Association between dioxin and diabetes mellitus in an endemic area of exposure in Taiwan a population-based study

Chien Yuan Huang, Cheng Long Wu, Yi-Ching Yang, Jung Wei Chang, Yau-Chang Kuo, Ya Yun Cheng, Jin-Shang Wu, Ching-Chang Lee, How-Ran Guo

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Dioxin has been recognized as an environmental endocrine disruptor, but epidemiology studies of its effects on type 2 diabetes mellitus (DM) found inconsistent results, especially in men. Therefore, we conducted a study in Taiwan to evaluate the association between exposure to dioxin and DM. We recruited participants in an area where the residents were exposed to dioxin released from a factory. Using 20 and 64 pg WHO98-TEQDF/g lipid as the cut-offs, we categorized participants into 3 groups according to the level of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in the serum. We definedDM as a fasting plasma glucose level more than 126 mg/dl or an existing diagnosis. Of the 2898 participants, 425 patients ofDMwere identified, and we observed positive associations between dioxin and DM. After adjusting for age and body mass index (BMI), we found that a high serum dioxin level was an independent risk factor for DM (adjusted odds ratio [AOR] associated with 20-63 pg WHO98-TEQDF/g lipid=2.1, 95% confidence interval [95% CI] 1.5-2.9; AOR for 64 pg WHO98-TEQDF/g lipid=3.2, 95% CI 2.1-4.8). The findings are compatible with those in previous studies of PCDD/Fs. When we stratified the participants by sex, the serum dioxin level remained an independent risk factor for DM in both men and women. Exposure to dioxin is a risk factor for DM, independent of age and BMI in both men and women. Therefore, screening and intervention programs should be considered in endemic areas of exposure to dioxin.

Original languageEnglish
Pages (from-to)e1730
JournalMedicine (United States)
Volume94
Issue number42
DOIs
Publication statusPublished - 2015 Oct 1

Fingerprint

Dioxins
Taiwan
Diabetes Mellitus
Population
Lipids
Body Mass Index
Serum
Odds Ratio
Confidence Intervals
Endocrine Disruptors
Type 2 Diabetes Mellitus
Fasting
Epidemiology
Glucose

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

@article{d291de2f39974571b49280eab3dc4a18,
title = "Association between dioxin and diabetes mellitus in an endemic area of exposure in Taiwan a population-based study",
abstract = "Dioxin has been recognized as an environmental endocrine disruptor, but epidemiology studies of its effects on type 2 diabetes mellitus (DM) found inconsistent results, especially in men. Therefore, we conducted a study in Taiwan to evaluate the association between exposure to dioxin and DM. We recruited participants in an area where the residents were exposed to dioxin released from a factory. Using 20 and 64 pg WHO98-TEQDF/g lipid as the cut-offs, we categorized participants into 3 groups according to the level of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in the serum. We definedDM as a fasting plasma glucose level more than 126 mg/dl or an existing diagnosis. Of the 2898 participants, 425 patients ofDMwere identified, and we observed positive associations between dioxin and DM. After adjusting for age and body mass index (BMI), we found that a high serum dioxin level was an independent risk factor for DM (adjusted odds ratio [AOR] associated with 20-63 pg WHO98-TEQDF/g lipid=2.1, 95{\%} confidence interval [95{\%} CI] 1.5-2.9; AOR for 64 pg WHO98-TEQDF/g lipid=3.2, 95{\%} CI 2.1-4.8). The findings are compatible with those in previous studies of PCDD/Fs. When we stratified the participants by sex, the serum dioxin level remained an independent risk factor for DM in both men and women. Exposure to dioxin is a risk factor for DM, independent of age and BMI in both men and women. Therefore, screening and intervention programs should be considered in endemic areas of exposure to dioxin.",
author = "Huang, {Chien Yuan} and Wu, {Cheng Long} and Yi-Ching Yang and Chang, {Jung Wei} and Yau-Chang Kuo and Cheng, {Ya Yun} and Jin-Shang Wu and Ching-Chang Lee and How-Ran Guo",
year = "2015",
month = "10",
day = "1",
doi = "10.1097/MD.0000000000001730",
language = "English",
volume = "94",
pages = "e1730",
journal = "Medicine (United States)",
issn = "0025-7974",
publisher = "Lippincott Williams and Wilkins",
number = "42",

}

Association between dioxin and diabetes mellitus in an endemic area of exposure in Taiwan a population-based study. / Huang, Chien Yuan; Wu, Cheng Long; Yang, Yi-Ching; Chang, Jung Wei; Kuo, Yau-Chang; Cheng, Ya Yun; Wu, Jin-Shang; Lee, Ching-Chang; Guo, How-Ran.

In: Medicine (United States), Vol. 94, No. 42, 01.10.2015, p. e1730.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association between dioxin and diabetes mellitus in an endemic area of exposure in Taiwan a population-based study

AU - Huang, Chien Yuan

AU - Wu, Cheng Long

AU - Yang, Yi-Ching

AU - Chang, Jung Wei

AU - Kuo, Yau-Chang

AU - Cheng, Ya Yun

AU - Wu, Jin-Shang

AU - Lee, Ching-Chang

AU - Guo, How-Ran

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Dioxin has been recognized as an environmental endocrine disruptor, but epidemiology studies of its effects on type 2 diabetes mellitus (DM) found inconsistent results, especially in men. Therefore, we conducted a study in Taiwan to evaluate the association between exposure to dioxin and DM. We recruited participants in an area where the residents were exposed to dioxin released from a factory. Using 20 and 64 pg WHO98-TEQDF/g lipid as the cut-offs, we categorized participants into 3 groups according to the level of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in the serum. We definedDM as a fasting plasma glucose level more than 126 mg/dl or an existing diagnosis. Of the 2898 participants, 425 patients ofDMwere identified, and we observed positive associations between dioxin and DM. After adjusting for age and body mass index (BMI), we found that a high serum dioxin level was an independent risk factor for DM (adjusted odds ratio [AOR] associated with 20-63 pg WHO98-TEQDF/g lipid=2.1, 95% confidence interval [95% CI] 1.5-2.9; AOR for 64 pg WHO98-TEQDF/g lipid=3.2, 95% CI 2.1-4.8). The findings are compatible with those in previous studies of PCDD/Fs. When we stratified the participants by sex, the serum dioxin level remained an independent risk factor for DM in both men and women. Exposure to dioxin is a risk factor for DM, independent of age and BMI in both men and women. Therefore, screening and intervention programs should be considered in endemic areas of exposure to dioxin.

AB - Dioxin has been recognized as an environmental endocrine disruptor, but epidemiology studies of its effects on type 2 diabetes mellitus (DM) found inconsistent results, especially in men. Therefore, we conducted a study in Taiwan to evaluate the association between exposure to dioxin and DM. We recruited participants in an area where the residents were exposed to dioxin released from a factory. Using 20 and 64 pg WHO98-TEQDF/g lipid as the cut-offs, we categorized participants into 3 groups according to the level of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in the serum. We definedDM as a fasting plasma glucose level more than 126 mg/dl or an existing diagnosis. Of the 2898 participants, 425 patients ofDMwere identified, and we observed positive associations between dioxin and DM. After adjusting for age and body mass index (BMI), we found that a high serum dioxin level was an independent risk factor for DM (adjusted odds ratio [AOR] associated with 20-63 pg WHO98-TEQDF/g lipid=2.1, 95% confidence interval [95% CI] 1.5-2.9; AOR for 64 pg WHO98-TEQDF/g lipid=3.2, 95% CI 2.1-4.8). The findings are compatible with those in previous studies of PCDD/Fs. When we stratified the participants by sex, the serum dioxin level remained an independent risk factor for DM in both men and women. Exposure to dioxin is a risk factor for DM, independent of age and BMI in both men and women. Therefore, screening and intervention programs should be considered in endemic areas of exposure to dioxin.

UR - http://www.scopus.com/inward/record.url?scp=84947902121&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84947902121&partnerID=8YFLogxK

U2 - 10.1097/MD.0000000000001730

DO - 10.1097/MD.0000000000001730

M3 - Article

C2 - 26496286

AN - SCOPUS:84947902121

VL - 94

SP - e1730

JO - Medicine (United States)

JF - Medicine (United States)

SN - 0025-7974

IS - 42

ER -