TY - JOUR
T1 - Association of central aortic pressures indexes with development of diabetes mellitus in essential hypertension
AU - Chen, Ju Yi
AU - Chou, Chang Hua
AU - Lee, Yungling Leo
AU - Tsai, Wei Chuan
AU - Lin, Chih Chan
AU - Huang, Yao Yi
AU - Chen, Jyh Hong
N1 - Funding Information:
Acknowledgments: This study was supported by grant NSC 97-2314-B-006-054 from the National Science Council, Executive Yuan, Taipei, Taiwan.
PY - 2010/10/27
Y1 - 2010/10/27
N2 - Background: Diabetes mellitus (DM) and hypertension (HT) frequently coexist. Increased central aortic pressures indexes are associated with HT; however, possible associations of these indexes with future development of DM have never been studied in HT.MethodsWe recruited 178 patients with uncomplicated nondiabetic HT in this study. Baseline glucose, insulin, lipid profiles, and central aortic pressure indexes obtained using applanation tonometry were measured at the beginning of the study. Patients were followed for new-onset DM.ResultsAfter a mean follow-up period of 31 12 months, 22 patients (12.4%) developed new-onset DM. In multivariate regression analyses adjusted for age, sex, and mean blood pressure (BP) in model 1, we found that central systolic BP (CSBP; hazard ratio 1.24, 95% CI 1.10-1.41, P 0.001), and augmentation index (AIx) corrected at heart rate 75/min (AIx 75; hazard ratio 1.58, 95% CI 1.11-1.58, P 0.05) were independent predictors for new-onset DM. After adjustment for age, sex, mean BP, glucose concentration, and Β-blocker use in model 2, we found that CSBP (hazard ratio 1.36, 95% CI 1.19-1.55, P 0.001) and AIx 75 (hazard ratio 1.71, 95% CI 1.16-2.52, P 0.01) were independent predictors for new-onset DM.ConclusionsCSBP and AIx 75 were independent factors for future DM in essential hypertensive patients. Increased central pressure indexes were associated with risk of DM in essential hypertension.
AB - Background: Diabetes mellitus (DM) and hypertension (HT) frequently coexist. Increased central aortic pressures indexes are associated with HT; however, possible associations of these indexes with future development of DM have never been studied in HT.MethodsWe recruited 178 patients with uncomplicated nondiabetic HT in this study. Baseline glucose, insulin, lipid profiles, and central aortic pressure indexes obtained using applanation tonometry were measured at the beginning of the study. Patients were followed for new-onset DM.ResultsAfter a mean follow-up period of 31 12 months, 22 patients (12.4%) developed new-onset DM. In multivariate regression analyses adjusted for age, sex, and mean blood pressure (BP) in model 1, we found that central systolic BP (CSBP; hazard ratio 1.24, 95% CI 1.10-1.41, P 0.001), and augmentation index (AIx) corrected at heart rate 75/min (AIx 75; hazard ratio 1.58, 95% CI 1.11-1.58, P 0.05) were independent predictors for new-onset DM. After adjustment for age, sex, mean BP, glucose concentration, and Β-blocker use in model 2, we found that CSBP (hazard ratio 1.36, 95% CI 1.19-1.55, P 0.001) and AIx 75 (hazard ratio 1.71, 95% CI 1.16-2.52, P 0.01) were independent predictors for new-onset DM.ConclusionsCSBP and AIx 75 were independent factors for future DM in essential hypertensive patients. Increased central pressure indexes were associated with risk of DM in essential hypertension.
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U2 - 10.1038/ajh.2010.145
DO - 10.1038/ajh.2010.145
M3 - Article
C2 - 20634800
AN - SCOPUS:77956829635
SN - 0895-7061
VL - 23
SP - 1069
EP - 1073
JO - American Journal of Hypertension
JF - American Journal of Hypertension
IS - 10
ER -