Association between cholesterol plasma levels and craving among heroin users

Shih Hsien Lin, Yen-Kuang Yang, Sheng Yu Lee, Pei-Chun Hsieh, Po-See Chen, Ru-Band Lu, Kao-Ching Chen

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: Lipids may play some roles in the central nervous system functions that are associated with drug addiction. To date, cholesterol is known to influence relapse of cocaine use. However, the relationship between cholesterol and heroin craving is unclear. This study examined the concurrent association between cholesterol and craving. Method: The serum lipid levels of 70 heroin users who were undergoing or had undergone a methadone maintenance therapy were measured. Their craving and demographic data were assessed. Results: Total cholesterol and low-density lipoprotein cholesterol are negatively associated with craving before (r = -0.33, P < 0.01, and r = -0.36, P < 0.01, respectively) and after controlling for the effects of potential confounders (β = -0.38, P < 0.01, and β = -0.42, P < 0.01, respectively). Conclusions: Cholesterol could be associated with the cognitive aspect of craving and may be a potential marker to predict risk of drug relapse.

Original languageEnglish
Pages (from-to)287-291
Number of pages5
JournalJournal of Addiction Medicine
Volume6
Issue number4
DOIs
Publication statusPublished - 2012 Dec 1

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Heroin
Cholesterol
Lipids
Recurrence
Methadone
Cocaine
LDL Cholesterol
Substance-Related Disorders
Cohort Studies
Central Nervous System
Demography
Craving
Serum
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

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title = "Association between cholesterol plasma levels and craving among heroin users",
abstract = "Objective: Lipids may play some roles in the central nervous system functions that are associated with drug addiction. To date, cholesterol is known to influence relapse of cocaine use. However, the relationship between cholesterol and heroin craving is unclear. This study examined the concurrent association between cholesterol and craving. Method: The serum lipid levels of 70 heroin users who were undergoing or had undergone a methadone maintenance therapy were measured. Their craving and demographic data were assessed. Results: Total cholesterol and low-density lipoprotein cholesterol are negatively associated with craving before (r = -0.33, P < 0.01, and r = -0.36, P < 0.01, respectively) and after controlling for the effects of potential confounders (β = -0.38, P < 0.01, and β = -0.42, P < 0.01, respectively). Conclusions: Cholesterol could be associated with the cognitive aspect of craving and may be a potential marker to predict risk of drug relapse.",
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Association between cholesterol plasma levels and craving among heroin users. / Lin, Shih Hsien; Yang, Yen-Kuang; Lee, Sheng Yu; Hsieh, Pei-Chun; Chen, Po-See; Lu, Ru-Band; Chen, Kao-Ching.

In: Journal of Addiction Medicine, Vol. 6, No. 4, 01.12.2012, p. 287-291.

Research output: Contribution to journalArticle

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T1 - Association between cholesterol plasma levels and craving among heroin users

AU - Lin, Shih Hsien

AU - Yang, Yen-Kuang

AU - Lee, Sheng Yu

AU - Hsieh, Pei-Chun

AU - Chen, Po-See

AU - Lu, Ru-Band

AU - Chen, Kao-Ching

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Y1 - 2012/12/1

N2 - Objective: Lipids may play some roles in the central nervous system functions that are associated with drug addiction. To date, cholesterol is known to influence relapse of cocaine use. However, the relationship between cholesterol and heroin craving is unclear. This study examined the concurrent association between cholesterol and craving. Method: The serum lipid levels of 70 heroin users who were undergoing or had undergone a methadone maintenance therapy were measured. Their craving and demographic data were assessed. Results: Total cholesterol and low-density lipoprotein cholesterol are negatively associated with craving before (r = -0.33, P < 0.01, and r = -0.36, P < 0.01, respectively) and after controlling for the effects of potential confounders (β = -0.38, P < 0.01, and β = -0.42, P < 0.01, respectively). Conclusions: Cholesterol could be associated with the cognitive aspect of craving and may be a potential marker to predict risk of drug relapse.

AB - Objective: Lipids may play some roles in the central nervous system functions that are associated with drug addiction. To date, cholesterol is known to influence relapse of cocaine use. However, the relationship between cholesterol and heroin craving is unclear. This study examined the concurrent association between cholesterol and craving. Method: The serum lipid levels of 70 heroin users who were undergoing or had undergone a methadone maintenance therapy were measured. Their craving and demographic data were assessed. Results: Total cholesterol and low-density lipoprotein cholesterol are negatively associated with craving before (r = -0.33, P < 0.01, and r = -0.36, P < 0.01, respectively) and after controlling for the effects of potential confounders (β = -0.38, P < 0.01, and β = -0.42, P < 0.01, respectively). Conclusions: Cholesterol could be associated with the cognitive aspect of craving and may be a potential marker to predict risk of drug relapse.

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