Association of central aortic pressures indexes with development of diabetes mellitus in essential hypertension

Ju Yi Chen, Chang Hua Chou, Yungling Leo Lee, Wei Chuan Tsai, Chih Chan Lin, Yao Yi Huang, Jyh Hong Chen

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Background: Diabetes mellitus (DM) and hypertension (HT) frequently coexist. Increased central aortic pressures indexes are associated with HT; however, possible associations of these indexes with future development of DM have never been studied in HT.MethodsWe recruited 178 patients with uncomplicated nondiabetic HT in this study. Baseline glucose, insulin, lipid profiles, and central aortic pressure indexes obtained using applanation tonometry were measured at the beginning of the study. Patients were followed for new-onset DM.ResultsAfter a mean follow-up period of 31 12 months, 22 patients (12.4%) developed new-onset DM. In multivariate regression analyses adjusted for age, sex, and mean blood pressure (BP) in model 1, we found that central systolic BP (CSBP; hazard ratio 1.24, 95% CI 1.10-1.41, P 0.001), and augmentation index (AIx) corrected at heart rate 75/min (AIx 75; hazard ratio 1.58, 95% CI 1.11-1.58, P 0.05) were independent predictors for new-onset DM. After adjustment for age, sex, mean BP, glucose concentration, and Β-blocker use in model 2, we found that CSBP (hazard ratio 1.36, 95% CI 1.19-1.55, P 0.001) and AIx 75 (hazard ratio 1.71, 95% CI 1.16-2.52, P 0.01) were independent predictors for new-onset DM.ConclusionsCSBP and AIx 75 were independent factors for future DM in essential hypertensive patients. Increased central pressure indexes were associated with risk of DM in essential hypertension.

Original languageEnglish
Pages (from-to)1069-1073
Number of pages5
JournalAmerican Journal of Hypertension
Issue number10
Publication statusPublished - 2010 Oct 27

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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