Association between the dexamethasone suppression test and serotonin transporter availability in healthy volunteers - A SPECT with [123I] ADAM study

Hsiang Yi Tsai, I. Hui Lee, Tzung Lieh Yeh, Wei Jen Yao, Kao Chin Chen, Po See Chen, Nan Tsing Chiu, Ru Band Lu, Yen Kuang Yang

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Most common psychiatric diseases have been found to be associated with disturbance of both the hypothalamic-pituitary-adrenal (HPA) axis and the brain serotonergic system. The aim of this study was to explore the neuroendocrine relationships between the dexamethasone suppression test (DST) and serotonin transporter (SERT) availability in healthy volunteers. Sixty-six participants (30 males and 36 females) were recruited from the community. The DST suppression rate (D%) is the reduction in cortisol level from Day 1 (D1) to Day 2 (D2) in proportion to the Day 1 cortisol level (D%=(D1-D2)/D1×100%). SPECT with [123I] ADAM was used to measure SERT availability. A significant correlation between D% and SERT availability was noted in all subjects (Spearman's ρ=0.26, p=0.03) and in the male subjects (Spearman's ρ=0.41, p=0.02). SERT availability may be sensitive to changes in DST, especially in males.

Original languageEnglish
Pages (from-to)641-646
Number of pages6
JournalEuropean Neuropsychopharmacology
Volume22
Issue number9
DOIs
Publication statusPublished - 2012 Sep 1

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Pharmacology (medical)

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