Association between blood level of plasma oxytocin and novelty seeking among methadone-maintained heroin users

Shih Hsien Lin, Lan-Ting Lee, Hsin-Chun Tsai, Kao-Ching Chen, Wei Tseng Chen, I-Hui Lee, Ru-Band Lu, Po-See Chen, Yen-Kuang Yang

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9 Citations (Scopus)

Abstract

Background: Oxytocin interacts with the dopaminergic system, which plays a role in addiction behaviors. The association between oxytocin and addiction was confirmed in animal studies. Novelty seeking is one of the predictors and indicators of drug addiction. The aim of the present study was to probe the association between oxytocin and novelty seeking. Methods: The study was conducted in a methadone maintenance therapy clinic of a medical center in Taiwan; 77 patients with heroin dependency were enrolled. Plasma oxytocin was measured using an ELISA kit. Novelty seeking was measured using an established instrument (the novelty seeking subscale of the Tridimensional Personality Questionnaire). Results: A significant negative association (ρ = -0.27, p = 0.02; r = -0.34, p = 0.003) between the blood level of plasma oxytocin and novelty seeking was found. This association was significant after controlling the effects of perceived social support and the dosage of methadone (r = -0.32, p = 0.006). Conclusion: The negative association between oxytocin and novelty seeking may provide insight into future treatments for addiction.

Original languageEnglish
Pages (from-to)65-69
Number of pages5
JournalNeuropsychobiology
Volume71
Issue number2
DOIs
Publication statusPublished - 2015 May 6

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Methadone
Heroin
Oxytocin
Taiwan
Social Support
Substance-Related Disorders
Personality
Enzyme-Linked Immunosorbent Assay
Therapeutics

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

@article{d9217ec64f1248d2b8431584b7f9c438,
title = "Association between blood level of plasma oxytocin and novelty seeking among methadone-maintained heroin users",
abstract = "Background: Oxytocin interacts with the dopaminergic system, which plays a role in addiction behaviors. The association between oxytocin and addiction was confirmed in animal studies. Novelty seeking is one of the predictors and indicators of drug addiction. The aim of the present study was to probe the association between oxytocin and novelty seeking. Methods: The study was conducted in a methadone maintenance therapy clinic of a medical center in Taiwan; 77 patients with heroin dependency were enrolled. Plasma oxytocin was measured using an ELISA kit. Novelty seeking was measured using an established instrument (the novelty seeking subscale of the Tridimensional Personality Questionnaire). Results: A significant negative association (ρ = -0.27, p = 0.02; r = -0.34, p = 0.003) between the blood level of plasma oxytocin and novelty seeking was found. This association was significant after controlling the effects of perceived social support and the dosage of methadone (r = -0.32, p = 0.006). Conclusion: The negative association between oxytocin and novelty seeking may provide insight into future treatments for addiction.",
author = "Lin, {Shih Hsien} and Lan-Ting Lee and Hsin-Chun Tsai and Kao-Ching Chen and Chen, {Wei Tseng} and I-Hui Lee and Ru-Band Lu and Po-See Chen and Yen-Kuang Yang",
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T1 - Association between blood level of plasma oxytocin and novelty seeking among methadone-maintained heroin users

AU - Lin, Shih Hsien

AU - Lee, Lan-Ting

AU - Tsai, Hsin-Chun

AU - Chen, Kao-Ching

AU - Chen, Wei Tseng

AU - Lee, I-Hui

AU - Lu, Ru-Band

AU - Chen, Po-See

AU - Yang, Yen-Kuang

PY - 2015/5/6

Y1 - 2015/5/6

N2 - Background: Oxytocin interacts with the dopaminergic system, which plays a role in addiction behaviors. The association between oxytocin and addiction was confirmed in animal studies. Novelty seeking is one of the predictors and indicators of drug addiction. The aim of the present study was to probe the association between oxytocin and novelty seeking. Methods: The study was conducted in a methadone maintenance therapy clinic of a medical center in Taiwan; 77 patients with heroin dependency were enrolled. Plasma oxytocin was measured using an ELISA kit. Novelty seeking was measured using an established instrument (the novelty seeking subscale of the Tridimensional Personality Questionnaire). Results: A significant negative association (ρ = -0.27, p = 0.02; r = -0.34, p = 0.003) between the blood level of plasma oxytocin and novelty seeking was found. This association was significant after controlling the effects of perceived social support and the dosage of methadone (r = -0.32, p = 0.006). Conclusion: The negative association between oxytocin and novelty seeking may provide insight into future treatments for addiction.

AB - Background: Oxytocin interacts with the dopaminergic system, which plays a role in addiction behaviors. The association between oxytocin and addiction was confirmed in animal studies. Novelty seeking is one of the predictors and indicators of drug addiction. The aim of the present study was to probe the association between oxytocin and novelty seeking. Methods: The study was conducted in a methadone maintenance therapy clinic of a medical center in Taiwan; 77 patients with heroin dependency were enrolled. Plasma oxytocin was measured using an ELISA kit. Novelty seeking was measured using an established instrument (the novelty seeking subscale of the Tridimensional Personality Questionnaire). Results: A significant negative association (ρ = -0.27, p = 0.02; r = -0.34, p = 0.003) between the blood level of plasma oxytocin and novelty seeking was found. This association was significant after controlling the effects of perceived social support and the dosage of methadone (r = -0.32, p = 0.006). Conclusion: The negative association between oxytocin and novelty seeking may provide insight into future treatments for addiction.

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