Association between serotonin transporter availability and overall rating scores of quality of life in healthy volunteers

Hsin Chun Tsai, Tzung Lieh Yeh, Ming Hong Hsieh, I. Hui Lee, Kao Ching Chen, Po See Chen, Yen Kuang Yang, Wei Jen Yao

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Depression and impaired quality of life (QOL) are frequently observed in patients suffering from a variety of diseases. In addition, it has been reported that an enhanced degradation of the serotonin precursor tryptophan may contribute to QOL deterioration in some diseases. However, it is unclear whether the correlation between the QOL scores and the central serotonergic tone is only mediated by the severity of either the depression symptoms or the physical illness itself. The present study examined the relationship between serotonin transporter (SERT) availability and life quality as measured by the World Health Organization Quality of Life brief version questionnaire (WHO-QOL) in healthy participants in order to exclude the influence of depressive mood and disease. The SERT availability in the midbrain was approximated using SPECT with [123I] ADAM ligand in fifty-eight healthy volunteers. The overall rating sub scores of the WHO-QOL correlated positively with serotonin transporter availability in the males. Central serotoninergic activity may play a role in the overall rating scores of the WHO-QOL.

Original languageEnglish
Pages (from-to)711-714
Number of pages4
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume33
Issue number4
DOIs
Publication statusPublished - 2009 Jun 15

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Biological Psychiatry

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