Association between somatization subscale score and serotonin transporter availability in healthy volunteers-a single photon emission computed tomography study with [ 123I] ADAM

Ming Hui Chou, Kao Chin Chen, Tzung Lieh Yeh, I. Hui Lee, Wei Jen Yao, Po See Chen, Kang Wei Chang, Mei Hsiu Liao, Yen Kuang Yang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Rationale and objective: Serotonin is one of the key neuromodulators involved in fundamental cerebral functions and behaviors. Previous study has demonstrated that somatization symptoms are probably associated with central serotonergic circuits, which are implicated in anxiety and nociception regulation. This study aims to examine the correlation between somatization subscale score and serotonin transporter (SERT) availability in healthy volunteers. Methods: Sixty-four healthy participants, 26 males and 38 females, were enrolled from the community and were administered the single somatization subscale of the Chinese symptom checklist 90 revised (SCL90-R). Single photon emission computed tomography with [ 123I] 2-((2-((dimethylamino) methyl)phenyl)thio)-5-iodophenylamine was also performed to examine SERT availability. Results: The somatization scores were negatively correlated with SERT availability (Spearman's ρ∈=∈-0.35, p∈=∈0.005), particularly in males (Spearman's ρ∈=∈-0.54, p∈=∈0.004). Conclusion: This result reconfirmed the correlation between central serotonergic activity and the intensity of somatization symptoms, even in healthy participants. However, a gender difference exists in this correlation.

Original languageEnglish
Pages (from-to)1011-1016
Number of pages6
JournalPsychopharmacology
Volume219
Issue number4
DOIs
Publication statusPublished - 2012 Feb 1

All Science Journal Classification (ASJC) codes

  • Pharmacology

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