AOR = 26.66, 95% CI: 10.51-67.62 for age ≥ 65 year) were independent predictors of CKD. Conclusion: A high dioxin level was associated with an increased prevalence of CKD. Therefore, the kidney function of populations with exposure to dioxin should be monitored.

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SN - 1932-6203

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