TY - JOUR
T1 - Association between dioxin and diabetes mellitus in an endemic area of exposure in Taiwan a population-based study
AU - Huang, Chien Yuan
AU - Wu, Cheng Long
AU - Yang, Yi Ching
AU - Chang, Jung Wei
AU - Kuo, Yau Chang
AU - Cheng, Ya Yun
AU - Wu, Jin Shang
AU - Lee, Ching Chang
AU - Guo, How Ran
N1 - Publisher Copyright:
© 2015 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Dioxin has been recognized as an environmental endocrine disruptor, but epidemiology studies of its effects on type 2 diabetes mellitus (DM) found inconsistent results, especially in men. Therefore, we conducted a study in Taiwan to evaluate the association between exposure to dioxin and DM. We recruited participants in an area where the residents were exposed to dioxin released from a factory. Using 20 and 64 pg WHO98-TEQDF/g lipid as the cut-offs, we categorized participants into 3 groups according to the level of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in the serum. We definedDM as a fasting plasma glucose level more than 126 mg/dl or an existing diagnosis. Of the 2898 participants, 425 patients ofDMwere identified, and we observed positive associations between dioxin and DM. After adjusting for age and body mass index (BMI), we found that a high serum dioxin level was an independent risk factor for DM (adjusted odds ratio [AOR] associated with 20-63 pg WHO98-TEQDF/g lipid=2.1, 95% confidence interval [95% CI] 1.5-2.9; AOR for 64 pg WHO98-TEQDF/g lipid=3.2, 95% CI 2.1-4.8). The findings are compatible with those in previous studies of PCDD/Fs. When we stratified the participants by sex, the serum dioxin level remained an independent risk factor for DM in both men and women. Exposure to dioxin is a risk factor for DM, independent of age and BMI in both men and women. Therefore, screening and intervention programs should be considered in endemic areas of exposure to dioxin.
AB - Dioxin has been recognized as an environmental endocrine disruptor, but epidemiology studies of its effects on type 2 diabetes mellitus (DM) found inconsistent results, especially in men. Therefore, we conducted a study in Taiwan to evaluate the association between exposure to dioxin and DM. We recruited participants in an area where the residents were exposed to dioxin released from a factory. Using 20 and 64 pg WHO98-TEQDF/g lipid as the cut-offs, we categorized participants into 3 groups according to the level of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in the serum. We definedDM as a fasting plasma glucose level more than 126 mg/dl or an existing diagnosis. Of the 2898 participants, 425 patients ofDMwere identified, and we observed positive associations between dioxin and DM. After adjusting for age and body mass index (BMI), we found that a high serum dioxin level was an independent risk factor for DM (adjusted odds ratio [AOR] associated with 20-63 pg WHO98-TEQDF/g lipid=2.1, 95% confidence interval [95% CI] 1.5-2.9; AOR for 64 pg WHO98-TEQDF/g lipid=3.2, 95% CI 2.1-4.8). The findings are compatible with those in previous studies of PCDD/Fs. When we stratified the participants by sex, the serum dioxin level remained an independent risk factor for DM in both men and women. Exposure to dioxin is a risk factor for DM, independent of age and BMI in both men and women. Therefore, screening and intervention programs should be considered in endemic areas of exposure to dioxin.
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U2 - 10.1097/MD.0000000000001730
DO - 10.1097/MD.0000000000001730
M3 - Article
C2 - 26496286
AN - SCOPUS:84947902121
SN - 0025-7974
VL - 94
SP - e1730
JO - Medicine (United States)
JF - Medicine (United States)
IS - 42
ER -